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Histology and immunohistochemistry disclosed atypical stromal cells with irregular voluminous nuclei positive for vimentin and smooth muscle actin; these cells were reminiscent of those previously reported in a subset of nasal polyps showing aneuploidy. The scarce lymphoplasmocytic infiltrate hindering the diagnosis of inflammatory myofibroblastic tumours (IMT), and the presence of atypical cells, prompted the use of FISH: lack of\n                    <jats:italic>ALK<\/jats:italic>\n                    gene rearrangement and aneuploidy were observed in the irregular nuclei, supporting the diagnosis of a pseudosarcomatous myofibroblastic proliferation (PMP). These results stress that IMT and PMP may represent variants within a spectrum of myofibroblastic proliferations\/tumours.\n                  <\/jats:p>","DOI":"10.1136\/jcp.2008.060608","type":"journal-article","created":{"date-parts":[[2008,12,3]],"date-time":"2008-12-03T20:35:23Z","timestamp":1228336523000},"page":"377-379","source":"Crossref","is-referenced-by-count":2,"title":["Would a morphomolecular approach help in defining pseudosarcomatous myofibroblastic proliferations? A study of a heart polypoid lesion: Figure 1"],"prefix":"10.1136","volume":"62","author":[{"given":"S","family":"Nemolato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Dettori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Caria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D V","family":"Frau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Faa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Vanni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2008,12,3]]},"reference":[{"key":"2025120619194929000_62.4.377.1","unstructured":"Burke A Tazelaar H Gomez-Roman J . Tumours of the heart. In: Travis W Brambilla E Muller-Hermelink H Harris C , eds. Pathology and genetics of tumours of the lung, pleura, thymus and heart. Lyon: IARC Press, 2004:260\u20133."},{"key":"2025120619194929000_62.4.377.2","first-page":"2776","article-title":"Recurrency involvement of 2p23 in inflammatory myofibroblastic tumors.","volume":"59","author":"Griffin","year":"1999","journal-title":"Cancer Res"},{"key":"2025120619194929000_62.4.377.3","unstructured":"Mitelman F Johansson B Mertens F , eds. 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St Louis (MO): Mosby, 2001:293\u20135."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2008.060608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:20:00Z","timestamp":1765077600000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2008.060608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,3]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,3,27]]},"published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1136\/jcp.2008.060608"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2008.060608","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[2008,12,3]]}}}