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Primary antibody deficiency can present at any age. The hallmark clinical presentation is recurrent bacterial infection, but these disorders are also associated with a wide variety of other infectious and non-infectious complications and with a high incidence of chronic, structural tissue damage, particularly in the respiratory tract. Clinical recognition of primary antibody deficiency is frequently delayed with consequent increased morbidity, diminished quality of life and early mortality. Clinical laboratories can contribute to improved and timely detection through awareness of routine test results which may be overtly or indirectly suggestive of antibody deficiency. Secondary deficiency is associated with increased awareness, better recognition and earlier diagnosis than in primary disorders. Early liaison and referral of patients with suspected antibody deficiency for specialist opinion and prompt, appropriate therapy is central to the achievement of good clinical outcomes.<\/jats:p>","DOI":"10.1136\/jcp.2007.051177","type":"journal-article","created":{"date-parts":[[2008,8,28]],"date-time":"2008-08-28T13:24:56Z","timestamp":1219929896000},"page":"994-1000","source":"Crossref","is-referenced-by-count":16,"title":["Antibody deficiency: Table 1"],"prefix":"10.1136","volume":"61","author":[{"given":"R","family":"Herriot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W A C","family":"Sewell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2008,8,28]]},"reference":[{"key":"2025121400264823000_61.9.994.1","first-page":"306","article-title":"The European internet-based patient and research database for primary immunodeficiencies: 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