{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T09:05:29Z","timestamp":1765703129923,"version":"3.48.0"},"reference-count":45,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    In the USA, atrophic gastritis and gastric cancer are rare, whereas gastro-oesophageal reflux disease (GERD) is common. Infection with\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    , especially a CagA positive strain, is unusual in patients with GERD\/Barrett\u2019s oesophagus in the USA.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    To examine the relation between Barrett\u2019s oesophagus and CagA positive\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    in Colombia, a country with a high prevalence of CagA positive\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    associated atrophic gastritis and gastric cancer.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    and CagA status was determined among Colombian patients with long segment Barrett\u2019s oesophagus and a control group with simple\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    gastritis.\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    status was determined using a triple stain and CagA status was determined by immunohistochemistry using a specific rabbit anti-CagA serum.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Gastric and oesophageal mucosal biopsies were obtained from 51 patients\u201439 men (mean age, 57.8 years; SD, 13.1) and 12 women (mean age, 51.8 years; SD, 14.4)\u2014with documented long segment Barrett\u2019s oesophagus. The results were compared with 24 Colombian patients with\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    gastritis without oesophageal disease. Thirty two patients with Barrett\u2019s oesophagus had active\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    infection. CagA status was evaluated in a subset of 23\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    infected patients with Barrett\u2019s oesophagus, and was positive in eight of these patients compared with 19 of 24 controls (p \u200a=\u200a 0.01).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Although most Colombian patients with Barrett\u2019s oesophagus had\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    infection, CagA positive infections were unusual. These data illustrate how consistent corpus inflammation reduces acid secretion, which prevents Barrett\u2019s oesophagus among those with abnormal gastro-oesophageal reflux barriers.\n                  <\/jats:p>","DOI":"10.1136\/jcp.2004.022251","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T18:53:07Z","timestamp":1109357587000},"page":"259-262","source":"Crossref","is-referenced-by-count":11,"title":["CagA in Barrett\u2019s oesophagus in Colombia, a country with a high prevalence of gastric cancer"],"prefix":"10.1136","volume":"58","author":[{"given":"M","family":"Kudo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Gutierrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H M T","family":"El-Zimaity","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Cardona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z Z","family":"Nurgalieva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D Y","family":"Graham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2005,2,25]]},"reference":[{"key":"2025121401024918000_58.3.259.1","doi-asserted-by":"publisher","DOI":"10.1055\/s-1999-13643"},{"key":"2025121401024918000_58.3.259.2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2050.2002.00216.x"},{"key":"2025121401024918000_58.3.259.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(02)00016-X"},{"key":"2025121401024918000_58.3.259.4","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.3.368"},{"key":"2025121401024918000_58.3.259.5","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90011-6"},{"key":"2025121401024918000_58.3.259.6","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022815902105"},{"key":"2025121401024918000_58.3.259.7","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/S0025-6196(12)65415-9","volume":"63","year":"1988","journal-title":"Mayo Clin Proc"},{"key":"2025121401024918000_58.3.259.8","doi-asserted-by":"crossref","first-page":"S704","DOI":"10.1093\/clinids\/13.Supplement_8.S704","volume":"13","year":"1991","journal-title":"Rev Infect Dis"},{"key":"2025121401024918000_58.3.259.9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/dote\/10.1.38","volume":"10","year":"1997","journal-title":"Dis Esophagus"},{"key":"2025121401024918000_58.3.259.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.162_b.x"},{"key":"2025121401024918000_58.3.259.11","first-page":"215","volume":"22","year":"1992","journal-title":"Acta Gastroenterol Latinoam"},{"key":"2025121401024918000_58.3.259.12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01245.x"},{"key":"2025121401024918000_58.3.259.13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07533.x"},{"key":"2025121401024918000_58.3.259.14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.1998.08031.x"},{"key":"2025121401024918000_58.3.259.15","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/0016-5085(91)90644-Z","volume":"100","year":"1991","journal-title":"Gastroenterology"},{"key":"2025121401024918000_58.3.259.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(02)00083-4"},{"key":"2025121401024918000_58.3.259.17","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(97)90052-6"},{"key":"2025121401024918000_58.3.259.18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02305.x"},{"key":"2025121401024918000_58.3.259.19","doi-asserted-by":"publisher","DOI":"10.1159\/000007801"},{"key":"2025121401024918000_58.3.259.20","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70364-6"},{"key":"2025121401024918000_58.3.259.21","unstructured":"Breuer T, Malaty HM, Graham DY. 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