{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:16:10Z","timestamp":1785683770144,"version":"3.56.0"},"reference-count":18,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Friend leukaemia integration-1 (FLI-1) antibody is a useful marker for Ewing\u2019s sarcoma\/primitive neuroectodermal tumour (EWS\/PNET) and vascular tumours. However, it is also expressed in subsets of lymphoblastic lymphoma, Merkel cell carcinoma (MCC) and desmoplastic small round cell tumour (DSRCT).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    To determine expression of FLI-1 in various benign and malignant neoplasms, by immunohistochemical analysis on 4323 tumours using multiple tumour microarrays, as well as on whole sections.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    FLI-1 was expressed in 46\/62 EWS\/PNETs, 2\/3 olfactory neuroblastomas, 7\/102 small cell carcinomas of the lung, 10\/34 MCCs, 1\/14 rhabdomyosarcoma, 19\/132 non-Hodgkin\u2019s lymphomas, 2\/3 DSRCTs, and in 53\/74 benign and malignant vascular tumours. In addition, 27\/508 squamous cell carcinomas, 19\/837 adenocarcinomas, 10\/400 urothelial bladder cancers, 1\/40 basal cell carcinomas, 3\/29 liposarcomas, 1\/40 glioblastoma multiforme and 9\/29 medullar carcinomas of the breast expressed FLI-1. The sensitivity and specificity of FLI-1 to distinguish EWS\/PNET from all types of malignancies were 74.2% and 96.0%, respectively. Finally, the sensitivity and specificity of FLI-1 to distinguish EWS\/PNET from other small round cell tumours (SRCTs) were 74.2% and 91.6%, respectively.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    This study was the first to show that FLI-1 can be seen in a variety of solid tumours, some of which had never been explored before. This finding should be kept in mind, especially when using FLI-1 as a marker for finding the primary origin of poorly differentiated metastatic tumour. Finally, despite the expression of FLI-1 in numerous malignancies, it is still considered to be highly sensitive and specific in distinguishing EWS\/PNET from other tumour types in general and from other SRCTs in particular.\n                  <\/jats:p>","DOI":"10.1136\/jcp.2006.039230","type":"journal-article","created":{"date-parts":[[2006,8,17]],"date-time":"2006-08-17T21:03:36Z","timestamp":1155848616000},"page":"694-700","source":"Crossref","is-referenced-by-count":73,"title":["Friend leukaemia integration-1 expression in malignant and benign tumours: a multiple tumour tissue microarray analysis using polyclonal antibody"],"prefix":"10.1136","volume":"60","author":[{"given":"Paulette","family":"Mhawech-Fauceglia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois R","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiam","family":"Bshara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunle","family":"Odunsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Terracciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Sauter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard T","family":"Cheney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Groth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remedios","family":"Penetrante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulette","family":"Mhawech-Fauceglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2006,8,17]]},"reference":[{"key":"2025120518092514000_60.6.694.1","first-page":"216","volume":"17","year":"2000","journal-title":"Semin Diagn Pathol"},{"key":"2025120518092514000_60.6.694.2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204598"},{"key":"2025120518092514000_60.6.694.3","doi-asserted-by":"publisher","DOI":"10.1097\/00022744-200109000-00010"},{"key":"2025120518092514000_60.6.694.4","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1097\/00000478-200012000-00010","volume":"24","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"2025120518092514000_60.6.694.5","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200108000-00011"},{"key":"2025120518092514000_60.6.694.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02158.x"},{"key":"2025120518092514000_60.6.694.7","doi-asserted-by":"publisher","DOI":"10.1053\/S0046-8177(03)00339-3"},{"key":"2025120518092514000_60.6.694.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2003.08.026"},{"key":"2025120518092514000_60.6.694.9","doi-asserted-by":"publisher","DOI":"10.1309\/KC09-YTF2-M4DL-UYQ6"},{"key":"2025120518092514000_60.6.694.10","doi-asserted-by":"publisher","DOI":"10.1038\/nm0798-844"},{"key":"2025120518092514000_60.6.694.11","doi-asserted-by":"publisher","DOI":"10.1080\/13577149977839"},{"key":"2025120518092514000_60.6.694.12","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200203000-00005"},{"key":"2025120518092514000_60.6.694.13","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1097\/01.pas.0000167056.13614.62","volume":"29","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"2025120518092514000_60.6.694.14","first-page":"160","volume":"12","year":"2004","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"2025120518092514000_60.6.694.15","unstructured":"Fischer G, Odunsi K, Lele S, et al. Ovarian primary primitive neuroctodermal tumor (PNET) co-exisitng with endometrioid adenocarcinoma: a case report. Int J Gynecol Pathol (in press)."},{"key":"2025120518092514000_60.6.694.16","first-page":"561","volume":"42","year":"1998","journal-title":"Int J Dev Biol"},{"key":"2025120518092514000_60.6.694.17","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000159774.70288.7d"},{"key":"2025120518092514000_60.6.694.18","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800065"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2006.039230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T02:09:32Z","timestamp":1764986972000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2006.039230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,17]]},"references-count":18,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2007,6,8]]},"published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1136\/jcp.2006.039230"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2006.039230","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,17]]}}}