{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:41:28Z","timestamp":1782891688826,"version":"3.54.5"},"reference-count":126,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p>Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is the third most common non-Hodgkin lymphoma subtype, accounting for around 6\u20138% of all non-Hodgkin lymphomas in the Western hemisphere. Although MALT lymphomas are clinically indolent, the disease is typically chronic, requiring long-term clinical surveillance and, often, repeated biopsies. Pathologists thus play a central role in the diagnosis and management of these patients. The optimal diagnosis and management of a MALT lymphoma requires careful integration of morphological, immunohistochemical and molecular information, together with close cooperation with the clinician treating the patient. This review discusses recent developments in the molecular pathogenesis of MALT lymphoma and provides strategies for integrating this information into daily pathological practice.<\/jats:p>","DOI":"10.1136\/jcp.2005.031146","type":"journal-article","created":{"date-parts":[[2006,9,2]],"date-time":"2006-09-02T00:38:22Z","timestamp":1157157502000},"page":"361-372","source":"Crossref","is-referenced-by-count":142,"title":["Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists"],"prefix":"10.1136","volume":"60","author":[{"given":"Chris M","family":"Bacon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Qing","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2006,9,1]]},"reference":[{"key":"2024053009442158000_60.4.361.1","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1182\/blood.V89.11.3909","volume":"89","year":"1997","journal-title":"Blood"},{"key":"2024053009442158000_60.4.361.2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1409"},{"key":"2024053009442158000_60.4.361.3","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92035-Z"},{"key":"2024053009442158000_60.4.361.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405053301803"},{"key":"2024053009442158000_60.4.361.5","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91408-E"},{"key":"2024053009442158000_60.4.361.6","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711690208"},{"key":"2024053009442158000_60.4.361.7","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh102"},{"key":"2024053009442158000_60.4.361.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04993.x"},{"key":"2024053009442158000_60.4.361.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031887"},{"key":"2024053009442158000_60.4.361.10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.07.083"},{"key":"2024053009442158000_60.4.361.11","doi-asserted-by":"publisher","DOI":"10.1002\/path.1984"},{"key":"2024053009442158000_60.4.361.12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2332"},{"key":"2024053009442158000_60.4.361.13","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.49.2.107"},{"key":"2024053009442158000_60.4.361.14","unstructured":"Isaacson PG, Norton AJ. Extranodal lymphomas. Edinburgh: Churchill Livingstone, 1994."},{"key":"2024053009442158000_60.4.361.15","unstructured":"Isaacson PG, Muller Hermelink HK, Piris MA, et al. Extranodal marginal zone lymphoma of muocsa-associated lymphoid tissue (MALT lymphoma). In: Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. World Health Organisation Classification of Tumours. Pathology and genetics of tumours of haematopoietic and lymphoid tissues Lyon: IARC Press, 2001:157\u201360."},{"key":"2024053009442158000_60.4.361.16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1987.tb02654.x"},{"key":"2024053009442158000_60.4.361.17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/ajcp\/105.1.31","volume":"105","year":"1996","journal-title":"Am J Clin Pathol"},{"key":"2024053009442158000_60.4.361.18","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199802000-00008"},{"key":"2024053009442158000_60.4.361.19","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1097\/00000478-199012000-00001","volume":"14","year":"1990","journal-title":"Am J Surg Pathol"},{"key":"2024053009442158000_60.4.361.20","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91409-F"},{"key":"2024053009442158000_60.4.361.21","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200108000-00003"},{"key":"2024053009442158000_60.4.361.22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1995.tb00271.x"},{"key":"2024053009442158000_60.4.361.23","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.8.642"},{"key":"2024053009442158000_60.4.361.24","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(88)80259-4"},{"key":"2024053009442158000_60.4.361.25","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199505000-00004"},{"key":"2024053009442158000_60.4.361.26","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(97)90161-1"},{"key":"2024053009442158000_60.4.361.27","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)98024-1"},{"key":"2024053009442158000_60.4.361.28","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"2024053009442158000_60.4.361.29","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/S0046-8177(88)80287-9","volume":"19","year":"1988","journal-title":"Hum Pathol"},{"key":"2024053009442158000_60.4.361.30","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200005000-00001"},{"key":"2024053009442158000_60.4.361.31","first-page":"1153","volume":"136","year":"1990","journal-title":"Am J Pathol"},{"key":"2024053009442158000_60.4.361.32","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199109000-00001"},{"key":"2024053009442158000_60.4.361.33","first-page":"43","volume":"141","year":"1992","journal-title":"Am J Pathol"},{"key":"2024053009442158000_60.4.361.34","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90838-G"},{"key":"2024053009442158000_60.4.361.35","doi-asserted-by":"publisher","DOI":"10.1080\/00313020310001648404"},{"key":"2024053009442158000_60.4.361.36","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403202"},{"key":"2024053009442158000_60.4.361.37","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404049"},{"key":"2024053009442158000_60.4.361.38","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.7.2541"},{"key":"2024053009442158000_60.4.361.39","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.080523"},{"key":"2024053009442158000_60.4.361.40","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1999.00628.x"},{"key":"2024053009442158000_60.4.361.41","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90446-4"},{"key":"2024053009442158000_60.4.361.42","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1182\/blood.V87.4.1255.bloodjournal8741255","volume":"87","year":"1996","journal-title":"Blood"},{"key":"2024053009442158000_60.4.361.43","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200307000-00002"},{"key":"2024053009442158000_60.4.361.44","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1093\/ajcp\/106.4.498","volume":"106","year":"1996","journal-title":"Am J Clin Pathol"},{"key":"2024053009442158000_60.4.361.45","doi-asserted-by":"publisher","DOI":"10.1016\/S1568-9972(03)00102-2"},{"key":"2024053009442158000_60.4.361.46","doi-asserted-by":"publisher","DOI":"10.1038\/nri1352"},{"key":"2024053009442158000_60.4.361.47","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2004.08.022"},{"key":"2024053009442158000_60.4.361.48","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1182\/blood.V93.11.3601","volume":"93","year":"1999","journal-title":"Blood"},{"key":"2024053009442158000_60.4.361.49","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203018"},{"key":"2024053009442158000_60.4.361.50","first-page":"6205","volume":"59","year":"1999","journal-title":"Cancer Res"},{"key":"2024053009442158000_60.4.361.51","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M009984200"},{"key":"2024053009442158000_60.4.361.52","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3502"},{"key":"2024053009442158000_60.4.361.53","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403501"},{"key":"2024053009442158000_60.4.361.54","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S0002-9440(10)64988-7","volume":"156","year":"2000","journal-title":"Am J Pathol"},{"key":"2024053009442158000_60.4.361.55","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/S0002-9440(10)65499-5","volume":"155","year":"1999","journal-title":"Am J Pathol"},{"key":"2024053009442158000_60.4.361.56","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000067421.92575.6E"},{"key":"2024053009442158000_60.4.361.57","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.4.1182"},{"key":"2024053009442158000_60.4.361.58","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008202303666"},{"key":"2024053009442158000_60.4.361.59","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64157-0"},{"key":"2024053009442158000_60.4.361.60","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.1.3"},{"key":"2024053009442158000_60.4.361.61","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33047"},{"key":"2024053009442158000_60.4.361.62","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1182\/blood.V96.6.2215","volume":"96","year":"2000","journal-title":"Blood"},{"key":"2024053009442158000_60.4.361.63","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.4.1398"},{"key":"2024053009442158000_60.4.361.64","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64630-5"},{"key":"2024053009442158000_60.4.361.65","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-09-2963"},{"key":"2024053009442158000_60.4.361.66","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3236"},{"key":"2024053009442158000_60.4.361.67","doi-asserted-by":"publisher","DOI":"10.1002\/path.1715"},{"key":"2024053009442158000_60.4.361.68","doi-asserted-by":"publisher","DOI":"10.1038\/8767"},{"key":"2024053009442158000_60.4.361.69","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80957-5"},{"key":"2024053009442158000_60.4.361.70","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/sj.leu.2403644","volume":"19","year":"2005","journal-title":"Leukemia"},{"key":"2024053009442158000_60.4.361.71","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403813"},{"key":"2024053009442158000_60.4.361.72","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213275.60962.2a"},{"key":"2024053009442158000_60.4.361.73","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404244"},{"key":"2024053009442158000_60.4.361.74","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20278"},{"key":"2024053009442158000_60.4.361.75","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90113-2"},{"key":"2024053009442158000_60.4.361.76","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(02)00651-4"},{"key":"2024053009442158000_60.4.361.77","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.018"},{"key":"2024053009442158000_60.4.361.78","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/0016-5085(92)91723-H","volume":"102","year":"1992","journal-title":"Gastroenterology"},{"key":"2024053009442158000_60.4.361.79","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/oxfordjournals.annonc.a058869","volume":"5","year":"1994","journal-title":"Ann Oncol"},{"key":"2024053009442158000_60.4.361.80","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.4.454"},{"key":"2024053009442158000_60.4.361.81","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9322502"},{"key":"2024053009442158000_60.4.361.82","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-131-2-199907200-00003"},{"key":"2024053009442158000_60.4.361.83","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.3.297"},{"key":"2024053009442158000_60.4.361.84","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/0016-5085(91)90063-Q","volume":"101","year":"1991","journal-title":"Gastroenterology"},{"key":"2024053009442158000_60.4.361.85","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05460.x"},{"key":"2024053009442158000_60.4.361.86","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1182\/blood.V95.3.802.003k19_802_806","volume":"95","year":"2000","journal-title":"Blood"},{"key":"2024053009442158000_60.4.361.87","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1200\/JCO.1999.17.4.1254","volume":"17","year":"1999","journal-title":"J Clin Oncol"},{"key":"2024053009442158000_60.4.361.88","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1279"},{"key":"2024053009442158000_60.4.361.89","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1308"},{"key":"2024053009442158000_60.4.361.90","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1182\/blood.V96.2.410.014k22_410_419","volume":"96","year":"2000","journal-title":"Blood"},{"key":"2024053009442158000_60.4.361.91","doi-asserted-by":"crossref","unstructured":"Thieblemont C. Clinical presentation and management of marginal zone lymphomas. Hematology 2005 (Am Soc Hematol Educ Program) 2005:307\u201313.","DOI":"10.1182\/asheducation-2005.1.307"},{"key":"2024053009442158000_60.4.361.92","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1200\/JCO.1997.15.4.1624","volume":"15","year":"1997","journal-title":"J Clin Oncol"},{"key":"2024053009442158000_60.4.361.93","doi-asserted-by":"publisher","DOI":"10.1309\/MECJ-GLK1-WEBW-UEVE"},{"key":"2024053009442158000_60.4.361.94","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70026-X"},{"key":"2024053009442158000_60.4.361.95","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/oxfordjournals.annonc.a059184","volume":"6","year":"1995","journal-title":"Ann Oncol"},{"key":"2024053009442158000_60.4.361.96","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1200\/JCO.2001.19.7.2041","volume":"19","year":"2001","journal-title":"J Clin Oncol"},{"key":"2024053009442158000_60.4.361.97","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21152"},{"key":"2024053009442158000_60.4.361.98","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji277"},{"key":"2024053009442158000_60.4.361.99","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH811>3.0.CO;2-Z"},{"key":"2024053009442158000_60.4.361.100","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00895.x"},{"key":"2024053009442158000_60.4.361.101","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00000478-200101000-00011","volume":"25","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"2024053009442158000_60.4.361.102","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3167"},{"key":"2024053009442158000_60.4.361.103","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0004"},{"key":"2024053009442158000_60.4.361.104","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.05.6150"},{"key":"2024053009442158000_60.4.361.105","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03571-6"},{"key":"2024053009442158000_60.4.361.106","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.660"},{"key":"2024053009442158000_60.4.361.107","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.08.128"},{"key":"2024053009442158000_60.4.361.108","doi-asserted-by":"publisher","DOI":"10.1159\/000079502"},{"key":"2024053009442158000_60.4.361.109","first-page":"3944","volume":"57","year":"1997","journal-title":"Cancer Res"},{"key":"2024053009442158000_60.4.361.110","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.081117"},{"key":"2024053009442158000_60.4.361.111","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.3903"},{"key":"2024053009442158000_60.4.361.112","doi-asserted-by":"publisher","DOI":"10.1136\/gut.53.1.34"},{"key":"2024053009442158000_60.4.361.113","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2282"},{"key":"2024053009442158000_60.4.361.114","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.5.621"},{"key":"2024053009442158000_60.4.361.115","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.11.1656"},{"key":"2024053009442158000_60.4.361.116","first-page":"36","volume":"47","year":"2000","journal-title":"J Med Invest"},{"key":"2024053009442158000_60.4.361.117","first-page":"1098","volume":"343","year":"1994","journal-title":"Lancet"},{"key":"2024053009442158000_60.4.361.118","doi-asserted-by":"crossref","first-page":"B106","DOI":"10.1007\/PL00022770","volume":"80","year":"2001","journal-title":"Ann Hematol"},{"key":"2024053009442158000_60.4.361.119","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1200\/JCO.2001.19.6.1600","volume":"19","year":"2001","journal-title":"J Clin Oncol"},{"key":"2024053009442158000_60.4.361.120","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-005-1217-3"},{"key":"2024053009442158000_60.4.361.121","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi277"},{"key":"2024053009442158000_60.4.361.122","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-2559.1995.tb01522.x","volume":"27","year":"1995","journal-title":"Histopathology"},{"key":"2024053009442158000_60.4.361.123","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199705000-00001"},{"key":"2024053009442158000_60.4.361.124","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310000582"},{"key":"2024053009442158000_60.4.361.125","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3748\/wjg.v7.i2.248","volume":"7","year":"2001","journal-title":"World J Gastroenterol"},{"key":"2024053009442158000_60.4.361.126","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi242"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2005.031146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T21:29:34Z","timestamp":1717104574000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2005.031146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,1]]},"references-count":126,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,4,3]]},"published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.1136\/jcp.2005.031146"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2005.031146","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,1]]}}}