{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:54:15Z","timestamp":1764996855670,"version":"3.44.0"},"reference-count":22,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:sec>\n                  <jats:title>Aims:<\/jats:title>\n                  <jats:p>In the absence of IgM antibodies against hepatitis A virus (HAV), HAV infections can be regarded as autoimmune hepatitis when they show positive autoantibodies by indirect immunofluorescence and lack other viral markers. The aim of this study was to evaluate the prevalence, titres and impact of autoantibodies in Korean patients with HAV infection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>The study involved a retrospective review of the electronic medical records of 73 patients with HAV at Konkuk University Hospital from August 2005 to September 2008. The presence and pattern of anti-nuclear antibody, anti-smooth muscle antibody, anti-mitochondrial antibody and anti-liver\/kidney microsomal antibody were assessed by indirect immunofluorescence on Hep-2 cells and mouse\/kidney sections.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Of the 73 patients with hepatitis A, 65 (89.0%) showed positive indirect immunofluorescence tests. Of note, most of the positive tests (95.5%) showed a cytoplasmic pattern with filamentous staining of cytoplasmic fibres. There was no significant difference between groups in age or sex. In patients positive for autoantibodies, alanine aminotransferase and leucocyte count were significantly higher, while the increase in globulin was not statistically significant. In terms of titres, globulin was significantly higher in patients with \u2a7e1:160 titres than in those with \u2a7d1:80 titres (mean (SD) 3.4 (0.5) versus 2.8 (0.4) g\/dl, respectively; p\u200a=\u200a0.000).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>The study demonstrated a high prevalence of anticytoplasmic autoantibodies in patients with acute hepatitis A. These data would be useful to aid interpretation of indirect immunofluorescence testing in patients with acute hepatitis, especially in areas with a high prevalence of HAV.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jcp.2009.064410","type":"journal-article","created":{"date-parts":[[2009,5,22]],"date-time":"2009-05-22T20:16:17Z","timestamp":1243023377000},"page":"786-788","source":"Crossref","is-referenced-by-count":13,"title":["High prevalence of autoantibodies in hepatitis A infection: the impact on laboratory profiles"],"prefix":"10.1136","volume":"62","author":[{"given":"H W","family":"Moon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J K","family":"Noh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Hur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y M","family":"Yun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C H","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S Y","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2009,5,21]]},"reference":[{"key":"2025092506272050000_62.9.786.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(99)00467-3"},{"key":"2025092506272050000_62.9.786.2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1159\/000127428","article-title":"Hepatitis A in Korea: epidemiological shift and call for vaccine strategy.","volume":"51","author":"Lee","year":"2008","journal-title":"Intervirology"},{"key":"2025092506272050000_62.9.786.3","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2007.22.2.218"},{"key":"2025092506272050000_62.9.786.4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3349\/ymj.2000.41.1.34","article-title":"The changing epidemiology of hepatitis A in children and the consideration of active immunization in Korea.","volume":"41","author":"Sohn","year":"2000","journal-title":"Yonsei Med J"},{"key":"2025092506272050000_62.9.786.5","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2006.046276"},{"key":"2025092506272050000_62.9.786.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2004.00530.x"},{"key":"2025092506272050000_62.9.786.7","doi-asserted-by":"publisher","DOI":"10.1086\/427285"},{"key":"2025092506272050000_62.9.786.8","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200111000-00012"},{"key":"2025092506272050000_62.9.786.9","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260305"},{"key":"2025092506272050000_62.9.786.10","doi-asserted-by":"publisher","DOI":"10.1016\/0270-9139(95)90507-3"},{"key":"2025092506272050000_62.9.786.11","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1136\/gut.45.3.435","article-title":"Prevalence of non-organ-specific autoantibodies and chronic liver disease in the general population: a nested case\u00e2\u0080\u0093control study of the Dionysos cohort.","volume":"45","author":"Lenzi","year":"1999","journal-title":"Gut"},{"key":"2025092506272050000_62.9.786.12","doi-asserted-by":"publisher","DOI":"10.1186\/1740-2557-4-2"},{"key":"2025092506272050000_62.9.786.13","unstructured":"del Pozo D Cano A Pena E . [Autoimmune hepatitis with prolonged IGM antibodies to HAV. Are serological markers reliable in ruling out a diagnosis of autoimmune hepatitis?] Gastroenterol Hepatol 2001;24:387\u00e2\u0080\u00939."},{"key":"2025092506272050000_62.9.786.14","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(95)80336-X"},{"key":"2025092506272050000_62.9.786.15","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.3748\/wjg.v11.i24.3791","article-title":"Prolonged acute hepatitis A mimicking autoimmune hepatitis.","volume":"11","author":"Mikata","year":"2005","journal-title":"World J Gastroenterol"},{"key":"2025092506272050000_62.9.786.16","first-page":"106","article-title":"Idiopathic autoimmune chronic hepatitis triggered by hepatitis A.","volume":"89","author":"Rahaman","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"2025092506272050000_62.9.786.17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1665-2681(19)31878-2","article-title":"Autoimmune hepatitis induced by the prolonged hepatitis a virus infection.","volume":"7","author":"Tabak","year":"2008","journal-title":"Ann Hepatol"},{"key":"2025092506272050000_62.9.786.18","unstructured":"Tagle Arrospide M Leon Barua R . [Viral hepatitis A as a triggering agent of autoimmune hepatitis report of a case and review of literature.] Rev Gastroenterol Peru 2003;23:134\u00e2\u0080\u00937."},{"key":"2025092506272050000_62.9.786.19","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92858-Y"},{"key":"2025092506272050000_62.9.786.20","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840180435"},{"key":"2025092506272050000_62.9.786.21","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.20274"},{"key":"2025092506272050000_62.9.786.22","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.10040"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2009.064410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:27:28Z","timestamp":1758806848000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2009.064410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,21]]},"references-count":22,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2009,9,4]]},"published-print":{"date-parts":[[2009,9]]}},"alternative-id":["10.1136\/jcp.2009.064410"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2009.064410","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[2009,5,21]]}}}