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Observations from in vitro experiments and from animal models clearly established a state of chronic persistence through the formation of double stranded RNA, similar to findings reported in muscle biopsies of patients with CFS. Recent evidence not only confirmed the earlier studies, but also clarified the pathogenic role of viral RNA through antiviral treatment. This review summarises the available experimental and clinical evidence that supports the role of enterovirus in chronic fatigue syndrome.<\/jats:p>","DOI":"10.1136\/jcp.2004.020255","type":"journal-article","created":{"date-parts":[[2005,10,27]],"date-time":"2005-10-27T14:12:59Z","timestamp":1130422379000},"page":"1126-1132","source":"Crossref","is-referenced-by-count":73,"title":["The role of enterovirus in chronic fatigue syndrome"],"prefix":"10.1136","volume":"58","author":[{"given":"J K S","family":"Chia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2005,10,27]]},"reference":[{"key":"2025092510082492000_58.11.1126.1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-12-199412150-00009"},{"key":"2025092510082492000_58.11.1126.2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-3-25"},{"key":"2025092510082492000_58.11.1126.3","unstructured":"Komaroff AL, Gupta S, Salit IE. 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