{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:37:26Z","timestamp":1792658246598,"version":"4.5.0"},"reference-count":19,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:sec>\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>Ascending aortic aneurysms (AA) are a common, though poorly understood medical condition.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aims:<\/jats:title>\n                  <jats:p>To document the histological changes in a large series of human ascending AA, and to correlate these changes with clinical variables.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>111 ascending AA were excised at surgery over a 3 year period. Each aneurysm was received as a continuous ring of tissue. Sections were taken from the anterior, posterior, greater and lesser curvature of the aorta and graded in a semi-quantitative fashion for the degree of elastin fragmentation, elastin loss, smooth muscle cell (SMC) loss, intimal changes and inflammation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Mean patient age at surgery was 58.7 (15.6) years; there were 70 men and 41 women. 12 patients had Marfan syndrome, 34 (30.6%) had a bicuspid aortic valve (BAV), while 71 (64.0%) had a tricuspid aortic valve (TAV). Inflammatory cells were present in 28 cases (25.2%) and were confined to the adventitia. No particular region of the aortic circumference was more severely affected, however a BAV was associated with significantly less intimal change, and less fragmentation and loss of elastic tissue compared with patients with a TAV. Advanced age (&gt;65 years), female gender and Marfan syndrome were all associated with more severe elastin degeneration and smooth muscle cell loss (p&lt;0.05 for all).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>Results indicate a wide variation in the histological appearance in ascending AA, depending on patient characteristics. They suggest that the underlying aneurysm pathogenesis may also be highly variable; this warrants further investigation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jcp.2006.046250","type":"journal-article","created":{"date-parts":[[2007,10,15]],"date-time":"2007-10-15T20:33:29Z","timestamp":1192480409000},"page":"519-523","source":"Crossref","is-referenced-by-count":67,"title":["Variation in the histopathological features of patients with ascending aortic aneurysms: a study of 111 surgically excised cases"],"prefix":"10.1136","volume":"61","author":[{"given":"M J","family":"Collins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Dev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B H","family":"Strauss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P W M","family":"Fedak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Butany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2007,10,15]]},"reference":[{"key":"2025092505381575000_61.4.519.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66459-8"},{"key":"2025092505381575000_61.4.519.2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(95)00045-3"},{"key":"2025092505381575000_61.4.519.3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.10.1425"},{"key":"2025092505381575000_61.4.519.4","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/00001573-199609000-00010","article-title":"Basic science of abdominal aortic aneurysms: emerging therapeutic strategies for an unresolved clinical problem.","volume":"11","author":"Thompson","year":"1996","journal-title":"Curr Opin Cardiol"},{"key":"2025092505381575000_61.4.519.5","doi-asserted-by":"publisher","DOI":"10.1097\/00001573-200211000-00015"},{"key":"2025092505381575000_61.4.519.6","unstructured":"Collins MJ Butany J Fedak PWM . Ascending aortic aneurysm pathogenesis from a molecular perspective. Cardiovacular Pathology. In press."},{"key":"2025092505381575000_61.4.519.7","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2002.121124"},{"key":"2025092505381575000_61.4.519.8","doi-asserted-by":"publisher","DOI":"10.1185\/030079904125003143"},{"key":"2025092505381575000_61.4.519.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2004.06.007"},{"key":"2025092505381575000_61.4.519.10","first-page":"54","article-title":"Histopathological grading of ascending aortic aneurysm: comparison of patients with bicuspid versus tricuspid aortic valve.","volume":"12","author":"Matthias Bechtel","year":"2003","journal-title":"J Heart Valve Dis"},{"key":"2025092505381575000_61.4.519.11","doi-asserted-by":"crossref","first-page":"II268","DOI":"10.1161\/01.CIR.0000138384.68947.20","article-title":"Effects of deletion of the tissue inhibitor of matrix metalloproteinases-1 gene on the progression of murine thoracic aortic aneurysms.","volume":"110","author":"Ikonomidis","year":"2004","journal-title":"Circulation"},{"key":"2025092505381575000_61.4.519.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(02)73576-9"},{"key":"2025092505381575000_61.4.519.13","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118037"},{"key":"2025092505381575000_61.4.519.14","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8931"},{"key":"2025092505381575000_61.4.519.15","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2003.163"},{"key":"2025092505381575000_61.4.519.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2004.07.009"},{"key":"2025092505381575000_61.4.519.17","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.3.2.295"},{"key":"2025092505381575000_61.4.519.18","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(03)00398-2"},{"key":"2025092505381575000_61.4.519.19","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00372-0"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2006.046250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:38:23Z","timestamp":1758803903000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2006.046250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,15]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,3,28]]},"published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1136\/jcp.2006.046250"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2006.046250","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,15]]}}}