{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:30:53Z","timestamp":1792150253826,"version":"4.4.0"},"reference-count":16,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2008,10,3]]},"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:sec>\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>Despite the high prevalence of sickle cell disease in Africa, a neonatal screening programme is available in only a few countries in the sub-Saharan region.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim:<\/jats:title>\n                  <jats:p>To describe our experience of a pioneer study on 31\u2009304 newborns screened systematically in the Democratic Republic of the Congo.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>The prevalence of haemoglobinopathies was determined by a thin-layer isoelectric focusing method on dry filter-paper samples.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Of the 31\u2009204 newborns screened by isoelectric focusing, 5276 (16.9%) displayed sickle cell trait and 428 (1.4%) were homozygous for haemoglobin S. No statistical differences were observed in the different ethno-linguistic groups, but some tribes displayed a higher prevalence of the \u03b2S gene, attributable to a higher prevalence of malaria, and a greater frequency of haemoglobin S homozygotes, in part attributable to an endogamic marriage system.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>The neonatal screening programme has now been introduced in the Democratic Republic of the Congo, but the main challenges are to track all the new cases for a confirmatory test and to initiate early management.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jcp.2008.058958","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T15:05:56Z","timestamp":1229958356000},"page":"35-38","source":"Crossref","is-referenced-by-count":154,"title":["Neonatal screening for sickle cell anaemia in the Democratic Republic of the Congo: experience from a pioneer project on 31\u2009204 newborns"],"prefix":"10.1136","volume":"62","author":[{"given":"L","family":"Tshilolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L M","family":"Aissi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Lukusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Kinsiama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Wembonyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Gulbis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Vertongen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2008,12,22]]},"reference":[{"key":"2025092505324535000_62.1.35.1","doi-asserted-by":"crossref","unstructured":"Weatherall DJ Akinyanju O Fucharoen S . Inherited disorders of hemoglobin. In: Disease control priorities in developing countries. In: Jamison D T Bobadilla J - S Mosley W H Measham A R , eds. New York: Oxford University Press and the World Bank, 2006:663\u00e2\u0080\u009380.","DOI":"10.1596\/978-0-8213-6179-5\/Chpt-34"},{"key":"2025092505324535000_62.1.35.2","first-page":"447","article-title":"M\u00c3\u00a9decine et sant\u00c3\u00a9 en R\u00c3\u00a9publique D\u00c3\u00a9mocratique du Congo: de l\u00e2\u0080\u0099ind\u00c3\u00a9pendance \u00c3\u00a0 la 3\u00c3\u00a8 r\u00c3\u00a9publique.","volume":"67","author":"Wembonyama","year":"2007","journal-title":"Med Trop"},{"key":"2025092505324535000_62.1.35.3","unstructured":"Saint Moulin L de. Panorama de l\u00e2\u0080\u0099histoire contemporaine. Kinshasa: Ed. de la Commission Episcopale de l\u00e2\u0080\u0099Education Chr\u00c3\u00a9tienne, 1983."},{"key":"2025092505324535000_62.1.35.4","unstructured":"World Health Organization. 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