{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:17:17Z","timestamp":1790763437595,"version":"4.1.0"},"reference-count":19,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p>\n                    Angioimmunoblastic T cell lymphoma (AILT) is an aggressive T cell lymphoma with an incidence of approximately 1\u20132% of all non-Hodgkin lymphoma. The detection of clonal T cell receptor (TCR) gene rearrangements helps in the diagnosis of T cell malignancies such as AILT, where morphological and immunohistological investigations are not always sufficient to reach a definitive diagnosis. TCR \u03b2 (\n                    <jats:italic>TCRB<\/jats:italic>\n                    ) and TCR \u03b3 (\n                    <jats:italic>TCRG<\/jats:italic>\n                    ) gene rearrangements were analysed from 17 WHO-defined cases of AILT by PCR for the presence of TCR clonality.\n                    <jats:italic>TCRB<\/jats:italic>\n                    gene rearrangements were sequenced to identify molecular signature(s) common among this patient group. Monoclonal and oligoclonal\n                    <jats:italic>TCRB<\/jats:italic>\n                    and\n                    <jats:italic>TCRG<\/jats:italic>\n                    gene rearrangements were detected in all cases. BV17S1 was slightly over-represented compared to the use of other V\n                    <jats:italic>\u03b2<\/jats:italic>\n                    gene segments; however, no preferential usage of J gene segment(s) was detected. The results of this study emphasise that TCR clonality and oligoclonality is a diagnostic feature of AILT and that BV17S1 is over-represented with no other common molecular findings.\n                  <\/jats:p>","DOI":"10.1136\/jcp.2007.054239","type":"journal-article","created":{"date-parts":[[2008,10,24]],"date-time":"2008-10-24T20:33:50Z","timestamp":1224880430000},"page":"177-181","source":"Crossref","is-referenced-by-count":6,"title":["Monoclonality and oligoclonality of T cell receptor\n                    <i>\u03b2<\/i>\n                    gene in angioimmunoblastic T cell lymphoma"],"prefix":"10.1136","volume":"62","author":[{"given":"Z H","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J L","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Hodges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2008,10,24]]},"reference":[{"key":"2025120618334295000_62.2.177.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)90553-4"},{"key":"2025120618334295000_62.2.177.2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.2.627"},{"key":"2025120618334295000_62.2.177.3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1083"},{"key":"2025120618334295000_62.2.177.4","doi-asserted-by":"publisher","DOI":"10.1038\/35018581"},{"key":"2025120618334295000_62.2.177.5","unstructured":"Jaffe ES Ralfkiaer E . Angioimmunoblastic T-cell lymphoma. In: Jaffe E S HarrisNL Stein H Vardiman J W , eds. Pathology and genetics of tumors of haematopoietic and lymphoid tissues. World Health Organization Classification of Tumors. Lyon: IARC Press, 2001:3."},{"key":"2025120618334295000_62.2.177.6","first-page":"392","article-title":"Clonal T-cell populations in angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma.","volume":"3","author":"Weiss","year":"1986","journal-title":"Am J Pathol"},{"key":"2025120618334295000_62.2.177.7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112860"},{"key":"2025120618334295000_62.2.177.8","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0002-9440(10)64770-0","article-title":"Frequent T and B cell oligoclones in histologically and immunophenotypically characterized angioimmunoblastic lymphodenopathy.","volume":"2","author":"Smith","year":"2000","journal-title":"Am J Pathol"},{"key":"2025120618334295000_62.2.177.9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404481"},{"key":"2025120618334295000_62.2.177.10","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403202"},{"key":"2025120618334295000_62.2.177.11","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700304"},{"key":"2025120618334295000_62.2.177.12","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.1.165"},{"key":"2025120618334295000_62.2.177.13","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0320(20000801)40:4<336::AID-CYTO9>3.0.CO;2-0"},{"key":"2025120618334295000_62.2.177.14","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200208000-00018"},{"key":"2025120618334295000_62.2.177.15","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1182\/blood.V83.2.587.587","article-title":"Oligoclonal expansion of CD8+CD57+ T cells with restricted T cell receptor \u03b2 chain variability after bone marrow transplantation.","volume":"83","author":"Gorochov","year":"1994","journal-title":"Blood"},{"key":"2025120618334295000_62.2.177.16","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12667988"},{"key":"2025120618334295000_62.2.177.17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02022.x"},{"key":"2025120618334295000_62.2.177.18","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.10.6038"},{"key":"2025120618334295000_62.2.177.19","doi-asserted-by":"crossref","first-page":"7614","DOI":"10.1128\/jvi.68.11.7614-7619.1994","article-title":"Preferential usage of T-cell receptor V\u03b217 by Dengue virus-specific human T lymphocytes in a donor with immunity to Dengue virus type 4.","volume":"68","author":"Okamoto","year":"1994","journal-title":"J Virol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2007.054239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:33:47Z","timestamp":1765074827000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2007.054239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,24]]},"references-count":19,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,1,29]]},"published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1136\/jcp.2007.054239"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2007.054239","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,24]]}}}