{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:07:53Z","timestamp":1791281273811,"version":"4.1.0"},"reference-count":13,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2008,10,3]]},"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>A neonatal haemoglobinopathy screening programme was implemented in Brussels more than a decade ago and in Li\u00e8ge 5 years ago; the programme was adapted to the local situation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Neonatal screening for haemoglobinopathies was universal, performed using liquid cord blood and an isoelectric focusing technique. All samples with abnormalities underwent confirmatory testing. Major and minor haemoglobinopathies were reported. Affected children were referred to a specialist centre. A central database in which all screening results were stored was available and accessible to local care workers. A central clinical database to monitor follow-up is under construction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 191\u2009783 newborns were screened. One hundred and twenty-three (1:1559) newborns were diagnosed with sickle cell disease, seven (1:27\u2009398) with \u03b2 thalassaemia major, five (1:38\u200a357) with haemoglobin H disease, and seven (1:27\u200a398) with haemoglobin C disease. All major haemoglobinopathies were confirmed, and follow-up of the infants was undertaken except for three infants who did not attend the first medical consultation despite all efforts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The universal neonatal screening programme was effective because no case of major haemoglobinopathy was identified after the neonatal period. The affected children received dedicated medical care from birth. The screening programme, and specifically the reporting of minor haemoglobinopathies, has been an excellent health education tool in Belgium for more than 12 years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jcp.2008.060517","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T15:05:56Z","timestamp":1229958356000},"page":"49-52","source":"Crossref","is-referenced-by-count":46,"title":["Neonatal haemoglobinopathy screening in Belgium"],"prefix":"10.1136","volume":"62","author":[{"given":"B","family":"Gulbis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Cotton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ferster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Ketelslegers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M F","family":"Dresse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Rong\u00e9-Collard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Minon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P Q","family":"L\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Vertongen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2008,12,22]]},"reference":[{"key":"2025120618361840000_62.1.49.1","doi-asserted-by":"publisher","DOI":"10.1080\/00365510601046557"},{"key":"2025120618361840000_62.1.49.2","doi-asserted-by":"publisher","DOI":"10.1080\/03630260802004400"},{"key":"2025120618361840000_62.1.49.3","doi-asserted-by":"publisher","DOI":"10.1080\/00365510601046466"},{"key":"2025120618361840000_62.1.49.4","unstructured":"NHS Antenatal And Neonatal Newborn Screening Programmes. NHS Sickle Cell and Thalassaemia Screening Programme. http:\/\/www.kcl-phs.org.uk\/haemscreening\/ (accessed 27 October 2008)."},{"key":"2025120618361840000_62.1.49.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2006.06.006"},{"key":"2025120618361840000_62.1.49.6","unstructured":"AFDPHE. Association fran\u00e7aise pour le d\u00e9pistage et la prevention des handicaps de l\u2019enfant. http:\/\/www.afdphe.asso.fr (accessed 27 October 2008)."},{"key":"2025120618361840000_62.1.49.7","doi-asserted-by":"publisher","DOI":"10.1136\/jms.6.1.11"},{"key":"2025120618361840000_62.1.49.8","first-page":"1565","article-title":"The use of capillary blood samples in a large scale screening approach for the detection of \u03b2-thalassemia and hemoglobin variants.","volume":"91","author":"Bento","year":"2006","journal-title":"Haematologica"},{"key":"2025120618361840000_62.1.49.9","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2006.059"},{"key":"2025120618361840000_62.1.49.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05646.x"},{"key":"2025120618361840000_62.1.49.11","unstructured":"Blomberg K Kankaanp\u00e4\u00e4 P Campbell T , inventors. Hemoglobin assay for neonatal screening. World patent WO\/2005\/029092. 31 March 2005. http:\/\/www.wipo.int\/pctdb\/en\/wo.jsp?IA\u200a=\u200aFI2004000551&DISPLAY\u200a=\u200aDESC (accessed 27 October 2008)."},{"key":"2025120618361840000_62.1.49.12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta4030","article-title":"Screening for sickle cell disease and thalassemia: a systematic review with supplementary research.","volume":"4","author":"Davies","year":"2000","journal-title":"Health Technol Assess"},{"key":"2025120618361840000_62.1.49.13","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1136\/bmj.313.7054.407","article-title":"Fortnightly review: neonatal screening for sickle cell disorders: what about the carrier infants?","volume":"313","author":"Laird","year":"1996","journal-title":"BMJ"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2008.060517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:36:26Z","timestamp":1765074986000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2008.060517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,22]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2008,12,22]]},"published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1136\/jcp.2008.060517"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2008.060517","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,22]]}}}