{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:35:37Z","timestamp":1784194537219,"version":"3.55.0"},"reference-count":16,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    To report two examples of an angiocentric immunoproliferative lesion (AIL) and angiocentric angiodestructive lymphoma (AL) presenting in lymph nodes in children. Most commonly involving extranodal sites, AIL\/AL rarely presents in the spleen and lymph nodes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods\/Results:<\/jats:bold>\n                    Case 1 presented as a cervical lymphadenopathy in a 3 year old girl being treated for pre-B cell acute lymphoblastic leukaemia. Histological and immunohistochemistry studies revealed an Epstein-Barr virus positive (EBV+), large B cell (CD20 and CD30+) AIL with large areas of necrosis, the whole resembling lymphomatoid granulomatosis. Case 2 presented as a large supraclavicular lymphadenopathy in a 13 year old boy. Histology and immunohistochemistry revealed an EBV\u2013, large T cell (CD45RO, CD56, and CD30+) AL, presenting the features of so called angiocentric T cell\/natural killer cell lymphoma, nasal type.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The term AIL\/AL refers to a heterogeneous group of conditions not unique to a particular type of lymphoid cell. These lesions are easily recognised by the histopathologist because of their extremely unusual angiocentric pattern. Although rare, AIL\/AL may present as nodal lesions in children ab initio.\n                  <\/jats:p>","DOI":"10.1136\/jcp.2004.022475","type":"journal-article","created":{"date-parts":[[2005,4,27]],"date-time":"2005-04-27T16:16:29Z","timestamp":1114618589000},"page":"550-552","source":"Crossref","is-referenced-by-count":9,"title":["Angiocentric immunoproliferative lesion and angiocentric lymphoma of lymph node in children. A report of two cases"],"prefix":"10.1136","volume":"58","author":[{"given":"R","family":"Drut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R M","family":"Drut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2005,4,27]]},"reference":[{"key":"2025120619115404000_58.5.550.1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3109\/15513818809041574","volume":"8","year":"1988","journal-title":"Pediatr Pathol"},{"key":"2025120619115404000_58.5.550.2","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/00000478-199406000-00006","volume":"18","year":"1994","journal-title":"Am J Surg Pathol"},{"key":"2025120619115404000_58.5.550.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(03)00127-8"},{"key":"2025120619115404000_58.5.550.4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/ajcp\/106.1.69","volume":"106","year":"1996","journal-title":"Am J Clin Pathol"},{"key":"2025120619115404000_58.5.550.5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/ajh.2830300210","volume":"30","year":"1989","journal-title":"Am J Hematol"},{"key":"2025120619115404000_58.5.550.6","unstructured":"Jaffe ES. Post-thymic lymphoid neoplasia. In: Jaffe ES, ed. Surgical pathology of the lymph node and related organs. Major problems in pathology, Vol. 16. Philadelphia: WB Saunders, 1985, 218\u00e2\u0080\u0093248, 329\u00e2\u0080\u0093356."},{"key":"2025120619115404000_58.5.550.7","first-page":"4280","volume":"41","year":"1981","journal-title":"Cancer Res"},{"key":"2025120619115404000_58.5.550.8","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1200\/JCO.1990.8.3.378","volume":"8","year":"1990","journal-title":"J Clin Oncol"},{"key":"2025120619115404000_58.5.550.9","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199701000-00012"},{"key":"2025120619115404000_58.5.550.10","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199906)32:6<447::AID-MPO12>3.0.CO;2-1"},{"key":"2025120619115404000_58.5.550.11","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702727"},{"key":"2025120619115404000_58.5.550.12","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.7.555"},{"key":"2025120619115404000_58.5.550.13","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1097\/00000478-199511000-00011","volume":"19","year":"1995","journal-title":"Am J Surg Pathol"},{"key":"2025120619115404000_58.5.550.14","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/00000478-199205000-00002","volume":"16","year":"1992","journal-title":"Am J Surg Pathol"},{"key":"2025120619115404000_58.5.550.15","unstructured":"Jaffe ES, Wilson WH. Lymphomatoid granulomatosis. In: Jaffe ES, Harris NL, Stein H, et al, eds. Pathology and genetics of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press, 2001:185\u00e2\u0080\u00937."},{"key":"2025120619115404000_58.5.550.16","unstructured":"Chan JKC, Jaffe ES, Ralfkiaer E. Extranodal NK\/T-cell lymphoma, nasal type. In: Jaffe ES, Harris NL, Stein H, et al, eds. Pathology and genetics of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press, 2001:204\u00e2\u0080\u00937."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2004.022475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:12:06Z","timestamp":1765077126000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2004.022475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,27]]},"references-count":16,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2005,4,27]]},"published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1136\/jcp.2004.022475"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2004.022475","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,27]]}}}