{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:40:34Z","timestamp":1792294834455,"version":"4.4.0"},"reference-count":133,"publisher":"Oxford University Press (OUP)","issue":"993","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Burkitt lymphoma (BL) is an aggressive B-cell malignancy with endemic, sporadic and immunodeficiency-associated variants. It has been known for many years that the fundamental transforming event in BL is the translocation of the MYC gene, and the events that bring about this translocation and those that allow cells to survive with the constitutive expression of MYC have been the subject of intense investigation. Epstein\u2013Barr virus (EBV) infection, malaria, immunodeficiency and spontaneous, somatic mutation can all contribute to the origin and maintenance of this cancer and their mechanisms are the subject of this review.<\/jats:p>","DOI":"10.1136\/jcp.2007.047977","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T18:23:11Z","timestamp":1196187791000},"page":"372-377","source":"Crossref","is-referenced-by-count":98,"title":["Epstein\u2013Barr virus and Burkitt lymphoma"],"prefix":"10.1093","volume":"84","author":[{"given":"G","family":"Brady","sequence":"first","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Imperial College , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G J","family":"MacArthur","sequence":"additional","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Imperial College , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P J","family":"Farrell","sequence":"additional","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Imperial College , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,8,20]]},"reference":[{"key":"2023041909445810000_bib1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1634\/theoncologist.11-4-375","article-title":"Burkitt's lymphoma: clinicopathologic features and differential diagnosis","volume":"11","author":"Ferry","year":"2006","journal-title":"Oncologist"},{"key":"2023041909445810000_bib2","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1517\/14712598.6.11.1193","article-title":"The role of Epstein\u2013Barr virus in cancer","volume":"6","author":"Pattle","year":"2006","journal-title":"Expert Opin Biol Ther"},{"key":"2023041909445810000_bib3","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/S1470-2045(04)01650-X","article-title":"Is endemic Burkitt's lymphoma an alliance between three infections and a tumour promoter?","volume":"5","author":"van den Bosch","year":"2004","journal-title":"Lancet Oncol"},{"key":"2023041909445810000_bib4","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1182\/blood-2004-02-0405","article-title":"Adult Burkitt leukemia and lymphoma","volume":"104","author":"Blum","year":"2004","journal-title":"Blood"},{"key":"2023041909445810000_bib5","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1002\/1097-0142(19951001)76:7<1245::AID-CNCR2820760723>3.0.CO;2-D","article-title":"The investigation of Epstein\u2013Barr viral sequences in 41 cases of Burkitt's lymphoma from Egypt: epidemiologic correlations","volume":"76","author":"Anwar","year":"1995","journal-title":"Cancer"},{"key":"2023041909445810000_bib6","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/(SICI)1096-9896(199902)187:3<326::AID-PATH242>3.0.CO;2-N","article-title":"Frequent expansion of Epstein\u2013Barr virus (EBV) infected cells in germinal centres of tonsils from an area with a high incidence of EBV-associated lymphoma","volume":"187","author":"Araujo","year":"1999","journal-title":"J Pathol"},{"key":"2023041909445810000_bib7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/ijc.11443","article-title":"Geographic variation in Epstein\u2013Barr virus-associated Burkitt's lymphoma in children from Brazil","volume":"108","author":"Klumb","year":"2004","journal-title":"Int J Cancer"},{"key":"2023041909445810000_bib8","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nrmicro1089","article-title":"Endemic Burkitt's lymphoma: a polymicrobial disease?","volume":"3","author":"Rochford","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"2023041909445810000_bib9","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1136\/sti.76.5.335","article-title":"AIDS related systemic non-Hodgkin's lymphoma","volume":"76","author":"Powles","year":"2000","journal-title":"Sex Transm Infect"},{"key":"2023041909445810000_bib10","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1002\/1097-0142(19840415)53:8<1777::AID-CNCR2820530828>3.0.CO;2-7","article-title":"Jaw involvement in American Burkitt's Lymphoma","volume":"53","author":"Sariban","year":"1984","journal-title":"Cancer"},{"key":"2023041909445810000_bib11"},{"key":"2023041909445810000_bib12","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0014-2964(72)90025-4","article-title":"Cell kinetics of African cases of Burkitt lymphoma. 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