{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:30:42Z","timestamp":1789500642384,"version":"build-2803163510"},"reference-count":39,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    The role(s) of mast cells (MC) in gastric mucosal inflammation caused by\n                    <jats:italic>Helicobacter<\/jats:italic>\n                    <jats:italic>pylori<\/jats:italic>\n                    is (are) still debated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    To determine whether there is an association between MC density and epithelial cell apoptosis in antral gastric mucosa infected by\n                    <jats:italic>H pylori<\/jats:italic>\n                    .\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients and methods:<\/jats:bold>\n                    Biopsy specimens from 122\n                    <jats:italic>H pylori<\/jats:italic>\n                    -positive subjects with chronic active gastritis, 84 patients with non-steroidal anti-inflammatory drug-induced gastritis and 48 volunteers were included.\n                    <jats:italic>H pylori<\/jats:italic>\n                    genotypes were determined by PCR amplification of bacterial cultures. Immunohistochemical analysis was performed on tissue microarrays with anti-CD117, anti-chymase, anti-tryptase, anti-myeloperoxidase, anti-Bcl-2, anti-Bcl-x, anti-Bax and anti-caspase 3 antibodies.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Of the 122 patients infected with\n                    <jats:italic>H pylori<\/jats:italic>\n                    , 76 (62.3%) harboured\n                    <jats:italic>cagA<\/jats:italic>\n                    positive strains.\n                    <jats:italic>H pylori<\/jats:italic>\n                    isolates belonged to the\n                    <jats:italic>vacAs1\/m1<\/jats:italic>\n                    genotype in 82 (67%) cases, to the\n                    <jats:italic>vacAs2\/m2<\/jats:italic>\n                    genotype in 23 (18.8%) cases and to the\n                    <jats:italic>vacAs1\/m2<\/jats:italic>\n                    genotype in 17 (13.9%) cases. 61 (50%)\n                    <jats:italic>H pylori<\/jats:italic>\n                    isolates were\n                    <jats:italic>babA2<\/jats:italic>\n                    +. In patients infected with\n                    <jats:italic>H pylori<\/jats:italic>\n                    , the density of MC, and in particular the number of MC-associated epithelial cells, was correlated with a high number of apoptotic epithelial cells. Moreover, the density of MC was correlated with the number of neutrophils infiltrating the antral gastric mucosa, and was strongly increased in patients infected with\n                    <jats:italic>cagA<\/jats:italic>\n                    ,\n                    <jats:italic>vacAs1\/m1<\/jats:italic>\n                    and\n                    <jats:italic>babA2<\/jats:italic>\n                    positive strains.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Taken together, these data show that the density of MC can be considered as a histopathological criterion of gastritis activity in patients infected with\n                    <jats:italic>H pylori<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1136\/jcp.2006.040741","type":"journal-article","created":{"date-parts":[[2007,6,8]],"date-time":"2007-06-08T13:24:48Z","timestamp":1181309088000},"page":"600-607","source":"Crossref","is-referenced-by-count":24,"title":["Involvement of mast cells in gastritis caused by\n                    <i>Helicobacter pylori<\/i>\n                    : a potential role in epithelial cell apoptosis"],"prefix":"10.1136","volume":"60","author":[{"given":"V\u00e9ronique","family":"Hofman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Lassalle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Selva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kheira","family":"Kalem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Steff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"H\u00e9buterne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Sicard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Auberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Hofman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2007,6,8]]},"reference":[{"key":"2025121322034730000_60.6.600.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2005.09.012"},{"key":"2025121322034730000_60.6.600.2","doi-asserted-by":"publisher","DOI":"10.1038\/381077a0"},{"key":"2025121322034730000_60.6.600.3","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2001.790102.x"},{"key":"2025121322034730000_60.6.600.4","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2000.917305.x"},{"key":"2025121322034730000_60.6.600.5","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200203)32:3<671::AID-IMMU671>3.3.CO;2-X"},{"key":"2025121322034730000_60.6.600.6","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.6.2603"},{"key":"2025121322034730000_60.6.600.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70167-7"},{"key":"2025121322034730000_60.6.600.8","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"2025121322034730000_60.6.600.9","doi-asserted-by":"publisher","DOI":"10.1038\/ncponc0046"},{"key":"2025121322034730000_60.6.600.10","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/labinvest.3780347","volume":"81","year":"2001","journal-title":"Lab Invest"},{"key":"2025121322034730000_60.6.600.11","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0002-9440(10)64399-4","volume":"161","year":"2002","journal-title":"Am J Pathol"},{"key":"2025121322034730000_60.6.600.12","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1128\/JCM.36.10.3048-3050.1998","volume":"36","year":"1998","journal-title":"J Clin Microbiol"},{"key":"2025121322034730000_60.6.600.13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.22.12778"},{"key":"2025121322034730000_60.6.600.14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03685.x"},{"key":"2025121322034730000_60.6.600.15","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.6.804"},{"key":"2025121322034730000_60.6.600.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2004.12.008"},{"key":"2025121322034730000_60.6.600.17","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1136\/jcp.52.3.210","volume":"52","year":"1999","journal-title":"J Clin Pathol"},{"key":"2025121322034730000_60.6.600.18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2003.01731.x"},{"key":"2025121322034730000_60.6.600.19","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/jlb.67.6.841","volume":"67","year":"2000","journal-title":"J Leukoc Biol"},{"key":"2025121322034730000_60.6.600.20","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/jlb.67.4.585","volume":"67","year":"2000","journal-title":"J Leukoc Biol"},{"key":"2025121322034730000_60.6.600.21","doi-asserted-by":"publisher","DOI":"10.1159\/000237039"},{"key":"2025121322034730000_60.6.600.22","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1136\/gut.43.2008.S27","volume":"43","year":"1998","journal-title":"Gut"},{"key":"2025121322034730000_60.6.600.23","first-page":"53","volume":"71","year":"1988","journal-title":"Yale J Biol Med"},{"key":"2025121322034730000_60.6.600.24","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1136\/gut.43.5.592","volume":"43","year":"1998","journal-title":"Gut"},{"key":"2025121322034730000_60.6.600.25","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0002-9270(00)02240-1","volume":"96","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"2025121322034730000_60.6.600.26","first-page":"951","volume":"63","year":"2003","journal-title":"Cancer Res"},{"key":"2025121322034730000_60.6.600.27","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.032144"},{"key":"2025121322034730000_60.6.600.28","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1152\/ajpgi.00502.2002","volume":"285","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2025121322034730000_60.6.600.29","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.8.5001-5009.2001"},{"key":"2025121322034730000_60.6.600.30","first-page":"6124","volume":"59","year":"1999","journal-title":"Cancer Res"},{"key":"2025121322034730000_60.6.600.31","doi-asserted-by":"publisher","DOI":"10.1086\/379629"},{"key":"2025121322034730000_60.6.600.32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1083-4389.2004.00246.x"},{"key":"2025121322034730000_60.6.600.33","first-page":"1479","volume":"14","year":"2000","journal-title":"J Cell Biol"},{"key":"2025121322034730000_60.6.600.34","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0699fje"},{"key":"2025121322034730000_60.6.600.35","first-page":"1019","volume":"10","year":"2003","journal-title":"Oncol Rep"},{"key":"2025121322034730000_60.6.600.36","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.13.1443"},{"key":"2025121322034730000_60.6.600.37","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10235"},{"key":"2025121322034730000_60.6.600.38","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000051405.68811.4D"},{"key":"2025121322034730000_60.6.600.39","first-page":"319","volume":"77","year":"1997","journal-title":"Lab Invest"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2006.040741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T06:03:57Z","timestamp":1765692237000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2006.040741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":39,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2007,6,8]]},"published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1136\/jcp.2006.040741"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2006.040741","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}