{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:01:52Z","timestamp":1770822112758,"version":"3.50.1"},"reference-count":30,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:sec>\n                  <jats:title>Aims:<\/jats:title>\n                  <jats:p>Cervical screening, currently performed by cervical cytology, depends on the timely detection of malignant lesions for its success. The presence of high-risk human papillomavirus (hrHPV) is associated with an increased risk of subsequent high-grade cervical intra-epithelial neoplasia (CIN2\/3) and cervical cancer. The aim of this study was to determine the extent to which hrHPV is present in cervical smears with a high a priori chance of being false negative (ie, in normal smears preceding CIN2\/3).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>Archival specimens of 187 women with CIN2\/3 and preceding normal conventional smears were identified retrospectively. Of these specimens, 144 (77%) had adequate cytological samples for further HPV DNA testing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Of 144 CIN2\/3 lesions, preceding normal smears showed hrHPV positivity in 80% of cases. Of the hrHPV-positive smears, 69% were upgraded cytologically at rescreening compared with 24% of hrHPV-negative smears (p&lt;0.001). Upgrading of smears was not associated with specific hrHPV types (p\u200a=\u200a0.217). In over 90% of cases, type concordance in smear and CIN2\/3 lesion was demonstrated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>hrHPV is present in a high proportion of normal archival smears preceding CIN2\/3, and false-negative cytology was highly associated with the presence of hrHPV. This supports the current notion that hrHPV testing can be used as a primary cervical screening tool. If so, hrHPV-positive cervical smears should be carefully examined for cytological abnormalities to reduce false-negative cervical cytology.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jcp.2006.045948","type":"journal-article","created":{"date-parts":[[2007,8,3]],"date-time":"2007-08-03T21:28:43Z","timestamp":1186176523000},"page":"385-389","source":"Crossref","is-referenced-by-count":11,"title":["High-risk human papillomavirus is present in cytologically false-negative smears: an analysis of \u201cnormal\u201d smears preceding CIN2\/3"],"prefix":"10.1136","volume":"61","author":[{"given":"S","family":"Bulk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Rozendaal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G D","family":"Zielinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Berkhof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N C Fransen","family":"Daalmeijer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J F","family":"Snijders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F J","family":"van Kemenade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C J L M","family":"Meijer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2007,8,3]]},"reference":[{"key":"2025092503304902000_61.3.385.1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"2025092503304902000_61.3.385.2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21955"},{"key":"2025092503304902000_61.3.385.3","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20076"},{"key":"2025092503304902000_61.3.385.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67069-9"},{"key":"2025092503304902000_61.3.385.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14955-0"},{"key":"2025092503304902000_61.3.385.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2004.00227.x"},{"key":"2025092503304902000_61.3.385.7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603210"},{"key":"2025092503304902000_61.3.385.8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39196.740995.BE"},{"key":"2025092503304902000_61.3.385.9","first-page":"6027","article-title":"A prospective study showing long-term infection with human papillomavirus 16 before the development of cervical carcinoma in situ.","volume":"60","author":"Ylitalo","year":"2000","journal-title":"Cancer Res"},{"key":"2025092503304902000_61.3.385.10","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.1926"},{"key":"2025092503304902000_61.3.385.11","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf013"},{"key":"2025092503304902000_61.3.385.12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911253412201"},{"key":"2025092503304902000_61.3.385.13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.11.1500"},{"key":"2025092503304902000_61.3.385.14","doi-asserted-by":"crossref","unstructured":"van Ballegooijen M Hermens R . 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