{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:27:15Z","timestamp":1788838035186,"version":"build-2803163510"},"reference-count":8,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:p>\n                    An 82 year old woman was admitted with worsening dyspnoea. Arterial blood gases were taken on air and revealed a pH of 7.39, with a partial pressure of CO\n                    <jats:sub>2<\/jats:sub>\n                    (pCO\n                    <jats:sub>2<\/jats:sub>\n                    ) of 1.2 kPa, pO\n                    <jats:sub>2<\/jats:sub>\n                    of 19.3 kPa, HCO\n                    <jats:sub>3<\/jats:sub>\n                    of 13.8 mmol\/litre, and base excess of \u221216.3 mmol\/litre: a compensated metabolic acidosis with hyperventilation induced hypocapnia, which is known to be a feature of lactic acidosis. There was also an increased anion gap ((Na140 + K4.0) \u2013 (Cl 106 + HCO\n                    <jats:sub>3<\/jats:sub>\n                    13.8) \u200a=\u200a 24.2 mEq\/litre (reference range, 7\u201316)), consistent with unmeasured cation. Lactate was measured and found to be raised at 3.33 mmol\/litre (reference range, 0.9\u20131.7). After exclusion of common causes of lactic acidosis Atorvastatin was stopped and her acid\u2013base balance returned to normal. Subsequently, thiamine was also shown to be deficient. The acidosis was thought to have been the result of a mitochondrial defect caused by a deficiency of two cofactors, namely: ubiquinone (as a result of inhibition by statin) and thiamine (as a result of dietary deficiency).\n                  <\/jats:p>","DOI":"10.1136\/jcp.2004.015958","type":"journal-article","created":{"date-parts":[[2004,8,27]],"date-time":"2004-08-27T19:26:16Z","timestamp":1093634776000},"page":"989-990","source":"Crossref","is-referenced-by-count":26,"title":["Statin precipitated lactic acidosis?"],"prefix":"10.1136","volume":"57","author":[{"given":"R","family":"Neale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T M","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Saweirs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2004,8,27]]},"reference":[{"key":"2025121220592331000_57.9.989.1","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1001\/archinte.1992.00400230129023","volume":"152","year":"1992","journal-title":"Arch Int Med"},{"key":"2025121220592331000_57.9.989.2","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200212000-00007"},{"key":"2025121220592331000_57.9.989.3","unstructured":"Cohen RD, Woods HF. Disturbances of acid\u00e2\u0080\u0093base homeostasis. In: Weatherall DJ, Ledingham JGG, Warrell DA, eds. Oxford textbook of medicine. 2nd ed. Oxford: Oxford University Press, 1989:9.164-9.175."},{"key":"2025121220592331000_57.9.989.4","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2002.127943"},{"key":"2025121220592331000_57.9.989.5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1996.04178.x"},{"key":"2025121220592331000_57.9.989.6","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2091-3-8"},{"key":"2025121220592331000_57.9.989.7","first-page":"25","volume":"31","year":"2001","journal-title":"Ann Clin Lab Sci"},{"key":"2025121220592331000_57.9.989.8","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10263"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2004.015958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:59:36Z","timestamp":1765601976000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2004.015958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8,27]]},"references-count":8,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2004,8,27]]},"published-print":{"date-parts":[[2004,9]]}},"alternative-id":["10.1136\/jcp.2004.015958"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2004.015958","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8,27]]}}}