{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:02:13Z","timestamp":1771326133520,"version":"3.50.1"},"reference-count":7,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2009,5,28]]},"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:sec>\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>Haemoglobinopathies are a group of inherited disorders of haemoglobin synthesis. Their frequency varies considerably with geographic location and ethnic group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aims:<\/jats:title>\n                  <jats:p>To establish the prevalence of haemoglobinopathies in a mainly healthy Iranian population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>All files of the haematology unit of the Boghrat laboratory over a period of 10 years (1998\u20132007) were analysed in relation to the age, sex, full blood count, haemoglobin electrophoresis results, high performance liquid chromatography (HPLC) findings, and iron profile of healthy subjects referred for consultation before marriage. Other tests were performed if indicated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>There were 34\u2009030 files; 13\u2009432 (39.5%) were for men, and 20\u2009567 (60.4%) for women. 0.74% of subjects (255) showed a haemoglobinopathy. The distribution of variant haemoglobins in these 255 subjects was: Hb D 75.67% (193 cases), Hb S 4.7%, Hb E 3.13%, Hb O-Arab 1.96% and Hb Lepore 0.39%. A fast haemoglobin was found in 4.71% of subjects. Of the subjects tested, 13.2% (4478) had \u03b2-thalassaemia minor, 0.2% (52) \u03b2-thalassaemia intermedia and 0.1% (30) \u03b2-thalassaemia major.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>In comparison with other parts of world, there is a different pattern of haemoglobinopathy with a high prevalence of Hb D, which appears to be Hb D Iran.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jcp.2009.064568","type":"journal-article","created":{"date-parts":[[2009,9,25]],"date-time":"2009-09-25T15:37:06Z","timestamp":1253893026000},"page":"924-925","source":"Crossref","is-referenced-by-count":11,"title":["Prevalence of haemoglobinopathies in 34\u2009030 healthy adults in Tehran, Iran"],"prefix":"10.1136","volume":"62","author":[{"given":"M T H","family":"Ashtiani","sequence":"first","affiliation":[{"name":"Pathology Department, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Monajemzadeh","sequence":"additional","affiliation":[{"name":"Pathology Department, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A H","family":"Sina","sequence":"additional","affiliation":[{"name":"Pathology Department, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Berenji","sequence":"additional","affiliation":[{"name":"Pathology Department, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Abdollahi","sequence":"additional","affiliation":[{"name":"Pathology Department, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M G","family":"Said","sequence":"additional","affiliation":[{"name":"Pathology Department, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Alam","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2009,9,25]]},"reference":[{"key":"2025092505565649000_62.10.924.1","unstructured":"Elghetany TM Banki K . Erythrocytic disorders. In: McPherson RA Pincus MR , eds. Henry\u2019s clinical diagnosis and management by laboratory methods, Vol. 31, 21st edn. Philadelphia: Saunders, 2006:522."},{"issue":"(8 Pt\u20092)","key":"2025092505565649000_62.10.924.2","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1093\/clinchem\/46.8.1284","article-title":"Laboratory investigation of hemoglobinopathies and thalassemias: review and update.","volume":"46","author":"Clarke","year":"2000","journal-title":"Clin Chem"},{"key":"2025092505565649000_62.10.924.3","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-007-0117-8"},{"key":"2025092505565649000_62.10.924.4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.329.7475.1134"},{"issue":"(Suppl 1)","key":"2025092505565649000_62.10.924.5","first-page":"i1","article-title":"Genetic blood disorders survey in the Sultanate of Oman.","volume":"49","author":"Al-Riyami","year":"2003","journal-title":"J Trop Pediatr"},{"key":"2025092505565649000_62.10.924.6","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5144\/0256-4947.2006.14","article-title":"Prevalence of beta-thalassemia trait in premarital screening in Al-Hassa, Saudi Arabia.","volume":"26","author":"Al-Suliman","year":"2006","journal-title":"Ann Saudi Med"},{"key":"2025092505565649000_62.10.924.7","first-page":"20","article-title":"Distribution of hemoglobinopathies and thalassemias in Qatari nationals seen at Hamad Hospital in Qatar.","volume":"12","author":"Fawzi","year":"2003","journal-title":"Qatar Med J"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2009.064568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:57:03Z","timestamp":1758805023000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2009.064568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,25]]},"references-count":7,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2009,9,25]]},"published-print":{"date-parts":[[2009,10]]}},"alternative-id":["10.1136\/jcp.2009.064568"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2009.064568","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,25]]}}}