{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T04:24:02Z","timestamp":1765081442895,"version":"3.46.0"},"reference-count":27,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1965,9]]},"abstract":"<jats:p>Platelet fibrinogen has been studied in normal, thrombasthenic, and hypofibrinogenaemic subjects. It has been differentiated into adsorbed (plasma) and extractable (intraplatelet) fractions. Isotopic studies suggest that exchange does not occur between intraplatelet and plasma fibrinogen and it appears possible that the intra-platelet fraction may be derived from the megakaryocyte. Six of nine thrombasthenic patients were found to have a severe deficiency of both adsorbed and extractable fibrinogen. Since the remaining three had near-normal platelet fibrinogen and all nine failed to aggregate it is improbable that the failure to adsorb fibrinogen is responsible for the defect in aggregation. Magnesium partially corrects adhesion to fibrin and clot retraction by these platelets, but has not been found to influence their fibrinogen adsorption. It is considered that the basic platelet surface defect, of varying severity, is responsible for the abnormalities of adsorption, aggregation, and adhesion in thrombasthenia. In the case of congenital hypofibrinogenaemia, fibrinogen transfusion corrects the long bleeding time, platelet-adsorbed fibrinogen, and the ability of platelets to spread on glass. It is possible that fibrinogen influences the surface properties of human platelets, although the final mechanism is not determined.<\/jats:p>","DOI":"10.1136\/jcp.18.5.579","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"579-585","source":"Crossref","is-referenced-by-count":56,"title":["Platelet fibrinogen"],"prefix":"10.1136","volume":"18","author":[{"given":"P. A.","family":"Castaldi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Caen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1965,9,1]]},"reference":[{"key":"ref_1","first-page":"843","article-title":"Congenital afibrinogenaemia (a study of some basic aspects of coagulation)","volume":"9","author":"Alexander, B.; Goldstein, R.; Rich, L.; Le Bolloc'h, A.G.; K., Diamond L.; Borges, W.","year":"1954","unstructured":"Alexander, B., Goldstein, R., Rich, L., Le Bolloc'h, A. G., Diamond L. K., and Borges, W. (1954). Congenital afibrinogenaemia (a study of some basic aspects of coagulation). 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In preparation."},{"key":"ref_4","first-page":"321","article-title":"Necrose isch6mique bilaterale dans un cas de grande hypofibrinogen6mie cong6nitale","volume":"4","author":"Faur, Y.; Inceman, S.; Chassigneux, J.; Seligmann, M.; Anagnostopoulos, T.; Bernard, J.","year":"1964","unstructured":"Faur, Y., Inceman, S., Chassigneux, J., Seligmann, M., Anagnostopoulos, T., and Bernard, J. (1964). Necrose isch6mique bilaterale dans un cas de grande hypofibrinogen6mie cong6nitale. Nouv. Rev. franc. Hemat., 4, 321.","journal-title":"Nouv. Rev. franc. Hemat"},{"key":"ref_5","first-page":"614","article-title":"Considerations sur l'allongement du temps de saignement dans l'afibrinog6nemie cong6nitale","volume":"3","author":"Faur, Y.; Inceman, S.; Chassigneux, J.; Seligmann, M.; Anagnostopoulos, T.; Bernard, J.; Inceman, S.","year":"1963","unstructured":"Faur, Y., Inceman, S., Chassigneux, J., Seligmann, M., Anagnostopoulos, T., and Bernard, J. and Inceman, S. (1963). Considerations sur l'allongement du temps de saignement dans l'afibrinog6nemie cong6nitale. Ibid., 3, 614.","journal-title":"Ibid"},{"key":"ref_6","first-page":"251","article-title":"Etude microscopique du caillot normal et pathologique (Les thrombasth6nies constitutionelles et exp6rimentales). Effet du magnesium et de 1'ATP","volume":"3","author":"Lasneret, J.; Michel, H.","year":"1963","unstructured":"Lasneret, J., and Michel, H. (1963). Etude microscopique du caillot normal et pathologique (Les thrombasth6nies constitutionelles et exp6rimentales). Effet du magnesium et de 1'ATP. Ibid., 3, 251.","journal-title":"Ibid"},{"key":"ref_7","article-title":"Fibrinogen of thrombasthenic platelets. 10th Congr","volume":"8","author":"Castaldi, P.; Caen, J.; Seligmann, M.; Lasneret, J.","year":"1964","unstructured":"Castaldi, P., Caen, J., Seligmann, M., and Lasneret, J. (1964). Fibrinogen of thrombasthenic platelets. 10th Congr. int.Soc. Haematol., Stockholm. K.8.","journal-title":"Soc. Haematol., Stockholm"},{"key":"ref_8","first-page":"13","article-title":"The role of the connective tissues in arterial diseases","volume-title":"Connective Tissue, Thrombosis and Atherosclerosis","author":"Duguid, J.B.","year":"1959","unstructured":"Duguid, J. B. (1959). The role of the connective tissues in arterial diseases. In Connective Tissue, Thrombosis and Atherosclerosis, p. 13., edited by I. H. Page. Academic Press, New York and London."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1136\/bmj.1.4549.493","volume":"1","author":"Elek, F.D.","year":"1948","unstructured":"Elek, F. D. (1948). Brit. Med. J., 1, 493.","journal-title":"Brit. Med. 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Num6ration des plaquettes sanguines utilisant un liquide hypotonique a base de chlorhydrate de procaine. Sang, 30, 144.","journal-title":"Sang"},{"key":"ref_19","article-title":"Some observations on the blood-clotting mechanism. The role of fibrinogen and platelets, with reference to a case of congenital afibrinogenaemia","author":"Pinniger, J.L.; Prunty, F.T.G.","year":"1946","unstructured":"Pinniger, J. L., and Prunty, F. T. G. (1946). Some observations on the blood-clotting mechanism. The role of fibrinogen and platelets, with reference to a case of congenital afibrinogenaemia. Brit. J."},{"key":"ref_20","article-title":"Transfusion (Paris), in the press","author":"Reuge, C.","year":"1965","unstructured":"Reuge, C. (1965). Transfusion (Paris), in the press."},{"key":"ref_21","article-title":"Blood coagulation as a continuous process","volume-title":"Thrombos.","author":"Roos, J.","year":"1957","unstructured":"Roos, J. (1957). Blood coagulation as a continuous process. 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Invest"},{"key":"ref_24","first-page":"302","article-title":"Etudes immunochimiques sur la pr6sence du fibrinogene dans des extraits de plaquettes humaines lav6es et dans certains extraits leucocytaires","volume":"12","author":"Seligmann, M.; Goudemand, M.; Janin, A.; Bernard, J.; Grabar, P.","year":"1957","unstructured":"Seligmann, M., Goudemand, M., Janin, A., Bernard, J., and Grabar, P. (1957). Etudes immunochimiques sur la pr6sence du fibrinogene dans des extraits de plaquettes humaines lav6es et dans certains extraits leucocytaires. Rev. Hemat., 12, 302.","journal-title":"Rev. Hemat"},{"key":"ref_25","article-title":"Etude morphologique des plaquettes sanguines et de la m6tamorphose visqueuse au moyen d'anti-serums fluorescents antifibrinogene et antiplaquettes","author":"Sokal, G.","year":"1962","unstructured":"Sokal, G. (1962). Etude morphologique des plaquettes sanguines et de la m6tamorphose visqueuse au moyen d'anti-serums fluorescents antifibrinogene et antiplaquettes. 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(Stuttg.), suppl., 13, p. 301.","journal-title":"(Stuttg.), suppl"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.18.5.579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:51:32Z","timestamp":1765075892000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.18.5.579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1965,9]]},"references-count":27,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1965,9,1]]},"published-print":{"date-parts":[[1965,9]]}},"alternative-id":["10.1136\/jcp.18.5.579"],"URL":"https:\/\/doi.org\/10.1136\/jcp.18.5.579","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1965,9]]}}}