{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:41:49Z","timestamp":1790894509358,"version":"4.1.0"},"reference-count":37,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>Pleomorphic adenomas of the salivary gland have gender and age distributions suggesting that oestrogen has a causal role. However, oestrogen receptor (ER)\u03b1 is expressed at low levels in normal salivary gland tissues and data from salivary gland tumours are conflicting. There is preliminary evidence that the recently described ER\u03b2 may be the major ER in salivary gland tissue. The aim of this study was to determine the nature and extent of ER\u03b2 expression in pleomorphic adenomas of the salivary gland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Pleomorphic adenomas and normal tissues of the parotid gland from 49 patients were tested for ER\u03b1 and ER\u03b2 expression by semiquantitative immunohistochemistry. Associations were sought with patient age and gender.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>ER\u03b1 and ER\u03b2 expression was localised mainly to the nuclei of ductal cells in normal tissues and the epithelial components in pleomorphic adenomas. Within each tissue and receptor type there were no associations between ER positivity and patient age or gender. ER\u03b2 was expressed in almost twice as many normal tissues and pleomorphic adenomas as ER\u03b1. Expression of ER\u03b2 was also significantly higher in tumour compared with normal tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This is thought to be the first study of ER\u03b2 in pleomorphic adenomas of the salivary gland. Findings support ER\u03b2 as the major ER in salivary glands, and provide evidence that ER\u03b2 may have a role in the development of pleomorphic adenomas of the salivary gland.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jcp.2009.065102","type":"journal-article","created":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T15:32:48Z","timestamp":1252078368000},"page":"789-793","source":"Crossref","is-referenced-by-count":13,"title":["Oestrogen receptor \u03b2 expression in pleomorphic adenomas of the parotid gland"],"prefix":"10.1136","volume":"62","author":[{"given":"M H W","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T A","family":"Dobbins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Tseung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C S","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C J","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B R","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2009,9,4]]},"reference":[{"key":"2025120520161123000_62.9.789.1","unstructured":"Barnes L , Eveson, JW, Reichart P, Sidransky D, eds. 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