{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:10:11Z","timestamp":1758845411282,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1967,3]]},"abstract":"<jats:p>Thirty-one subjects from three families affected by Von Willebrand's disease have been investigated with the following tests: Ivy's bleeding time; platelet adhesiveness according to Salzman; two-stage factor VIII assay. Twelve patients have a complete form of the disease, <jats:italic>i.e.<\/jats:italic>, a prolonged bleeding time with low platelet adhesiveness, and a reduced factor VIII level. Eight subjects have an isolated low platelet adhesiveness associated in three cases with a prolonged bleeding time. The low platelet adhesiveness in these subjects was corrected, as in Von Willebrand's disease, by infusion of haemophilia A plasma. The dominant autosomal mode of inheritance appears to be due to a pleiotropic gene, expressed in a variety of ways<\/jats:p>","DOI":"10.1136\/jcp.20.2.190","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"190-194","source":"Crossref","is-referenced-by-count":17,"title":["Biological findings in Von Willebrand's pedigrees: implications for inheritance"],"prefix":"10.1136","volume":"20","author":[{"given":"Dominique","family":"Meyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Jos\u00e9","family":"Larrieu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Maroteaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques P.","family":"Caen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1967,3,1]]},"reference":[{"key":"ref_1","first-page":"203","volume":"4","author":"Barrow, E.M.; Graham, J.B.","year":"1964","unstructured":"Barrow, E. M., and Graham, J. B. (1964). Progr. Hemat., 4, 203","journal-title":"Progr. Hemat"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1365-2141.1955.tb05484.x","volume":"1","author":"Biggs, R.; Eveling, J.; Richards, G.","year":"1955","unstructured":"Biggs, R., Eveling, J., and Richards, G. (1955). Brit. J. Haemat., 1, 20.","journal-title":"Brit. J. Haemat"},{"key":"ref_3","first-page":"157","article-title":"The gene would result in a single plasma","volume":"168","author":"Borchgrevink, C.F.","year":"1960","unstructured":"The gene would result in a single plasma Borchgrevink, C. F. (1960). Acta med. scand., 168, 157.","journal-title":"Acta med. scand"},{"key":"ref_4","first-page":"2595","volume":"7","author":"Cornu, P.; Larrieu, M.J.","year":"1959","unstructured":"Cornu, P., and Larrieu, M. J. (1959). Path. et Biol., 7, 2595.","journal-title":"Path. et Biol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2141.1963.tb05457.x","volume":"9","author":"Cornu, P.; Larrieu, M.J.; Caen, J.; Bernard, J.","year":"1963","unstructured":"Cornu, P., and Larrieu, M. J., Caen, J., and Bernard, J. (1963). Brit. J. Haemat., 9, 189.","journal-title":"Brit. J. Haemat"},{"key":"ref_6","author":"Nilsson, I.M.; Blomback, M.; Von Francken, L.","year":"1957","unstructured":"Nilsson, I. M., Blomback, M., and Von Francken, L. (1957a). Acta","journal-title":"Acta"},{"key":"ref_7","first-page":"35","volume":"159","author":"med","year":"1957","unstructured":"med. scand., 159, 35. -, Jorpes, E., Blomback, B., and Johansson, S. A. (1957b). Ibid., 159, 179.","journal-title":"scand"},{"key":"ref_8","first-page":"35","volume":"159","author":"med","year":"1959","unstructured":"med. scand., 159, 35. -, Jorpes, E., Blomback, B., and Johansson, S. A., and Blomback, B. (1959). Ibid., 164, 263.","journal-title":"scand"},{"key":"ref_9","first-page":"144","volume":"30","author":"Piette, M.; Piette, C.","year":"1959","unstructured":"Piette, M., and Piette, C. (1959). Sang, 30, 144.","journal-title":"Sang"},{"key":"ref_10","first-page":"724","volume":"62","author":"Salzman, E.W.","year":"1963","unstructured":"Salzman, E. W. (1963). J. Lab. clin. Med., 62, 724.","journal-title":"J. Lab. clin. Med"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1056\/NEJM196507222730401","volume":"273","author":"Strauss, H.S.; Bloom, G.E.","year":"1965","unstructured":"Strauss, H. S., and Bloom, G. E. (1965). New Engi. J. Med., 273, 171.","journal-title":"New Engi. J. Med"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1136\/jcp.17.2.191","volume":"17","author":"Vainer, H.; Caen, J.","year":"1964","unstructured":"Vainer, H., and Caen, J. (1964). J. clin. Path., 17, 191.","journal-title":"J. clin. Path"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.20.2.190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:32:32Z","timestamp":1758789152000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.20.2.190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1967,3]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1967,3,1]]},"published-print":{"date-parts":[[1967,3]]}},"alternative-id":["10.1136\/jcp.20.2.190"],"URL":"https:\/\/doi.org\/10.1136\/jcp.20.2.190","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1967,3]]}}}