{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T09:28:30Z","timestamp":1768642110362,"version":"3.49.0"},"reference-count":29,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2009,1,29]]},"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To perform a clinicopathological analysis of a series of primary cutaneous Ewing sarcomas\/primitive neuroectodermal tumours (ES\/PNET) to highlight the pathological features, discuss the differential diagnosis, emphasise the role of molecular testing (particularly fluorescence in situ hybridisation, FISH) in diagnosis and outline the patients\u2019 clinical course.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Seven cases of primary cutaneous ES\/PNET were identified from the authors\u2019 consultation files.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The patients were aged 16\u201361 years (median 25). Five were female and two were male. Five cases involved the limbs and two the trunk. Five were initially misdiagnosed (three as carcinoma and two as melanoma). All cases were characterised histologically by sheet-like growth of small round cells with little cytoplasm and showed strong membranous staining for CD99 and positive but variable staining for FLI-1. Six patients showed an EWS rearrangement (five on FISH analysis and one on RT-PCR). All tumours were completely excised. Three patients received adjuvant chemotherapy, one of whom also received radiotherapy. Follow-up was available in all cases (range 11\u201357 months; median 41). No recurrences or metastases occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Although rare, primary cutaneous ES\/PNET should be considered in the differential diagnosis of cutaneous \u201csmall blue cell tumours\u201d. Immunostaining for FLI-1 and molecular testing for evidence of an EWS rearrangement are useful ancillary investigations to confirm the diagnosis. The prognosis of primary cutaneous ES\/PNET appears to be more favourable than extracutaneous ES\/PNET.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jcp.2008.064014","type":"journal-article","created":{"date-parts":[[2009,9,25]],"date-time":"2009-09-25T15:37:06Z","timestamp":1253893026000},"page":"915-919","source":"Crossref","is-referenced-by-count":42,"title":["Primary cutaneous Ewing sarcoma\/primitive neuroectodermal tumour: a clinicopathological analysis of seven cases highlighting diagnostic pitfalls and the role of FISH testing in diagnosis"],"prefix":"10.1136","volume":"62","author":[{"given":"M V","family":"Shingde","sequence":"first","affiliation":[{"name":"Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Buckland","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, St Vincent\u2019s Hospital, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K J","family":"Busam","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S W","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia"},{"name":"Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, NSW, Australia"},{"name":"Discipline of Pathology, The University of Sydney, NSW, Australia"},{"name":"Melanoma Institute Australia, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Wilmott","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia"},{"name":"Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, NSW, Australia"},{"name":"Melanoma Institute Australia, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J F","family":"Thompson","sequence":"additional","affiliation":[{"name":"Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, NSW, Australia"},{"name":"Discipline of Surgery, Faculty of Medicine, The University of Sydney, NSW, Australia"},{"name":"Melanoma Institute Australia, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A","family":"Scolyer","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia"},{"name":"Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, NSW, Australia"},{"name":"Discipline of Pathology, The University of Sydney, NSW, Australia"},{"name":"Melanoma Institute Australia, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2009,9,25]]},"reference":[{"key":"2025120519180461000_62.10.915.1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199301000-00001"},{"key":"2025120519180461000_62.10.915.2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(88)90285-3"},{"key":"2025120519180461000_62.10.915.3","unstructured":"Ushigome S Machinami R Sorensen P . Ewing sarcoma\/primitive neuroectodermal tumour (PNET). In: Fletcher CDM Unni KK Mertens F , eds. World Health Organisation classification of tumours. pathology and genetics, tumours of soft tissue and bone. Lyon: IARC Press, 2002:297\u2013300."},{"key":"2025120519180461000_62.10.915.4","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197507)36:1<240::AID-CNCR2820360127>3.0.CO;2-H"},{"key":"2025120519180461000_62.10.915.5","first-page":"17","article-title":"Diffuse endothelioma of bone.","volume":"21","author":"Ewing","year":"1921","journal-title":"Proc N Y Pathol Soc"},{"key":"2025120519180461000_62.10.915.6","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn103"},{"key":"2025120519180461000_62.10.915.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(00)00295-8"},{"key":"2025120519180461000_62.10.915.8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204598"},{"key":"2025120519180461000_62.10.915.9","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800486"},{"key":"2025120519180461000_62.10.915.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00391-0"},{"key":"2025120519180461000_62.10.915.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2006.12.019"},{"key":"2025120519180461000_62.10.915.12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1997.2770865.x"},{"key":"2025120519180461000_62.10.915.13","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-199509000-00004"},{"key":"2025120519180461000_62.10.915.14","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199803000-00005"},{"key":"2025120519180461000_62.10.915.15","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-004-2024-6"},{"key":"2025120519180461000_62.10.915.16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02318.x"},{"key":"2025120519180461000_62.10.915.17","first-page":"216","article-title":"Immunohistochemistry of small round-cell tumors.","volume":"17","author":"Devoe","year":"2000","journal-title":"Semin Diagn Pathol"},{"key":"2025120519180461000_62.10.915.18","first-page":"213","article-title":"Differential diagnosis of small round cell tumors.","volume":"13","author":"Meis-Kindblom","year":"1996","journal-title":"Semin Diagn Pathol"},{"key":"2025120519180461000_62.10.915.19","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910401)67:7<1886::AID-CNCR2820670712>3.0.CO;2-U"},{"key":"2025120519180461000_62.10.915.20","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199208000-00002"},{"key":"2025120519180461000_62.10.915.21","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2006.040931"},{"key":"2025120519180461000_62.10.915.22","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199405000-00008"},{"key":"2025120519180461000_62.10.915.23","first-page":"235","article-title":"MIC2 gene expression in cutaneous neuroendocrine carcinoma (Merkel cell carcinoma).","volume":"4","author":"Soslow","year":"1996","journal-title":"Appl Immunohistochem"},{"key":"2025120519180461000_62.10.915.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2006.11.014"},{"key":"2025120519180461000_62.10.915.25","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20491"},{"key":"2025120519180461000_62.10.915.26","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2811"},{"key":"2025120519180461000_62.10.915.27","first-page":"4568","article-title":"FUS\/ERG gene fusions in Ewing\u2019s tumors.","volume":"63","author":"Shing","year":"2003","journal-title":"Cancer Res"},{"key":"2025120519180461000_62.10.915.28","doi-asserted-by":"publisher","DOI":"10.2353\/jmoldx.2007.070009"},{"key":"2025120519180461000_62.10.915.29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02535.x"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2008.064014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T03:18:16Z","timestamp":1764991096000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2008.064014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,25]]},"references-count":29,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2009,9,25]]},"published-print":{"date-parts":[[2009,10]]}},"alternative-id":["10.1136\/jcp.2008.064014"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2008.064014","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,25]]}}}