{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:10:55Z","timestamp":1777590655703,"version":"3.51.4"},"reference-count":15,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Vascular tumours such as Kaposi\u2019s sarcoma and capillary haemangioma are characterised by abnormal vascularisation and proliferation of endothelial cells or neoplastic cells. Adrenomedullin, a potent vasodilative peptide, and its receptor, calcitonin receptor-like receptor (CRLR), play an important part in angiogenesis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    To establish whether this system also plays a part in vascular diseases, showing abnormal proliferation such as vascular tumours.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    CRLR expression was investigated in several specimens of Kaposi\u2019s sarcoma and other vascular tumours, using immunohistochemical analysis with a previously described CRLR-specific polyclonal antibody and reverse transcriptase-polymerase chain reaction.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Intense and specific CRLR-immunoreactive staining of neoplastic cells was observed in all specimens, which was of greater intensity than similar staining of adjacent normal endothelium.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    CRLR is expressed in vascular tumours and, with adrenomedullin, may have a role in neoplastic vascular growth.\n                  <\/jats:p>","DOI":"10.1136\/jcp.2005.026930","type":"journal-article","created":{"date-parts":[[2006,10,4]],"date-time":"2006-10-04T13:38:54Z","timestamp":1159969134000},"page":"1104-1107","source":"Crossref","is-referenced-by-count":15,"title":["Expression of calcitonin receptor-like receptor in human vascular 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