{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:08:18Z","timestamp":1782252498371,"version":"3.54.5"},"reference-count":9,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2008,7,28]]},"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p>Perivascular epithelioid cell tumour (PEComa) is a term applied to a family of mesenchymal tumours composed of varying proportions of spindle and epithelioid cell components associated with HMB-45 expression. PEComa rarely arises in the soft tissue, visceral organs, skin and bone. This report details an instance when a purely epithelioid PEComa arose from the right fibula of a 52-year-old Chinese woman without features of tuberous sclerosis complex. The excision specimen disclosed an epithelioid tumour with a nested pattern associated with areas of nuclear pleomorphism, mitotic activity, necrosis and vascular invasion in addition to HMB-45 expression on immunohistochemistry. To the best of the authors\u2019 knowledge, this represents the first case of a histologically malignant PEComa of the bone. A short review of primary bone PEComas and potential problems in diagnosis is presented.<\/jats:p>","DOI":"10.1136\/jcp.2008.060137","type":"journal-article","created":{"date-parts":[[2008,9,26]],"date-time":"2008-09-26T13:27:49Z","timestamp":1222435669000},"page":"1127-1129","source":"Crossref","is-referenced-by-count":22,"title":["Malignant perivascular epithelioid cell tumour of the fibula: a report and a short review of bone perivascular epithelioid cell tumour"],"prefix":"10.1136","volume":"61","author":[{"given":"D W Q","family":"Lian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K L","family":"Chuah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M H W","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W M","family":"Yap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2008,9,26]]},"reference":[{"key":"2025120523434744000_61.10.1127.1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/00000478-199203000-00013","article-title":"PEC and sugar.","volume":"16","author":"Bonetti","year":"1992","journal-title":"Am J Surg Pathol"},{"key":"2025120523434744000_61.10.1127.2","unstructured":"Folpe AL . Neoplasms with perivascular epithelioid cell differentiation (PEComas). In: Fletcher C D M Unni K K Mertens F , eds. Pathology and genetics of tumours of soft tissue and bone. Lyon: IARC Press, 2002:221\u00e2\u0080\u00932."},{"key":"2025120523434744000_61.10.1127.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02316.x"},{"key":"2025120523434744000_61.10.1127.4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01356.x"},{"key":"2025120523434744000_61.10.1127.5","doi-asserted-by":"publisher","DOI":"10.1177\/1066896907309733"},{"key":"2025120523434744000_61.10.1127.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-008-0612-y"},{"key":"2025120523434744000_61.10.1127.7","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000128668.34934.81"},{"key":"2025120523434744000_61.10.1127.8","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000173232.22117.37"},{"key":"2025120523434744000_61.10.1127.9","doi-asserted-by":"publisher","DOI":"10.1080\/00313020600922504"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2008.060137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:43:53Z","timestamp":1765007033000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2008.060137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,26]]},"references-count":9,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2008,9,26]]},"published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1136\/jcp.2008.060137"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2008.060137","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,26]]}}}