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The present document includes comments on the need for accuracy and standardisation, and on the interpretation of the HbA<jats:sub>2<\/jats:sub> value, reviewing the most crucial aspects related to this test. A practical flow-chart is presented to summarise the significance of HbA<jats:sub>2<\/jats:sub> estimation in different thalassaemia syndromes and related haemoglobinopathies.<\/jats:p>","DOI":"10.1136\/jcp.2008.056945","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T15:05:56Z","timestamp":1229958356000},"page":"13-17","source":"Crossref","is-referenced-by-count":147,"title":["The role of haemoglobin A<sub>2<\/sub> testing in the diagnosis of thalassaemias and related haemoglobinopathies"],"prefix":"10.1136","volume":"62","author":[{"given":"A","family":"Mosca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Paleari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Ivaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Galanello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P C","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2008,12,22]]},"reference":[{"key":"2025092503324546000_62.1.13.1","doi-asserted-by":"publisher","DOI":"10.1126\/science.122.3163.288"},{"key":"2025092503324546000_62.1.13.2","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1172\/JCI103561","article-title":"Observation of the minor basic haemoglobin component in blood of normal individuals and patients with thalassaemia.","volume":"36","author":"Kunkel","year":"1957","journal-title":"J Clin Invest"},{"key":"2025092503324546000_62.1.13.3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1182\/blood.V13.1.61.61","article-title":"The diagnosis of thalassaemia trait by starch block electrophoresis of haemoglobin.","volume":"13","author":"Gerald","year":"1958","journal-title":"Blood"},{"key":"2025092503324546000_62.1.13.4","unstructured":"Weatherall DJ Clegg JB . 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