{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:01:14Z","timestamp":1791277274309,"version":"4.1.0"},"reference-count":101,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p>Sitosterolaemia is an extremely rare autosomal recessive disease, the key feature of which is the impairment of pathways that normally prevent absorption and retention of non-cholesterol sterols, for example plant sterols and shellfish sterols. The clinical manifestations are akin to familial hypercholesterolaemia (such as presence of tendon xanthomas and premature atherosclerosis), but with \u201cnormal to moderately elevated\u201d cholesterol levels. The gene(s) causing sitosterolaemia was mapped to the STSL locus on human chromosome 2p21, and mutations in either of the two genes that comprise this locus, ABCG5 or ABCG8, cause this disease. Exact prevalence is unknown, but there are estimated to be 80\u2013100 cases around the world. This rare disease has shed light into the molecular mechanisms that control sterol trafficking in the enterocyte and hepatocyte; ABCG5 and ABCG8 heterodimerise to form a sterol efflux transporter in the liver and intestine. In this review the pathophysiology, clinical manifestations and approach to clinical and laboratory diagnosis of this disease are described.<\/jats:p>","DOI":"10.1136\/jcp.2007.049775","type":"journal-article","created":{"date-parts":[[2008,4,25]],"date-time":"2008-04-25T13:25:50Z","timestamp":1209129950000},"page":"588-594","source":"Crossref","is-referenced-by-count":101,"title":["Sitosterolaemia: pathophysiology, clinical presentation and laboratory diagnosis"],"prefix":"10.1136","volume":"61","author":[{"given":"S","family":"Kidambi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S B","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2008,4,25]]},"reference":[{"key":"2025121404305015000_61.5.588.1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107640"},{"key":"2025121404305015000_61.5.588.2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1527-3466.2002.tb00096.x","article-title":"Sitosterolemia.","volume":"20","author":"Salen","year":"2002","journal-title":"Cardiovasc Drug Rev"},{"key":"2025121404305015000_61.5.588.3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112513"},{"key":"2025121404305015000_61.5.588.4","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5497.1771"},{"key":"2025121404305015000_61.5.588.5","doi-asserted-by":"publisher","DOI":"10.1086\/321294"},{"key":"2025121404305015000_61.5.588.6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/83799","article-title":"Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption.","volume":"27","author":"Lee","year":"2001","journal-title":"Nat Genet"},{"key":"2025121404305015000_61.5.588.7","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(95)00263-6"},{"key":"2025121404305015000_61.5.588.8","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-006-1000-5"},{"key":"2025121404305015000_61.5.588.9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0002-8223(21)05668-6","article-title":"Sterol content of foods of plant origin.","volume":"73","author":"Weihrauch","year":"1978","journal-title":"J Am Diet Assoc"},{"key":"2025121404305015000_61.5.588.10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/oxfordjournals.aje.a115479","article-title":"Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population.","volume":"131","author":"Miettinen","year":"1990","journal-title":"Am J Epidemiol"},{"key":"2025121404305015000_61.5.588.11","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/ajcn\/74.1.141","article-title":"Plant sterol intakes and colorectal cancer risk in the Netherlands Cohort Study on Diet and Cancer.","volume":"74","author":"Normen","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"2025121404305015000_61.5.588.12","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0022-2275(20)33370-8","article-title":"Percent cholesterol absorption in normal women and men quantified with dual stable isotopic tracers and negative ion mass spectrometry.","volume":"40","author":"Bosner","year":"1999","journal-title":"J Lipid Res"},{"key":"2025121404305015000_61.5.588.13","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(69)90078-X"},{"key":"2025121404305015000_61.5.588.14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1993.tb00737.x"},{"key":"2025121404305015000_61.5.588.15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106315"},{"key":"2025121404305015000_61.5.588.16","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1161\/01.ATV.12.5.563","article-title":"Increased sitosterol absorption is offset by rapid elimination to prevent accumulation in heterozygotes with sitosterolemia.","volume":"12","author":"Salen","year":"1992","journal-title":"Arterioscler Thromb"},{"key":"2025121404305015000_61.5.588.17","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0022-2275(20)41411-7","article-title":"Sitosterolemia.","volume":"33","author":"Salen","year":"1992","journal-title":"J Lipid Res"},{"key":"2025121404305015000_61.5.588.18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3109\/07853899708999333","article-title":"Phytosterolaemia: diagnosis, characterization and therapeutical approaches.","volume":"29","author":"Lutjohann","year":"1997","journal-title":"Ann Med"},{"key":"2025121404305015000_61.5.588.19","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(77)90180-0"},{"key":"2025121404305015000_61.5.588.20","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1093\/ajcn\/71.4.908","article-title":"Soy sterol esters and beta-sitostanol ester as inhibitors of cholesterol absorption in human small bowel.","volume":"71","author":"Normen","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"2025121404305015000_61.5.588.21","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601083"},{"key":"2025121404305015000_61.5.588.22","doi-asserted-by":"crossref","first-page":"15D","DOI":"10.1016\/j.amjcard.2005.03.015","article-title":"Plant stanol and sterol esters in the control of blood cholesterol levels: mechanism and safety aspects.","volume":"96","author":"Plat","year":"2005","journal-title":"Am J Cardiol"},{"key":"2025121404305015000_61.5.588.23","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/0005-2736(83)90243-2","article-title":"Some aspects of mechanism of inhibition of cholesterol absorption by beta-sitosterol.","volume":"732","author":"Ikeda","year":"1983","journal-title":"Biochim Biophys Acta"},{"key":"2025121404305015000_61.5.588.24","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/S0022-2275(20)38403-0","article-title":"Inhibition of cholesterol absorption in rats by plant sterols.","volume":"29","author":"Ikeda","year":"1988","journal-title":"J Lipid Res"},{"key":"2025121404305015000_61.5.588.25","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0005-2736(90)90268-S","article-title":"Soybean phosphatidylcholine vesicles containing plant sterols: a fluorescence anisotropy study.","volume":"1028","author":"Schuler","year":"1990","journal-title":"Biochim Biophys Acta"},{"key":"2025121404305015000_61.5.588.26","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.6.860"},{"key":"2025121404305015000_61.5.588.27","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0022-2275(20)42748-8","article-title":"Apparent lack of conversion of sitosterol into C24-bile acids in humans.","volume":"31","author":"Boberg","year":"1990","journal-title":"J Lipid Res"},{"key":"2025121404305015000_61.5.588.28","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0022-2275(20)40109-9","article-title":"Review of cholesterol absorption with emphasis on dietary and biliary cholesterol.","volume":"35","author":"Wilson","year":"1994","journal-title":"J Lipid Res"},{"key":"2025121404305015000_61.5.588.29","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3963"},{"key":"2025121404305015000_61.5.588.30","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200216000"},{"key":"2025121404305015000_61.5.588.31","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310223200"},{"key":"2025121404305015000_61.5.588.32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402634200"},{"key":"2025121404305015000_61.5.588.33","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0022-2275(20)31486-3","article-title":"Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8.","volume":"43","author":"Lu","year":"2002","journal-title":"J Lipid Res"},{"key":"2025121404305015000_61.5.588.34","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000143532.93729.d6"},{"key":"2025121404305015000_61.5.588.35","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M300522-JLR200"},{"key":"2025121404305015000_61.5.588.36","doi-asserted-by":"crossref","first-page":"395","DOI":"10.33549\/physiolres.930470","article-title":"Polymorphisms in ABCG5 and ABCG8 transporters and plasma cholesterol levels.","volume":"53","author":"Hubacek","year":"2004","journal-title":"Physiol Res"},{"key":"2025121404305015000_61.5.588.37","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M300278-JLR200"},{"key":"2025121404305015000_61.5.588.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2004.03.015"},{"key":"2025121404305015000_61.5.588.39","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M400210-JLR200"},{"key":"2025121404305015000_61.5.588.40","doi-asserted-by":"publisher","DOI":"10.1042\/CS20050030"},{"key":"2025121404305015000_61.5.588.41","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21847"},{"key":"2025121404305015000_61.5.588.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2007.06.004"},{"key":"2025121404305015000_61.5.588.43","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)01053-9"},{"key":"2025121404305015000_61.5.588.44","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-005-0006-2"},{"key":"2025121404305015000_61.5.588.45","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702236200"},{"key":"2025121404305015000_61.5.588.46","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-005-0040-7"},{"key":"2025121404305015000_61.5.588.47","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/humu.1206","article-title":"Mutations in ATP-cassette binding proteins G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia.","volume":"18","author":"Hubacek","year":"2001","journal-title":"Hum Mutat"},{"key":"2025121404305015000_61.5.588.48","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M500511-JLR200"},{"key":"2025121404305015000_61.5.588.49","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M400167-JLR200"},{"key":"2025121404305015000_61.5.588.50","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1172\/JCI105587","article-title":"Absorption of cholesterol from a micellar solution: intestinal perfusion studies in man.","volume":"46","author":"Simmonds","year":"1967","journal-title":"J Clin Invest"},{"key":"2025121404305015000_61.5.588.51","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.10.006"},{"key":"2025121404305015000_61.5.588.52","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-2-5"},{"key":"2025121404305015000_61.5.588.53","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20540"},{"key":"2025121404305015000_61.5.588.54","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M500115-JLR200"},{"key":"2025121404305015000_61.5.588.55","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411080200"},{"key":"2025121404305015000_61.5.588.56","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.252582399"},{"key":"2025121404305015000_61.5.588.57","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.10.074"},{"key":"2025121404305015000_61.5.588.58","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.10.022"},{"key":"2025121404305015000_61.5.588.59","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109927200"},{"key":"2025121404305015000_61.5.588.60","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01894-06"},{"key":"2025121404305015000_61.5.588.61","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093131"},{"key":"2025121404305015000_61.5.588.62","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405817200"},{"key":"2025121404305015000_61.5.588.63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0237205100"},{"key":"2025121404305015000_61.5.588.64","doi-asserted-by":"publisher","DOI":"10.2174\/1568008054064887"},{"key":"2025121404305015000_61.5.588.65","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R300008-JLR200"},{"key":"2025121404305015000_61.5.588.66","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/S0022-2275(20)38259-6","article-title":"Increased sitosterol absorption, decreased removal, and expanded body pools compensate for reduced cholesterol synthesis in sitosterolemia with xanthomatosis.","volume":"30","author":"Salen","year":"1989","journal-title":"J Lipid Res"},{"key":"2025121404305015000_61.5.588.67","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/S0022-2275(20)41495-6","article-title":"Sterol absorption and sterol balance in phytosterolemia evaluated by deuterium-labeled sterols: effect of sitostanol treatment.","volume":"36","author":"Lutjohann","year":"1995","journal-title":"J Lipid Res"},{"key":"2025121404305015000_61.5.588.68","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1980.tb00006.x"},{"key":"2025121404305015000_61.5.588.69","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.02.027"},{"key":"2025121404305015000_61.5.588.70","first-page":"1392","article-title":"Clinical and molecular genetic analysis of a family with sitosterolemia and co-existing erythrocyte and platelet abnormalities.","volume":"91","author":"Su","year":"2006","journal-title":"Haematologica"},{"key":"2025121404305015000_61.5.588.71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05599.x"},{"key":"2025121404305015000_61.5.588.72","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/S0022-2275(20)34286-3","article-title":"Lethal atherosclerosis associated with abnormal plasma and tissue sterol composition in sitosterolemia with xanthomatosis.","volume":"26","author":"Salen","year":"1985","journal-title":"J Lipid Res"},{"key":"2025121404305015000_61.5.588.73","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1056\/NEJM197602262940907","article-title":"Beta-sitosterolemia and xanthomatosis.","volume":"294","author":"Shulman","year":"1976","journal-title":"N Engl J Med"},{"key":"2025121404305015000_61.5.588.74","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-004-0165-2"},{"key":"2025121404305015000_61.5.588.75","doi-asserted-by":"crossref","first-page":"591","DOI":"10.2169\/internalmedicine.42.591","article-title":"A 19-year-old man with myocardial infarction and sitosterolemia.","volume":"42","author":"Katayama","year":"2003","journal-title":"Intern Med"},{"key":"2025121404305015000_61.5.588.76","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/oxfordjournals.eurheartj.a014983","article-title":"Coronary bypass grafts in a young girl with sitosterolemia.","volume":"17","author":"Kolovou","year":"1996","journal-title":"Eur Heart J"},{"key":"2025121404305015000_61.5.588.77","first-page":"914","article-title":"Phytosterols in aortic tissue in adults and infants.","volume":"88","author":"Mellies","year":"1976","journal-title":"J Lab Clin Med"},{"key":"2025121404305015000_61.5.588.78","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000050545.21826.AD"},{"key":"2025121404305015000_61.5.588.79","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.10.032"},{"key":"2025121404305015000_61.5.588.80","doi-asserted-by":"publisher","DOI":"10.1301\/nr.2006.sept.385-402"},{"key":"2025121404305015000_61.5.588.81","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2005.04.001"},{"key":"2025121404305015000_61.5.588.82","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1161\/01.ATV.0000151984.34920.aa","article-title":"Plasma plant sterol levels: another coronary heart disease risk factor?","volume":"25","author":"Sehayek","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2025121404305015000_61.5.588.83","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000149140.00499.92"},{"key":"2025121404305015000_61.5.588.84","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M200455-JLR200"},{"key":"2025121404305015000_61.5.588.85","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2005.00472.x"},{"key":"2025121404305015000_61.5.588.86","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200628"},{"key":"2025121404305015000_61.5.588.87","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0022-2275(20)34390-X","article-title":"Increased plasma cholestanol and 5 alpha-saturated plant sterol derivatives in subjects with sitosterolemia and xanthomatosis.","volume":"26","author":"Salen","year":"1985","journal-title":"J Lipid Res"},{"key":"2025121404305015000_61.5.588.88","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/0005-2760(85)90141-9","article-title":"The presence of 5 alpha-sitostanol in the serum of a patient with phytosterolemia, and its biosynthesis from plant steroids in rats with bile fistula.","volume":"836","author":"Skrede","year":"1985","journal-title":"Biochim Biophys Acta"},{"key":"2025121404305015000_61.5.588.89","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3109\/00365519609088612","article-title":"Phytosterolaemia in a Norwegian family: diagnosis and characterization of the first Scandinavian case.","volume":"56","author":"Lutjohann","year":"1996","journal-title":"Scand J Clin Lab Invest"},{"key":"2025121404305015000_61.5.588.90","doi-asserted-by":"publisher","DOI":"10.1007\/BF02532363"},{"key":"2025121404305015000_61.5.588.91","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0022-2275(20)42787-7","article-title":"Increased plasma plant sterol levels in heterozygotes with sitosterolemia and xanthomatosis.","volume":"31","author":"Hidaka","year":"1990","journal-title":"J Lipid Res"},{"key":"2025121404305015000_61.5.588.92","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.11.859"},{"key":"2025121404305015000_61.5.588.93","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1194\/jlr.C400004-JLR200","article-title":"Rapid quantification of free and esterified phytosterols in human serum using APPI-LC-MS\/MS.","volume":"46","author":"Lembcke","year":"2005","journal-title":"J Lipid Res"},{"key":"2025121404305015000_61.5.588.94","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000116766.31036.03"},{"key":"2025121404305015000_61.5.588.95","first-page":"389","article-title":"A marked and sustained reduction in LDL sterols by diet and cholestyramine in beta-sitosterolemia.","volume":"18","author":"Parsons","year":"1995","journal-title":"Clin Invest Med"},{"key":"2025121404305015000_61.5.588.96","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/S0022-2275(20)41897-8","article-title":"Regulation of cholesterol biosynthesis in sitosterolemia: effects of lovastatin, cholestyramine, and dietary sterol restriction.","volume":"32","author":"Nguyen","year":"1991","journal-title":"J Lipid Res"},{"key":"2025121404305015000_61.5.588.97","first-page":"605","article-title":"Comparative effect of dietary sitosterol on plasma sterols and cholesterol and bile acid synthesis in a sitosterolemic homozygote and heterozygote subject.","volume":"16","author":"Cobb","year":"1997","journal-title":"J Am Coll Nutr"},{"key":"2025121404305015000_61.5.588.98","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-78-19002"},{"key":"2025121404305015000_61.5.588.99","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(86)90141-3"},{"key":"2025121404305015000_61.5.588.100","first-page":"13","article-title":"Prolonged reduction in human blood cholesterol levels induced by plant sterols.","volume":"21","author":"Lesesne","year":"1955","journal-title":"Med Bull (Ann Arbor)"},{"key":"2025121404305015000_61.5.588.101","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2007.049775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T12:31:05Z","timestamp":1765715465000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2007.049775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,25]]},"references-count":101,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2008,4,25]]},"published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1136\/jcp.2007.049775"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2007.049775","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,25]]}}}