{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:10:57Z","timestamp":1761487857892,"version":"3.44.0"},"reference-count":35,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1966,3]]},"abstract":"<jats:p>A comparison was made between the effects of atheromatous and normal areas of the same aorta on coagulation, fibrinolytic, and platelet aggregating systems.<\/jats:p>\n               <jats:p>In the thromboplastin generation test it was found that atheromatous aorta possessed significantly greater ability to generate intrinsic prothrombin activator than did normal aortic tissue. But, by the one-stage prothrombin time technique, the content of extrinsic thromboplastin in both types of aorta was similar.<\/jats:p>\n               <jats:p>Aortic preparations, consisting of intimal and medial layers only, were not found to possess fibrinolytic ability and did not contain inhibitors of the fibrinolytic system.<\/jats:p>\n               <jats:p>The adhesion of platelets to ulcerated atheromatous areas of aorta was significantly greater than to normal or non-ulcerated atheromatous areas. However, homogenates of atheromatous and normal aorta did not differ in their ability to accelerate platelet aggregation and fibrin clot formation when tested by a modified Chandler's tube technique.<\/jats:p>\n               <jats:p>The significance of the findings is discussed and the suggestion made that the mechanisms by which atheromatous aortic tissue might predispose towards intravascular thrombosis <jats:italic>in vivo<\/jats:italic> are the ability of such tissue to enhance intrinsic prothrombin activator formation and platelet aggregation.<\/jats:p>","DOI":"10.1136\/jcp.19.2.154","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"154-158","source":"Crossref","is-referenced-by-count":24,"title":["Effects on blood coagulation, fibrinolysis, and platelet aggregation of normal and atheromatous aortic tissue"],"prefix":"10.1136","volume":"19","author":[{"given":"C. R. 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