{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:44:15Z","timestamp":1764996255426,"version":"3.46.0"},"reference-count":11,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2008,6,19]]},"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Endoscopy and biopsy are used to diagnose coeliac disease. There are, however, observer-dependent interpretations of the degree of villous atrophy in biopsies. A pilot study using quantitative image-processing procedures was performed to quantify the degree of villous atrophy in patients with coeliac disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>The degree of villous atrophy in duodenal biopsy images was quantified by calculating the ratio of villous edge-to-piecewise arc length (E\/P ratio), and this value was compared with the blinded assessment of Marsh score for degree of villous atrophy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Mean E\/P ratios for n\u200a=\u200a31 biopsy images, 2.76 (SD 0.44) (Marsh IIIa), 1.91 (0.50) (Marsh IIIb) and 1.18 (0.22) (Marsh IIIc), were significantly different (p\u200a=\u200a0.006). Based on non-parametric testing, the E\/P ratios were inversely correlated with Marsh scores (Spearman coefficient \u03c1\u200a=\u200a\u22120.798, Kendall \u03c4\u200a=\u200a\u22120.681; p&lt;0.0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Biopsy images quantified by image analysis correlated exceedingly well with the histopathological grade of villous atrophy. Since quantified measurements are real-numbered values and lack observer bias, measurement of villous atrophy based on image analysis lends itself to standardisation of histological grading.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jcp.2008.058669","type":"journal-article","created":{"date-parts":[[2008,7,19]],"date-time":"2008-07-19T20:25:13Z","timestamp":1216499113000},"page":"1089-1093","source":"Crossref","is-referenced-by-count":14,"title":["Quantitative assessment of the degree of villous atrophy in patients with coeliac disease"],"prefix":"10.1136","volume":"61","author":[{"given":"E J","family":"Ciaccio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Bhagat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Naiyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P H R","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2008,7,19]]},"reference":[{"key":"2025120520181221000_61.10.1089.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071600"},{"key":"2025120520181221000_61.10.1089.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021687"},{"key":"2025120520181221000_61.10.1089.3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.3.286"},{"key":"2025120520181221000_61.10.1089.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2005.02.006"},{"key":"2025120520181221000_61.10.1089.5","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.47.8.693"},{"key":"2025120520181221000_61.10.1089.6","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200501000-00017"},{"key":"2025120520181221000_61.10.1089.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.03.019"},{"key":"2025120520181221000_61.10.1089.8","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0016-5085(92)91819-P","article-title":"Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (\u201cceliac sprue\u201d).","volume":"102","author":"Marsh","year":"1992","journal-title":"Gastroenterology"},{"key":"2025120520181221000_61.10.1089.9","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1097\/00042737-199910000-00019","article-title":"The histopathology of coeliac disease: time for a standardized report scheme for pathologists.","volume":"11","author":"Oberhuber","year":"1999","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025120520181221000_61.10.1089.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(01)80003-2"},{"key":"2025120520181221000_61.10.1089.11","unstructured":"Russ JC . The image processing handbook. Boca Raton: CRC Press, 1995."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2008.058669","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:18:19Z","timestamp":1764994699000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2008.058669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,19]]},"references-count":11,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2008,9,26]]},"published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1136\/jcp.2008.058669"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2008.058669","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[2008,7,19]]}}}