{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:45:41Z","timestamp":1765701941990,"version":"3.48.0"},"reference-count":24,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1967,1]]},"abstract":"<jats:p>\n                    Cervical biopsies from 97 women with malignant cells in cervical scrape smears have been studied. Forty-eight patients had invasive squamous carcinoma, and 49 had intraepithelial lesions. Of these, six had dedifferentiated carcinoma\n                    <jats:italic>in situ<\/jats:italic>\n                    , nine had the differentiated lesions generally known as `severe dysplasia', and 29 had both; the severity of the dysplasia remained doubtful in five patients.\n                  <\/jats:p>\n                  <jats:p>The `severe dysplasia' was compared with invasive carcinoma. A cellular analysis of the biopsies showed that the two categories have a number of features in common, chiefly the presence of atypical and normal mitoses, nucleoli, horn cells, and giant cells. The stratification of the epithelium in `severe dysplasia' is invariably abnormal and the architecture closely resembles that of invasive carcinoma. The cells in the smears from `severe dysplasia' are similar to those in invasive carcinoma.<\/jats:p>\n                  <jats:p>\n                    It is suggested on the basis of these observations that a `severe dysplasia' should be interpreted as a differentiated carcinoma\n                    <jats:italic>in situ<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1136\/jcp.20.1.7","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"7-14","source":"Crossref","is-referenced-by-count":7,"title":["Squamous differentiation in carcinoma\n                    <i>in situ<\/i>\n                    of the cervix uteri"],"prefix":"10.1136","volume":"20","author":[{"given":"Chandra","family":"Grubb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Janota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1967,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0002-9378(65)90657-5","volume":"93","author":"de Brux, J.; Dupre-Froment, J.","year":"1965","unstructured":"de Brux, J., and Dupre-Froment, J. (1965). Amer. J. Obstet. Gynec., 93, 181.","journal-title":"Amer. J. Obstet. Gynec"},{"key":"ref_2","first-page":"807","volume":"64","author":"Ewing, J.quoted by Hertig; T., A.; Young, P.","year":"1952","unstructured":"Ewing, J. quoted by Hertig, A. T., and Young, P. (1952). Ibid., 64, 807.","journal-title":"Ibid"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/1097-0142(195603\/04)9:2<374::AID-CNCR2820090224>3.0.CO;2-P","volume":"9","author":"Fennel, R.H.","year":"1956","unstructured":"Fennel, R. H. (1956). Cancer (Philad.), 9, 374.","journal-title":"Cancer (Philad.)"},{"key":"ref_4","article-title":"The Cervix Uteri and its Diseases","author":"Fluhmann, C.F.","year":"1961","unstructured":"Fluhmann, C. F. (1961). The Cervix Uteri and its Diseases. Saunders, Philadelphia and London."},{"key":"ref_5","article-title":"The Cytological Diagnosis of Cancer","author":"Graham, R.M.","year":"1963","unstructured":"Graham, R. M. (1963). The Cytological Diagnosis of Cancer. Saunders, Philadelphia and London.","journal-title":"Saunders, Philadelphia and London"},{"key":"ref_6","article-title":"Gynaecological Pathology","author":"Haines, M.; Taylor, C.W.","year":"1962","unstructured":"Haines, M., and Taylor, C. W. (1962). Gynaecological Pathology."},{"key":"ref_7","series-title":"Proceedings of the First International Congress of Exfoliative Cytology, Vienna. Lippincott, Philadelphia and Montreal","article-title":"International Committee on Histological Terminology for Lesions of the Uterine Cervix","author":"Churchill, London","year":"1962","unstructured":"Churchill, London. International Committee on Histological Terminology for Lesions of the Uterine Cervix (Co-chairmen: H. Bettinger and J. W. Reagan). (1962). In Proceedings of the First International Congress of Exfoliative Cytology, Vienna. Lippincott, Philadelphia and Montreal."},{"key":"ref_8","first-page":"80","volume":"10","author":"Kirkland, J.A.","year":"1966","unstructured":"Kirkland, J. A. (1966). Acta cytol. (Philad.), 10, 80.","journal-title":"Acta cytol. (Philad.)"},{"key":"ref_9","article-title":"Diagnostic Cytology and its Histopathologic Basis","author":"Koss, L.G.; Durfee, G.R.","year":"1961","unstructured":"Koss, L. G., and Durfee, G. R. (1961). Diagnostic Cytology and its Histopathologic Basis. Pitman, London."},{"key":"ref_10","first-page":"14","volume":"73","author":"Meyer, R.","year":"1941","unstructured":"Meyer, R. (1941a). Surg. Gynec. Obstet., 73, 14.","journal-title":"Surg. Gynec. Obstet"},{"key":"ref_11","first-page":"129","volume":"73","author":"Meyer, R.","year":"1941","unstructured":"Meyer, R. (1941b). Ibid., 73, 129.","journal-title":"Ibid"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1002\/1097-0142(196512)18:12<1622::AID-CNCR2820181214>3.0.CO;2-3","volume":"18","author":"Old, J.W.; Jones, D.G.","year":"1965","unstructured":"Old, J. W., and Jones, D. G. (1965). Cancer (Philad.), 18, 1622.","journal-title":"Cancer (Philad.)"},{"key":"ref_13","first-page":"1598","volume":"18","author":"Old, J.W.; Jones, D.G.; Wielenga, G.; von Haam, E.","year":"1965","unstructured":"Old, J. W., and Jones, D. G., Wielenga, G., and von Haam, E. (1965). Ibid., 18, 1598.","journal-title":"Ibid"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/0002-9378(57)90057-1","volume":"74","author":"Peckham, B.; Green, R.R.","year":"1957","unstructured":"Peckham, B., and Green, R. R. (1957). Amer. J. Obstet. Gynec., 74, 804, and Discussion, p. 812.","journal-title":"Amer. J. Obstet. Gynec; and Discussion"},{"key":"ref_15","article-title":"Precancerous changes of the cervical epithelium in relation to manifest cervical carcinoma. Acta radiol","author":"Petersen, 0","year":"1955","unstructured":"Petersen, 0. (1955). Precancerous changes of the cervical epithelium in relation to manifest cervical carcinoma. Acta radiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/1097-0142(195603\/04)9:2<385::AID-CNCR2820090225>3.0.CO;2-I","volume":"9","author":"Reagen, J.W.; Hamonic, M.","year":"1956","unstructured":"Reagen, J. W., and Hamonic, M. (1956). Cancer (Philad.), 9, 385.","journal-title":"Cancer (Philad.)"},{"key":"ref_17","first-page":"1200","volume":"6","author":"Reagen, J.W.; Hamonic, M.; Hicks, D.J.","year":"1953","unstructured":"Reagen, J. W., and Hamonic, M. and Hicks, D. J. (1953). Ibid., 6, 1200.","journal-title":"Ibid"},{"key":"ref_18","first-page":"105","volume":"28","author":"Reagen, J.W.; Hamonic, M.; Hicks, D.J.; Moore, R.D.","year":"1952","unstructured":"Reagen, J. W., and Hamonic, M. and Hicks, D. J. and Moore, R. D. (1952). Amer. J. Path., 28, 105.","journal-title":"Amer. J. Path"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/1097-0142(195303)6:2<224::AID-CNCR2820060203>3.0.CO;2-H","volume":"6","author":"Seidemann, I.L.; Saracusa, Y.","year":"1953","unstructured":"Seidemann, I. L., and Saracusa, Y. (1953). Cancer (Philad.), 6, 224.","journal-title":"Cancer (Philad.)"},{"key":"ref_20","first-page":"668","volume":"62","author":"Rubin, I.C.","year":"1910","unstructured":"Rubin, I. C. (1910). Amer. J. Obstet. 62, 668.","journal-title":"Amer. J. Obstet"},{"key":"ref_21","first-page":"210","volume":"56","author":"Schiller, W.","year":"1933","unstructured":"Schiller, W. (1933). Surg. Gynec. Obstet., 56, 210.","journal-title":"Surg. Gynec. Obstet"},{"key":"ref_22","first-page":"1383","volume":"1","author":"Spriggs, A.I.; Boddington, M.M.; Clarke, C.M.","year":"1962","unstructured":"Spriggs, A. I., Boddington, M. M., and Clarke, C. M. (1962). Lancet, 1, 1383.","journal-title":"Lancet"},{"key":"ref_23","article-title":"Exfoliativ, e Cytology in Gynaecological Practice","author":"Wachtel, E.","year":"1964","unstructured":"Wachtel, E. (1964). Exfoliativ,e Cytology in Gynaecological Practice. Butterworths, London."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/1097-0142(196509)18:9<1101::AID-CNCR2820180910>3.0.CO;2-U","volume":"18","author":"Wakonig-Vaartaja, R.; Kirkland, J.A.","year":"1965","unstructured":"Wakonig-Vaartaja, R., and Kirkland, J. A. (1965). Cancer (Philad.), 18, 1101.","journal-title":"Cancer (Philad.)"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.20.1.7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:44:30Z","timestamp":1765701870000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.20.1.7"}},"subtitle":["A cyto-histological correlation of malignant intraepithelial lesions with invasive carcinoma"],"short-title":[],"issued":{"date-parts":[[1967,1]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1967,1,1]]},"published-print":{"date-parts":[[1967,1]]}},"alternative-id":["10.1136\/jcp.20.1.7"],"URL":"https:\/\/doi.org\/10.1136\/jcp.20.1.7","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1967,1]]}}}