{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:03:53Z","timestamp":1782601433020,"version":"3.54.5"},"reference-count":26,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2008,7,1]]},"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The relationship between tumefactive lesions classified as sclerosing mesenteritis and IgG4-related sclerosing disorders (eg, lymphoplasmacytic sclerosing pancreatitis\/autoimmune pancreatitis) remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To review lesions coded as \u201csclerosing mesenteritis\u201d for findings in keeping with IgG4-related sclerosing disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Inclusion in the study required available paraffin blocks for IgG4 staining and documentation of a mass lesion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of nine mesenteric lesions (3\u201314 cm) were identified in 6 male and 3 female patients. On H&amp;E-stained sections, all were characterised as loosely marginated fibroinflammatory processes with variable amounts of fat necrosis. Lymphocytic venulitis\/phlebitis was identified in 8 of 9 cases. IgG and IgG4 expression in lesional plasma cells was assessed by immunohistochemistry. IgG4-positive plasma cells were counted in the areas of greatest density in \u2a7e3 high power fields (HPFs). The highest number per HPF was recorded and a score assigned based on the following scale: &lt;5\/HPF, none\/minimal; 5\u201310\/HPF, mild; 11\u201330\/HPF, moderate; &gt;30\/HPF, marked. The relative proportion of IgG4-reactive plasma cells to total IgG-positive plasma cells was assessed. IgG4-reactive plasma cells ranged from 0 to &gt;100 in the most dense zones (3 cases, none\/minimal; 4 cases, moderate; 2 cases, marked).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Although this study is limited by small numbers, findings suggest that some tumefactive lesions regarded as sclerosing mesenteritis may be a subset of IgG4-related sclerosing disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jcp.2008.057869","type":"journal-article","created":{"date-parts":[[2008,8,5]],"date-time":"2008-08-05T23:29:03Z","timestamp":1217978943000},"page":"1093-1097","source":"Crossref","is-referenced-by-count":78,"title":["Are tumefactive lesions classified as sclerosing mesenteritis a subset of IgG4-related sclerosing disorders?"],"prefix":"10.1136","volume":"61","author":[{"given":"T S","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E A","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2008,8,4]]},"reference":[{"key":"2025112110221880000_61.10.1093.1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199704000-00004"},{"key":"2025112110221880000_61.10.1093.2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-66-5-884"},{"key":"2025112110221880000_61.10.1093.3","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.5.683"},{"key":"2025112110221880000_61.10.1093.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1175-y"},{"key":"2025112110221880000_61.10.1093.5","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000011618.74277.6d"},{"key":"2025112110221880000_61.10.1093.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-007-2045-9"},{"key":"2025112110221880000_61.10.1093.7","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpa.0000175178.85786.1d"},{"key":"2025112110221880000_61.10.1093.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra061200"},{"key":"2025112110221880000_61.10.1093.9","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200308000-00009"},{"key":"2025112110221880000_61.10.1093.10","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200301000-00012"},{"key":"2025112110221880000_61.10.1093.11","doi-asserted-by":"publisher","DOI":"10.1159\/000090033"},{"key":"2025112110221880000_61.10.1093.12","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800836"},{"key":"2025112110221880000_61.10.1093.13","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000147399.10639.f5"},{"key":"2025112110221880000_61.10.1093.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.05.011"},{"key":"2025112110221880000_61.10.1093.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.02.032"},{"key":"2025112110221880000_61.10.1093.16","doi-asserted-by":"crossref","first-page":"582","DOI":"10.7326\/0003-4819-80-5-582","article-title":"Mesenteric lipodystrophy.","volume":"80","author":"Kipfer","year":"1974","journal-title":"Ann Intern Med"},{"key":"2025112110221880000_61.10.1093.17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103083441005"},{"key":"2025112110221880000_61.10.1093.18","first-page":"115A","article-title":"Is IgG4 specific for lymphoplasmacytic sclerosing pancreatitis and fimilar fibroinflammatory lesions?","volume":"21","author":"Chen","year":"2008","journal-title":"Mod Pathol"},{"key":"2025112110221880000_61.10.1093.19","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1093\/ajcp\/65.3.274","article-title":"Occlusive phlebitis in multifocal fibrosclerosis.","volume":"65","author":"Meyer","year":"1976","journal-title":"Am J Clin Pathol"},{"key":"2025112110221880000_61.10.1093.20","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1097\/00000478-199408000-00003","article-title":"Mesenteric inflammatory veno-occlusive disease. 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