{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:57:34Z","timestamp":1789876654782,"version":"4.0.1"},"reference-count":32,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p>\n                    <jats:bold>Aims:<\/jats:bold>\n                    To investigate SOCS-2 (suppressor of cytokine signalling 2) protein expression in breast carcinoma samples in relation to biopathological parameters and survival.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    A polyclonal antibody against SOCS-2 was used to study 50 archival breast carcinoma samples, collected from 1993 to 1995. The presence of SOCS-2 protein was investigated in relation to clinical and biological parameters used in breast cancer pathology. Fluorescence in situ hybridisation (FISH) was used to study whether SOCS-2 expression was related to SOCS-2 gene copy number.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    SOCS-2 protein was expressed in 34 of 50 breast carcinoma samples and was positively associated with low grade, low nuclear grade, and p27 protein. SOCS-2 expression was inversely related to Ki-67, cyclin A, retinoblastoma protein (pRb), and the epidermal growth factor receptor (EGFR). No relation with overall survival was demonstrated. SOCS-2 amplification was found in three samples. No relation between the number of FISH signals and SOCS-2 expression was found.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The significant correlation seen between SOCS-2 expression, grade, nuclear grade, p27, Ki-67, cyclin A, pRb, and EGFR labelling strongly supports the hypothesis that SOCS-2 loss might be related to cell proliferation and tumour growth in breast carcinoma. Gene copy number changes did not seem to play a role in SOCS-2 regulation and expression; other mechanisms might be involved and deserve further study.\n                  <\/jats:p>","DOI":"10.1136\/jcp.2004.024919","type":"journal-article","created":{"date-parts":[[2005,9,27]],"date-time":"2005-09-27T12:28:29Z","timestamp":1127824109000},"page":"1046-1050","source":"Crossref","is-referenced-by-count":41,"title":["Suppressor of cytokine signalling 2 (SOCS-2) expression in breast carcinoma"],"prefix":"10.1136","volume":"58","author":[{"given":"F","family":"Farabegoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Ceccarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Santini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Taffurelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2005,9,27]]},"reference":[{"key":"2025121404004930000_58.10.1046.1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0463.2002.1101201.x"},{"key":"2025121404004930000_58.10.1046.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00701-8"},{"key":"2025121404004930000_58.10.1046.3","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000801"},{"key":"2025121404004930000_58.10.1046.4","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1189\/jlb.1003507","volume":"75","year":"2004","journal-title":"J Leukoc Biol"},{"key":"2025121404004930000_58.10.1046.5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.091003.090312"},{"key":"2025121404004930000_58.10.1046.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.05.012"},{"key":"2025121404004930000_58.10.1046.7","first-page":"29","volume":"1","year":"2001","journal-title":"Nat Genet"},{"key":"2025121404004930000_58.10.1046.8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601039"},{"key":"2025121404004930000_58.10.1046.9","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20521"},{"key":"2025121404004930000_58.10.1046.10","first-page":"2784","volume":"10","year":"2003","journal-title":"Blood"},{"key":"2025121404004930000_58.10.1046.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05107.x"},{"key":"2025121404004930000_58.10.1046.12","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3816\/CLC.2004.n.015","volume":"5","year":"2004","journal-title":"Clin Lung Cancer"},{"key":"2025121404004930000_58.10.1046.13","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.5.1766"},{"key":"2025121404004930000_58.10.1046.14","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.05.016"},{"key":"2025121404004930000_58.10.1046.15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601115"},{"key":"2025121404004930000_58.10.1046.16","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207787"},{"key":"2025121404004930000_58.10.1046.17","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh083"},{"key":"2025121404004930000_58.10.1046.18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0337600100"},{"key":"2025121404004930000_58.10.1046.19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.191367098"},{"key":"2025121404004930000_58.10.1046.20","doi-asserted-by":"publisher","DOI":"10.1677\/erc.0.0110085"},{"key":"2025121404004930000_58.10.1046.21","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.1999.0657"},{"key":"2025121404004930000_58.10.1046.22","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/ajcp\/78.6.806","volume":"78","year":"1982","journal-title":"Am J Clin Pathol"},{"key":"2025121404004930000_58.10.1046.23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1991.tb00229.x"},{"key":"2025121404004930000_58.10.1046.24","first-page":"120","volume":"9","year":"1996","journal-title":"Mod Pathol"},{"key":"2025121404004930000_58.10.1046.25","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1136\/jcp.51.11.818","volume":"51","year":"1998","journal-title":"J Clin Pathol"},{"key":"2025121404004930000_58.10.1046.26","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990621)84:3<273::AID-IJC13>3.0.CO;2-7"},{"key":"2025121404004930000_58.10.1046.27","doi-asserted-by":"publisher","DOI":"10.1007\/BF00500631"},{"key":"2025121404004930000_58.10.1046.28","first-page":"1959","volume":"51","year":"1991","journal-title":"Cancer Res"},{"key":"2025121404004930000_58.10.1046.29","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1311"},{"key":"2025121404004930000_58.10.1046.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2004.03.026"},{"key":"2025121404004930000_58.10.1046.31","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408575200"},{"key":"2025121404004930000_58.10.1046.32","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20307"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2004.024919","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T12:01:00Z","timestamp":1765713660000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2004.024919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,27]]},"references-count":32,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2005,9,27]]},"published-print":{"date-parts":[[2005,10]]}},"alternative-id":["10.1136\/jcp.2004.024919"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2004.024919","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9,27]]}}}