{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:47:41Z","timestamp":1761518861755,"version":"3.44.0"},"reference-count":7,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1967,11]]},"abstract":"<jats:p>Four cases of thyrotoxicosis are reported among 35 patients who had been given Thorotrast during the investigation of intracranial haemorrhage. For the group as a whole Thorotrast had been given between 11 and 31 years (mean 23\u00b74 years) before this study. Thyrotoxicosis occurred in four patients between six and 17 years (mean 11\u00b78 years) after the injection of Thorotrast. The fact that thyrotoxicosis did not occur in a small control group of patients who had had a subarachnoid haemorrhage and in whom Thorotrast had not been used at angiography suggests that Thorotrast may be of aetiological significance. In view of the known association between thyrotoxicosis and changes in the lymphoreticular system it is possible that the irradiation of this system by retained thorium has resulted in an abnormality of function which renders these patients more liable to the development of thyrotoxicosis.<\/jats:p>\n               <jats:p>A fifth patient developed non-toxic thyroid enlargement 16 years after Thorotrast angiography.<\/jats:p>","DOI":"10.1136\/jcp.20.6.892","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"892-895","source":"Crossref","is-referenced-by-count":6,"title":["Thyroid disease following the administration of Thorotrast"],"prefix":"10.1136","volume":"20","author":[{"given":"A. O.","family":"Langlands","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1967,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/B978-1-4832-3112-9.50009-8","volume":"6","author":"Dunham, C.L.","year":"1958","unstructured":"Dunham, C. L. (1958). Advanc. biol. med. Phys., 6, 175.","journal-title":"Advanc. biol. med. Phys"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1136\/bmj.3.5559.206","volume":"3","author":"Lancet","year":"1967","unstructured":"Lancet, 2, 201. Langlands. A. O., and Williamson, E. R. D. (1967). Brit. med. J., 3, 206.","journal-title":"Brit. med. J"},{"key":"ref_3","article-title":"Morbidity Statistics from General Practice","volume":"1","author":"Logan, W.P.D.; Cushion, A.A.","year":"1958","unstructured":"Logan, W. P. D., and Cushion, A. A. (1958). Morbidity Statistics from General Practice, vol. 1. (General Register Off. Studies on Medicine and Population Subjects, No. 14) H.M.S.O. London.","journal-title":"(General Register Off. Studies on Medicine and Population Subjects"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1016\/S0021-9258(19)70859-X","volume":"237","author":"McKenzie, J.M.","year":"1962","unstructured":"McKenzie, J. M. (1962). J. biol. Chem., 237, 3571.","journal-title":"J. biol. Chem"},{"key":"ref_5","first-page":"585","volume":"23","author":"MacMahon, H.E.; Murphy, A.S.; Bates, M.","year":"1947","unstructured":"MacMahon, H. E., Murphy, A. S., and Bates, M. 1. (1947). Amer. J. Path., 23, 585.","journal-title":"Amer. J. Path"},{"key":"ref_6","first-page":"441","volume":"58","author":"Schur, H.","year":"1908","unstructured":"Schur, H. (1908). Wien. med. Wschr., 58, 441.","journal-title":"Wien. med. Wschr"},{"key":"ref_7","article-title":"Textbook of Endocrinology","author":"Williams, R.H.","year":"1962","unstructured":"Williams, R. H. (1962). Textbook of Endocrinology, 2nd ed. Saunders, Philadelphia and London.","edition":"2nd ed"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.20.6.892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:03:54Z","timestamp":1758906234000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.20.6.892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1967,11]]},"references-count":7,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1967,11,1]]},"published-print":{"date-parts":[[1967,11]]}},"alternative-id":["10.1136\/jcp.20.6.892"],"URL":"https:\/\/doi.org\/10.1136\/jcp.20.6.892","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1967,11]]}}}