{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:35:30Z","timestamp":1773203730823,"version":"3.50.1"},"reference-count":81,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Acid secretion is intimately associated with most upper gastrointestinal diseases.\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection is a major environmental factor modifying acid secretion.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    To study the association between the pattern of\n                    <jats:italic>H pylori<\/jats:italic>\n                    gastritis and gastric secretory function in a large number of subjects without specific upper gastrointestinal disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods and materials:<\/jats:bold>\n                    Maximal acid output (MAO) was measured in 255 patients with dyspepsia showing normal endoscopy. Activity and severity of gastritis, atrophy and\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection were assessed in body and antral biopsies. The correlations of histological parameters as well as age, sex, height, weight, smoking, serum gastrin, pepsinogen I and II, and their ratio with MAO were determined. Multiple linear regression was used to show the best possible predictors of MAO.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Negative relationships: Body atrophy and body-combined (active and chronic) inflammatory scores showed a potent inverse correlation with MAO (correlation coefficients (CC) 0.59 and 0.50, respectively). Body:antral chronic gastritis ratio and body:antral combined inflammation ratio (both with CC\u200a=\u200a0.49) and age (CC\u200a=\u200a0.44) were also inversely correlated with MAO. Intestinal metaplasia at both antral and body sites had negative relationships with acid output with CC\u200a=\u200a0.23 and 0.20, respectively. Positive relationships: Serum pepsinogen I, body\n                    <jats:italic>H pylori<\/jats:italic>\n                    density:combined inflammation ratio and pepsinogen I:II ratio with CC of 0.38, 0.38 and 0.30, respectively, correlated with MAO. The\n                    <jats:italic>H pylori<\/jats:italic>\n                    density: combined inflammation of both antrum and body positively correlated with MAO (CC\u200a=\u200a0.29 and 0.38, respectively). Male sex and patient height also positively correlated with acid output. Modelling showed that body combined inflammatory score, body atrophy, age and serum pepsinogen I are independent predictors of acid output (R\n                    <jats:sup>2<\/jats:sup>\n                    \u200a=\u200a0.62).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Combination of body gastritis, body atrophy, age and serum pepsinogen I can be used as predictors of acid-secretory state in populations infected with\n                    <jats:italic>H pylori<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1136\/jcp.2005.036111","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T20:38:59Z","timestamp":1146170339000},"page":"1293-1299","source":"Crossref","is-referenced-by-count":59,"title":["Gastric histology, serological markers and age as predictors of gastric acid secretion in patients infected with\n                    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