{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:39:22Z","timestamp":1791297562395,"version":"4.1.0"},"reference-count":8,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2008,10,3]]},"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>As a result of population growth in African-Caribbean regions of overseas France, and now immigration essentially from North and sub-Saharan Africa to mainland France, neonatal screening for sickle cell disease (SCD) has been performed in France since 1985 in Guadalupe and dependencies, as a universal test. After several pilot studies, screening was gradually extended to mainland France in 1996. Since 2000, the test has been performed at national level for all newborns defined as being \u201cat risk\u201d for SCD based on ethnic origin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A dry blood sample is obtained by heel stick and analysed by isoelectric focusing as a first-line method, followed by either high-performance liquid chromatography or acid agar electrophoresis for confirmation, whenever a variant haemoglobin is observed on isoelectric focusing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In 2007, 28.45% of all newborns in mainland France were screened for SCD. Since 1996, a total of 3890 newborns have been found to have SCD, and they have been followed up by reference paediatricians.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although screening for SCD at birth in France is not universal, it appears that missed babies are relatively infrequent. Despite obvious sociological problems inherent to the at-risk population, the follow-up of SCD babies is rather successful. Due to the birth prevalence of SCD in France, especially in comparison with other common genetic diseases, screening all newborns regardless of ethnic origin is an issue that is being addressed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jcp.2008.058867","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T15:05:56Z","timestamp":1229958356000},"page":"31-33","source":"Crossref","is-referenced-by-count":56,"title":["Neonatal screening for sickle cell disease in France"],"prefix":"10.1136","volume":"62","author":[{"given":"J","family":"Bardakdjian-Michau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bahuau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Hurtrel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Godart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Riou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Mathis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Goossens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2008,12,22]]},"reference":[{"key":"2025120619032761000_62.1.31.1","first-page":"1531","article-title":"Epid\u00c3\u00a9miologie de la dr\u00c3\u00a9panocytose [Epidemiology of sickle cell anemia].","volume":"54","author":"Bardakdjian","year":"2004","journal-title":"Rev Prat"},{"key":"2025120619032761000_62.1.31.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-693X(08)71894-3"},{"key":"2025120619032761000_62.1.31.3","unstructured":"Association Fran\u00c3\u00a7aise pour le D\u00c3\u00a9pistage et la Pr\u00c3\u00a9vention du Handicap de l\u00e2\u0080\u0099Enfant. Bilan d\u00e2\u0080\u0099activit\u00c3\u00a9 2007 (personal communication). http:\/\/www.afdphe.asso.fr (accessed 4 November 2008)."},{"key":"2025120619032761000_62.1.31.4","doi-asserted-by":"publisher","DOI":"10.1081\/HEM-120015024"},{"key":"2025120619032761000_62.1.31.5","unstructured":"Haute Autorit\u00c3\u00a9 de Sant\u00c3\u00a9. Recommandations pour la pratique clinique: Prise en charge de la dr\u00c3\u00a9panocytose chez l\u00e2\u0080\u0099enfant et l\u00e2\u0080\u0099adolescent (September 2005). http:\/\/www.has-sante.fr\/ (accessed 4 November 2008),"},{"key":"2025120619032761000_62.1.31.6","first-page":"241","article-title":"Origin and spread of beta-globin gene mutations in India, Africa, and Mediterranean: analysis of the 5\u00e2\u0080\u00b2 flanking and intragenic sequences of beta S and beta C genes.","volume":"63","author":"Trabuchet","year":"1991","journal-title":"Hum Biol"},{"key":"2025120619032761000_62.1.31.7","first-page":"401","article-title":"Bonnes pratiques de l\u00e2\u0080\u0099\u00c3\u00a9tude de l\u00e2\u0080\u0099h\u00c3\u00a9moglobine.","volume":"61","author":"Bardakdjian-Michau","year":"2003","journal-title":"Ann Biol Clin"},{"key":"2025120619032761000_62.1.31.8","unstructured":"Haute Autorit\u00c3\u00a9 de Sant\u00c3\u00a9. Guide \u00e2\u0080\u0093 Affection de Longue Dur\u00c3\u00a9e: Syndromes thalass\u00c3\u00a9miques majeurs et interm\u00c3\u00a9diaires. Protocole national de diagnostic et de soins pour une maladie rare. 2008. http:\/\/www.has-sante.fr\/ (accessed 4 November 2008)."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2008.058867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:03:37Z","timestamp":1765076617000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2008.058867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,22]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2008,12,22]]},"published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1136\/jcp.2008.058867"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2008.058867","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,22]]}}}