{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T04:40:06Z","timestamp":1765082406161,"version":"3.46.0"},"reference-count":32,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Both\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    and gastro\u2013oesophageal reflux disease (GORD) may cause inflammation in cardiac mucosa. Intestinal metaplasia (IM) is found more often in GORD associated inflammation than in inflammation caused by\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    , especially in young individuals.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    To examine morphological differences in chronic inflammation in these two conditions by immunohistochemistry.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients\/Methods:<\/jats:bold>\n                    Tissue blocks from cardiac mucosa of patients &lt;45 years were available as follows: 10 patients with chronic inflammation of cardiac mucosa (carditis) and\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    gastritis (group 1); 10 patients with (possibly GORD related) carditis, but normal antrum and corpus (group 2); and 10 patients with non-inflamed cardiac mucosa and normal antrum and corpus (group 3). Haematoxylin and eosin staining and immunohistochemical staining for various inflammatory cells were performed for patients in groups 1 and 2 as follows: CD20 (B cells), CD3 (T cells), CD4 (T helper cells), CD8 (T suppressor cells), CD163 (macrophages), CD138 (plasma cells), and CD117 (mast cells). For all patients, cytokeratin 7\/20 (CK7\/20) staining was performed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    No clear differences were seen in the morphology of chronic inflammation between groups 1 and 2. In both, plasma cells were most abundant. CK7\/20 staining showed no differences between these groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    negative (possibly GORD associated) and\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    related carditis cannot be distinguished on a morphological basis. The stronger tendency towards IM in the first entity cannot be explained by differences in the type of inflammation. Barrett-type CK7\/20 staining seems typical for cardiac mucosa, irrespective of the type of inflammation or presence of IM.\n                  <\/jats:p>","DOI":"10.1136\/jcp.2004.020966","type":"journal-article","created":{"date-parts":[[2005,3,24]],"date-time":"2005-03-24T13:27:42Z","timestamp":1111670862000},"page":"376-381","source":"Crossref","is-referenced-by-count":0,"title":["Inflammation and cytokeratin 7\/20 staining of cardiac mucosa in young patients with and without\n                    <i>Helicobacter pylori<\/i>\n                    infection"],"prefix":"10.1136","volume":"58","author":[{"given":"A","family":"Oksanen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Sankila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"von 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