{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T01:57:50Z","timestamp":1775267870702,"version":"3.50.1"},"reference-count":43,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p>\n                  <jats:bold>Aim:<\/jats:bold> To assess the biological significance of vascular endothelial growth factor (VEGF) A, VEGF receptor (Flk-1) and cyclooxygenase 2 (COX2) expression with respect to microvessel density (MVD), proliferative activity (Ki-67), expression of p53 and clinical presentation in a large cohort of nodal B cell lymphomas.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> An immunohistochemical and morphometric study was performed on a validated tissue microarray containing 271 B cell lymphoma specimens, 197 of which included follow-up data. Statistical assessment was done by Pearson\u2019s \u03c7<jats:sup>2<\/jats:sup> test, Spearman\u2019s rank correlation coefficient, analysis of variance and survival analysis.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> 266 (98%) cases were evaluable. Strong VEGF expression was observed in only 20 diffuse large B cell lymphomas (DLBCLs). Flk-1 and COX2 were expressed in 53 and 21 cases, respectively, mainly in DLBCLs, follicular lymphoma (FL) grade 3 and mantle cell lymphomas (MCLs), in a low proportion of cells. MVD decreased in the following order: DLBCLs, FLs, MCLs and small lymphocytic lymphomas\/chronic lymphocytic leukaemia (SLL\/CLLs). VEGF expression correlated with Ki-67, p53 and COX2 expression in the whole cohort and in DLBCLs. Flk-1 expression correlated with Ki-67 in the cohort and in SLL\/CLL and FL grade 1 and 2. COX2 expression correlated with Ki-67 and p53. The analysed angiogenesis parameters did not correlate with clinical parameters or survival.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> Angiogenesis plays a differential role in various B cell lymphomas. Aggressive lymphomas express the potential molecular therapeutic targets VEGF and COX2, and have higher MVD. In a few low proliferation-fraction lymphomas, Flk-1 might have a role in proliferative advantage. Therapeutic strategies aimed at angiogenesis should take into account lymphoma heterogeneity.<\/jats:p>","DOI":"10.1136\/jcp.2006.038661","type":"journal-article","created":{"date-parts":[[2006,6,21]],"date-time":"2006-06-21T21:07:14Z","timestamp":1150924034000},"page":"476-482","source":"Crossref","is-referenced-by-count":48,"title":["Angiogenesis in nodal B cell lymphomas: a high throughput 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