{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T14:00:05Z","timestamp":1785679205654,"version":"3.56.0"},"reference-count":14,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    To investigate whether extracutaneous infantile haemangioma-like tumours are immunohistochemically similar to cutaneous infantile haemangiomas.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Mammary, salivary gland, liver (one each), and placental (two cases) capillary haemangiomas and typical examples of cutaneous (eight cases) infantile haemangioma were investigated immunohistochemically for \u03b1\u00a0smooth muscle actin and Glut1, a proposed marker for the skin localised lesion. Positive internal controls included red blood cells, perineurium, trophoblast, and endothelial cells of the placental capillaries. Extralesional vessel endothelium acted as a negative control (except in the placenta). The liver haemangioma and both chorioangiomas presented in patients with Beckwith-Wiedemann syndrome.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The endothelial cells of all the vascular lesions were Glut1 positive. These were consistently surrounded by a rim of \u03b1\u00a0smooth muscle actin positive pericytic cells. Controls reacted appropriately.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    All infantile haemangiomas were immunohistochemically positive for Glut1: expression of this molecule was not limited to infantile haemangiomas of the skin. These tumours comprise proliferations of both endothelial and pericytic cells. The association with Beckwith-Wiedemann syndrome may provide a clue to the molecular genetics of infantile haemangioma.\n                  <\/jats:p>","DOI":"10.1136\/jcp.2003.012682","type":"journal-article","created":{"date-parts":[[2004,10,27]],"date-time":"2004-10-27T16:18:35Z","timestamp":1098893915000},"page":"1197-1200","source":"Crossref","is-referenced-by-count":42,"title":["Extracutaneous infantile haemangioma is also Glut1 positive"],"prefix":"10.1136","volume":"57","author":[{"given":"R M","family":"Drut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Drut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2004,10,27]]},"reference":[{"key":"2025120519012261000_57.11.1197.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(00)80192-6"},{"key":"2025120519012261000_57.11.1197.2","doi-asserted-by":"publisher","DOI":"10.1007\/s004030000190"},{"key":"2025120519012261000_57.11.1197.3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960315)62:2<145::AID-AJMG6>3.0.CO;2-V"},{"key":"2025120519012261000_57.11.1197.4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3109\/15513819209023296","volume":"12","year":"1992","journal-title":"Pediatr Pathol"},{"key":"2025120519012261000_57.11.1197.5","unstructured":"Ishak KG, Goodman ZD, Stocker JT. Tumors of the liver and intrahepatic bile ducts. Atlas of tumor pathology. 3rd series, Fascicle 31. Washington DC: AFIP, 2001."},{"key":"2025120519012261000_57.11.1197.6","unstructured":"Patterson K . Liver tumors and tumorlike masses. In: Parham DM, ed. Pediatric neoplasia: morphology and biology. Philadelphia: Lippincott-Raven Publishers, 1996:331\u00e2\u0080\u009361."},{"key":"2025120519012261000_57.11.1197.7","unstructured":"Rosen PP, Oberman HA. Tumors of the mammary gland. Atlas of tumor pathology. 3rd series, Fascicle 7. Washington DC: AFIP, 1992."},{"key":"2025120519012261000_57.11.1197.8","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1097\/00000478-198510000-00003","volume":"9","year":"1985","journal-title":"Am J Surg Pathol"},{"key":"2025120519012261000_57.11.1197.9","doi-asserted-by":"publisher","DOI":"10.1053\/adpa.2002.36662"},{"key":"2025120519012261000_57.11.1197.10","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2000.9036"},{"key":"2025120519012261000_57.11.1197.11","doi-asserted-by":"publisher","DOI":"10.1086\/338934"},{"key":"2025120519012261000_57.11.1197.12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.102185799"},{"key":"2025120519012261000_57.11.1197.13","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200106000-00002"},{"key":"2025120519012261000_57.11.1197.14","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s10024-003-2134-6","volume":"6","year":"2003","journal-title":"Pediatr Dev Pathol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2003.012682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T03:01:27Z","timestamp":1764990087000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2003.012682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10,27]]},"references-count":14,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2004,10,27]]},"published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1136\/jcp.2003.012682"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2003.012682","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10,27]]}}}