{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:28:13Z","timestamp":1780514893262,"version":"3.54.1"},"reference-count":21,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To investigate the correlation of various diagnostic cytological features in SurePath liquid-based cell preparations with high-risk human papillomavirus (HPV) infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Case\u2013control study. SurePath specimens from 510 cases that had been tested for HPV DNA by Hybrid Capture 2 assay were retrieved and re-examined for 10 cytological features. Distribution of these features in high- and low-risk HPV types was compared and risk statistics were estimated. Effects of cervicitis on the manifestation of HPV cytological changes were adjusted by means of logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Cytological features of nuclear hyperchromasia, multinucleation and atypical metaplastic cells were predominantly noted in high-risk HPV infection in the category of atypical squamous cells of undetermined significance\/low-grade squamous intraepithelial lesion. The odds ratios of these three features were 6\u201312 times higher in high-risk than low-risk HPV infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Some diagnostic cytological features can be used as markers in Pap smear screening for assessing the types of HPV infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jcp.2008.059881","type":"journal-article","created":{"date-parts":[[2008,8,29]],"date-time":"2008-08-29T20:24:34Z","timestamp":1220041474000},"page":"1317-1322","source":"Crossref","is-referenced-by-count":7,"title":["Cytological distinction between high-risk and low-risk human papillomavirus infections in SurePath liquid-based cell preparations"],"prefix":"10.1136","volume":"61","author":[{"given":"N K S","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F Y","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2008,8,29]]},"reference":[{"key":"2025121322070685000_61.12.1317.1","unstructured":"Ferlay J Bray F Pisani P . 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