{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:24:18Z","timestamp":1765974258019,"version":"3.48.0"},"reference-count":14,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>\n                    Haemophagocytic lymphohistiocytosis (HLH) comprises primary and secondary forms; the secondary form is most commonly triggered by the Epstein\u2013Barr virus (EBV; EBV-HLH). Patients with EBV-HLH usually exhibit oligoclonal or monoclonal T cell proliferation, which may mimic T cell lymphoproliferative disorder (T-LPD). This article reports on EBV-HLH in a 17-month-old girl with an extreme surge of reactive T lymphocytosis (absolute count 167\u00d710\n                    <jats:sup>9<\/jats:sup>\n                    \/l) with CD5 down regulation. Bone marrow aspirate and trephine contained florid haemophagocytosis and massive infiltration of CD3+ Epstein\u2013Barr virus-encoded RNA+ lymphocytes, as seen by double labelling. These lymphocytes were monoclonal for EBV and T cell receptor \u03b3 chain gene rearrangement. The patient responded dramatically to intravenous immunoglobulin, interferon \u03b12b, ganciclovir and prednisolone, suggesting restoration of her immune system and eradication of the clonal T cells through these immunoregulatory agents. Thus, careful clinicopathological correlation is warranted in the interpretation of immunophenotyping and clonality data in T cell proliferation in association with EBV-HLH to avoid erroneous diagnosis of T-LPD.\n                  <\/jats:p>","DOI":"10.1136\/jcp.2005.034371","type":"journal-article","created":{"date-parts":[[2007,1,9]],"date-time":"2007-01-09T13:29:01Z","timestamp":1168349341000},"page":"101-103","source":"Crossref","is-referenced-by-count":38,"title":["Massive expansion of EBV+ monoclonal T cells with CD5 down regulation in EBV-associated haemophagocytic lymphohistiocytosis"],"prefix":"10.1136","volume":"60","author":[{"given":"Ming-Tsan","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Mei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Jen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woan-Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Yung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Yang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Sung","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2007,1,9]]},"reference":[{"key":"2025121407505052000_60.1.101.1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S1040-8428(02)00117-8","volume":"44","year":"2002","journal-title":"Crit Rev Oncol Hematol"},{"key":"2025121407505052000_60.1.101.2","first-page":"29","volume":"18","year":"1991","journal-title":"Semin Oncol"},{"key":"2025121407505052000_60.1.101.3","doi-asserted-by":"publisher","DOI":"10.1038\/nm0896-906"},{"key":"2025121407505052000_60.1.101.4","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1172\/JCI116721","volume":"92","year":"1993","journal-title":"J Clin Invest"},{"key":"2025121407505052000_60.1.101.5","first-page":"1869","volume":"93","year":"1999","journal-title":"Blood"},{"key":"2025121407505052000_60.1.101.6","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1182\/blood.V96.2.443","volume":"96","year":"2000","journal-title":"Blood"},{"key":"2025121407505052000_60.1.101.7","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1365-2141.1994.tb08309.x","volume":"87","year":"1994","journal-title":"Br J Haematol"},{"key":"2025121407505052000_60.1.101.8","first-page":"173","volume":"1","year":"1992","journal-title":"Diagn Mol Pathol"},{"key":"2025121407505052000_60.1.101.9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3296"},{"key":"2025121407505052000_60.1.101.10","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.10003"},{"key":"2025121407505052000_60.1.101.11","doi-asserted-by":"publisher","DOI":"10.1309\/QF6N-VAQW-N74H-4JE2"},{"key":"2025121407505052000_60.1.101.12","doi-asserted-by":"publisher","DOI":"10.1309\/VC7M-24UC-5VG7-EUEC"},{"key":"2025121407505052000_60.1.101.13","doi-asserted-by":"publisher","DOI":"10.1080\/003130202760120463"},{"key":"2025121407505052000_60.1.101.14","doi-asserted-by":"publisher","DOI":"10.1080\/10428190210176"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2005.034371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T15:50:58Z","timestamp":1765727458000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2005.034371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,1,9]]},"published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1136\/jcp.2005.034371"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2005.034371","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}