{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:14:34Z","timestamp":1778915674710,"version":"3.51.4"},"reference-count":43,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p>\n                    <jats:bold>Aims:<\/jats:bold>\n                    To determine gastric expression of trefoil family factor 2 (TFF2) and MUC6 in\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    positive and negative subjects, and its association with antralisation at the gastric incisura.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Gastric biopsies from the antrum, incisura, and body of 76 dyspeptic patients without ulcers were used for the determination of\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    infection, histological changes, and epithelial TFF2 and MUC6 expression.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    In the foveola, the rates of TFF2 and MUC6 immunostaining were greater in\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    infected (n \u200a=\u200a 27) than in uninfected patients (n \u200a=\u200a 49) at the antrum (59.3%\n                    <jats:italic>v<\/jats:italic>\n                    4.1% for TFF2 and 63.0%\n                    <jats:italic>v<\/jats:italic>\n                    4.1% for MUC6; both p &lt; 0.001) and incisura (44.4%\n                    <jats:italic>v<\/jats:italic>\n                    2.0% for TFF2 and 48.1%\n                    <jats:italic>v<\/jats:italic>\n                    0% for MUC6; both p &lt; 0.001). In the deeper glands, the rates were also greater in\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    infected than in uninfected patients at the incisura (85.2%\n                    <jats:italic>v<\/jats:italic>\n                    22.4% for both TFF2 and MUC6; p &lt; 0.001). Antral-type mucosa was present at the incisura in 28 of the 76 patients. TFF2 and MUC6 expression in the foveola and deeper glands was significantly associated with antral-type mucosa, independent of\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    status.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection increases the expression of TFF2 and MUC6 in the gastric epithelium. Aberrant TFF2 and MUC6 expression is associated with antralisation of gastric incisura.\n                  <\/jats:p>","DOI":"10.1136\/jcp.2003.015487","type":"journal-article","created":{"date-parts":[[2004,7,27]],"date-time":"2004-07-27T13:02:42Z","timestamp":1090933362000},"page":"861-866","source":"Crossref","is-referenced-by-count":26,"title":["Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in\n                    <i>Helicobacter pylori<\/i>\n                    infected gastric antrum, incisura, and body and its association with antralisation"],"prefix":"10.1136","volume":"57","author":[{"given":"H H-X","family":"Xia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S K","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W M","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S Y","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S T","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Elia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N A","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B C-Y","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2004,7,27]]},"reference":[{"key":"2025120521190928000_57.8.861.1","first-page":"A464","volume":"124","year":"2003","journal-title":"Gastroenterology"},{"key":"2025120521190928000_57.8.861.2","doi-asserted-by":"crossref","first-page":"B108","DOI":"10.1046\/j.1440-1746.2003.02788.x","volume":"18","year":"2003","journal-title":"J Gastroenterol Hepatol"},{"key":"2025120521190928000_57.8.861.3","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.6.792"},{"key":"2025120521190928000_57.8.861.4","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010915)92:6<1427::AID-CNCR1466>3.0.CO;2-L"},{"key":"2025120521190928000_57.8.861.5","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9247464"},{"key":"2025120521190928000_57.8.861.6","first-page":"475","volume":"6","year":"2000","journal-title":"World J Gastroenterol"},{"key":"2025120521190928000_57.8.861.7","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200103000-00007"},{"key":"2025120521190928000_57.8.861.8","first-page":"890","volume":"44","year":"2001","journal-title":"Gut"},{"key":"2025120521190928000_57.8.861.9","first-page":"G205","volume":"265","year":"1993","journal-title":"Am J Physiol"},{"key":"2025120521190928000_57.8.861.10","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050102"},{"key":"2025120521190928000_57.8.861.11","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.3.293"},{"key":"2025120521190928000_57.8.861.12","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/0016-5085(93)90956-D","volume":"105","year":"1993","journal-title":"Gastroenterology"},{"key":"2025120521190928000_57.8.861.13","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199904)187:5<541::AID-PATH283>3.0.CO;2-9"},{"key":"2025120521190928000_57.8.861.14","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90014-4"},{"key":"2025120521190928000_57.8.861.15","first-page":"2681","volume":"55","year":"1995","journal-title":"Cancer Res"},{"key":"2025120521190928000_57.8.861.16","first-page":"1003","volume":"59","year":"1999","journal-title":"Cancer Res"},{"key":"2025120521190928000_57.8.861.17","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199709)183:1<4::AID-PATH1099>3.0.CO;2-5"},{"key":"2025120521190928000_57.8.861.18","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(200003)190:4<437::AID-PATH547>3.0.CO;2-1"},{"key":"2025120521190928000_57.8.861.19","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00424-9"},{"key":"2025120521190928000_57.8.861.20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200212529"},{"key":"2025120521190928000_57.8.861.21","unstructured":"International Agency for Research on Cancer. 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