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Because of their rarity, these infants usually present to clinicians who have little or no prior experience of these conditions, and therefore laboratory-based clinicians with knowledge of the key laboratory\/pathological abnormalities and clinical features have a valuable role in identifying the possibility of immunodeficiency. Secondary T cell deficiency is a cardinal feature of HIV infection and the specific susceptibility to infectious micro-organisms is highlighted. The possibility of T cell immunodeficiency should be considered in any patient presenting with unusual or severe viral, fungal or protozoal infection.<\/jats:p>","DOI":"10.1136\/jcp.2007.051144","type":"journal-article","created":{"date-parts":[[2008,8,28]],"date-time":"2008-08-28T13:24:56Z","timestamp":1219929896000},"page":"988-993","source":"Crossref","is-referenced-by-count":24,"title":["T cell immunodeficiency"],"prefix":"10.1136","volume":"61","author":[{"given":"J D M","family":"Edgar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2008,8,28]]},"reference":[{"key":"2025120521164770000_61.9.988.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03126.x"},{"key":"2025120521164770000_61.9.988.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03138.x"},{"key":"2025120521164770000_61.9.988.3","doi-asserted-by":"publisher","DOI":"10.1006\/clim.1999.4799"},{"key":"2025120521164770000_61.9.988.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.08.053"},{"key":"2025120521164770000_61.9.988.5","unstructured":"UK Primary Immunodeficiency Network. http:\/\/www.ukpin.org.uk (accessed 13 June 2008)."},{"key":"2025120521164770000_61.9.988.6","first-page":"883","article-title":"The European internet-based patient and research database for primary immunodeficiencies: results 2004\u00e2\u0080\u009306.","volume":"117","author":"Eades-Perner","year":"2006","journal-title":"Clin Immunol"},{"key":"2025120521164770000_61.9.988.7","doi-asserted-by":"publisher","DOI":"10.1038\/nri2195"},{"key":"2025120521164770000_61.9.988.8","doi-asserted-by":"publisher","DOI":"10.1136\/adc.70.4.260"},{"key":"2025120521164770000_61.9.988.9","doi-asserted-by":"crossref","unstructured":"Huang H Manton KG . 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