{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T05:56:43Z","timestamp":1770357403353,"version":"3.49.0"},"reference-count":6,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2008,6,17]]},"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p>\n                    Disseminated cryptococcosis is an uncommon occurrence in immunocompetent populations and occurs mainly in immunocompromised patients. The first case of cryptococcus meningitis and skin lesions in a 4-year-old confirmed HIV negative boy who presented with fever, meningism and skin lesions is reported. On examination the child was confused, uncooperative, and had neck stiffness and raised skin lesions. A septic screen, including skin scraping, was performed; the child was treated with penicillin and ceftriaxone for suspected meningococcal meningitis. The cerebrospinal fluid (CSF) had normal protein, glucose and chloride levels; yeasts were observed on Gram stain from the CSF and skin scraping. The India ink stain and\n                    <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                    latex agglutination test on the CSF were both positive. Bacterial culture of the skin biopsy, CSF and blood culture specimens was negative. The child was treated with amphotericin B based on preliminary results, and had a gradual recovery with no neurological sequelae. The child continued oral fluconazole.\n                  <\/jats:p>","DOI":"10.1136\/jcp.2008.056119","type":"journal-article","created":{"date-parts":[[2008,7,19]],"date-time":"2008-07-19T20:25:13Z","timestamp":1216499113000},"page":"1138-1139","source":"Crossref","is-referenced-by-count":13,"title":["Cryptococcus meningitis and skin lesions in an HIV negative child"],"prefix":"10.1136","volume":"61","author":[{"given":"K","family":"Swe Swe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Bekker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Greeff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D R","family":"Perkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2008,7,19]]},"reference":[{"key":"2025120600465925000_61.10.1138.1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.11.3889-3894.2001"},{"key":"2025120600465925000_61.10.1138.2","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1128\/CMR.8.4.515","article-title":"Cryptococcosis in the era of AIDS\u2014100 years after the discovery of Cryptococcus neoformans.","volume":"8","author":"Mitchell","year":"1995","journal-title":"Clin Microbiol Rev"},{"key":"2025120600465925000_61.10.1138.3","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-94-5-611"},{"key":"2025120600465925000_61.10.1138.4","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.2.527"},{"key":"2025120600465925000_61.10.1138.5","unstructured":"Betts RF Chapman SW Penn RL . Reese and Betts\u2019 A practical approach to infectious diseases , 5th edn. Philadelphia, PA: Lippincott Williams & Wilkins, 2003:603\u20134."},{"key":"2025120600465925000_61.10.1138.6","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.8.3098-3099.2002"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2008.056119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:47:07Z","timestamp":1765010827000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2008.056119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,19]]},"references-count":6,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2008,9,26]]},"published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1136\/jcp.2008.056119"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2008.056119","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,19]]}}}