{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:38:55Z","timestamp":1791113935482,"version":"4.1.0"},"reference-count":32,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p>\n                  <jats:bold>Background:<\/jats:bold> Peutz\u2013Jeghers syndrome (PJS) is an autosomal dominant hamartomatous polyposis syndrome of the gastrointestinal tract, caused by a germline <jats:italic>STK11\/LKB1<\/jats:italic> mutation. Nasal polyposis was described in the original report by Peutz. Recently, a molecular\u2013genetic association between nasal polyposis and PJS has been reported.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Objective:<\/jats:bold> To further explore the occurrence and pathogenesis of PJS-related nasal polyposis.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> 51 patients with PJS, 84 unaffected family members and 36 spouses from 18 families with PJS were questioned for the presence of nasal polyposis. 12 PJS-related nasal polyps, 1 carcinoma of the nasal cavity and 28 sporadic nasal polyps were analysed for loss of (wild type) <jats:italic>STK11\/LKB1<\/jats:italic>, eosinophilia, squamous metaplasia, dysplasia and expression of cyclo-oxygenase 2 and p53.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Nasal polyps occurred in 8 of 51 patients with PJS, and were not reported by non-affected family members (p&lt;0.001). Germline <jats:italic>STK11\/LKB1<\/jats:italic> mutations were identified in all patients with PJS and nasal polyposis. Loss of heterozygosity was found in four of eight PJS-related nasal polyps, but not in sporadic nasal polyps (p\u200a=\u200a0.002). PJS-related nasal polyps showed less eosinophilia than sporadic nasal polyps (p&lt;0.001). Expression of cyclo-oxygenase 2 was found in 11 of 12 PJS-related nasal polyps and 19 of 28 sporadic nasal polyps (p&gt;0.05). Overexpression of p53 was not found.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> Nasal polyposis occurs in a significant number of Dutch patients with PJS, one of whom developed a carcinoma in the nasal cavity. The loss of heterozygosity, and the absence of eosinophilia suggest a distinct pathogenesis compared with sporadic nasal polyposis.<\/jats:p>","DOI":"10.1136\/jcp.2005.036418","type":"journal-article","created":{"date-parts":[[2006,6,14]],"date-time":"2006-06-14T21:00:52Z","timestamp":1150318852000},"page":"392-396","source":"Crossref","is-referenced-by-count":21,"title":["Nasal polyposis in Peutz\u2013Jeghers syndrome: a distinct histopathological and molecular genetic entity"],"prefix":"10.1136","volume":"60","author":[{"given":"Wendy W J","family":"de Leng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie","family":"Westerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian A J","family":"Weterman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marnix","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"van Dekken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis M","family":"Giardiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix W M","family":"de Rooij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H","family":"Paul Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G Johan A","family":"Offerhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josbert J","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2006,6,14]]},"reference":[{"key":"2025092504130954000_60.4.392.1","first-page":"134","volume":"10","year":"1921","journal-title":"Ned Maandschr v Geneesk"},{"key":"2025092504130954000_60.4.392.2","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1056\/NEJM194912292412601","volume":"241","year":"1949","journal-title":"N Engl J Med"},{"key":"2025092504130954000_60.4.392.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198706113162404"},{"key":"2025092504130954000_60.4.392.4","doi-asserted-by":"crossref","first-page":"896","DOI":"10.7326\/0003-4819-128-11-199806010-00004","volume":"128","year":"1998","journal-title":"Ann Intern Med"},{"key":"2025092504130954000_60.4.392.5","doi-asserted-by":"publisher","DOI":"10.1136\/gut.30.11.1588"},{"key":"2025092504130954000_60.4.392.6","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.03.014"},{"key":"2025092504130954000_60.4.392.7","doi-asserted-by":"publisher","DOI":"10.1038\/34432"},{"key":"2025092504130954000_60.4.392.8","doi-asserted-by":"publisher","DOI":"10.1038\/ng0198-38"},{"key":"2025092504130954000_60.4.392.9","first-page":"5267","volume":"58","year":"1998","journal-title":"Cancer Res"},{"key":"2025092504130954000_60.4.392.10","first-page":"6311","volume":"60","year":"2000","journal-title":"Cancer Res"},{"key":"2025092504130954000_60.4.392.11","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.2.126"},{"key":"2025092504130954000_60.4.392.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08018-0"},{"key":"2025092504130954000_60.4.392.13","first-page":"1330","volume":"90","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"2025092504130954000_60.4.392.14","first-page":"545","volume":"56","year":"1971","journal-title":"Am J Gastroenterol"},{"key":"2025092504130954000_60.4.392.15","first-page":"333","volume":"13","year":"1993","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"2025092504130954000_60.4.392.16","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1055\/s-0029-1226613","volume":"93","year":"1960","journal-title":"Fortschr Geb Rontgenstralen"},{"key":"2025092504130954000_60.4.392.17","first-page":"1435","volume":"25","year":"1969","journal-title":"Med Welt"},{"key":"2025092504130954000_60.4.392.18","doi-asserted-by":"publisher","DOI":"10.1007\/s003840050245"},{"key":"2025092504130954000_60.4.392.19","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601030"},{"key":"2025092504130954000_60.4.392.20","first-page":"855","volume":"136","year":"2002","journal-title":"Ann Intern Med"},{"key":"2025092504130954000_60.4.392.21","doi-asserted-by":"publisher","DOI":"10.1080\/00016480252814199"},{"key":"2025092504130954000_60.4.392.22","unstructured":"Drake-Lee AB. 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