{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:55:54Z","timestamp":1791190554458,"version":"4.1.0"},"reference-count":24,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2009,5,27]]},"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:sec>\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>Papillary renal cell tumours (RCTs) have been described as a genetic entity. Recently, papillary RCTs have been divided into small (type 1) and large (type 2) cell tumours. Subsequent DNA analyses have resulted in controversial data regarding putative genetic changes marking type 1 and type 2 tumours.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim:<\/jats:title>\n                  <jats:p>The aim of this study was to improve the original description that papillary RCT is a genetic entity regardless of the phenotypic variation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>DNA from 163 papillary RCTs, including 82 multiplex tumours from eight hereditary cases, was analysed for copy number changes by chromosomal comparative genomic hybridisation (CGH) and\/or for allelic changes at chromosomes 7 and 17 by microsatellite analysis. The results of the genetic analysis were compared with the cytological characteristics of the tumours.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>The results showed alterations of chromosomes 7 and 17 at similar frequencies in papillary RCTs with characteristics ranging from small to large cell, nuclear grade 1 to 3, and 3 mm to 16 cm diameter.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>Trisomies of chromosomes 7 and 17 are specific genetic alterations in papillary RCTs irrespective of their size, grade and cellular differentiation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jcp.2009.066423","type":"journal-article","created":{"date-parts":[[2009,6,18]],"date-time":"2009-06-18T20:27:02Z","timestamp":1245356822000},"page":"892-895","source":"Crossref","is-referenced-by-count":26,"title":["Trisomy 7 and 17 mark papillary renal cell tumours irrespectively of variation of the phenotype"],"prefix":"10.1136","volume":"62","author":[{"given":"I","family":"Balint","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Oncology, Medical Faculty, Ruprecht-Karls-University, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Szponar","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Medical Faculty, Ruprecht-Karls-University, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Jauch","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Medical Faculty, Ruprecht-Karls-University, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Medical Faculty, Ruprecht-Karls-University, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2009,6,18]]},"reference":[{"key":"2025092509183500000_62.10.892.1","first-page":"27","article-title":"Papillary renal carcinoma: a morphologic and cytogenetic study of 11 cases.","volume":"134","author":"Kovacs","year":"1989","journal-title":"Am J Pathol"},{"key":"2025092509183500000_62.10.892.2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870030403"},{"key":"2025092509183500000_62.10.892.3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199710)183:2<131::AID-PATH931>3.0.CO;2-G"},{"key":"2025092509183500000_62.10.892.4","first-page":"537","article-title":"Papillary renal cell carcinoma: a clinicopathologic and immunohistochemical study of 105 tumors.","volume":"10","author":"Delahunt","year":"1997","journal-title":"Mod Pathol"},{"key":"2025092509183500000_62.10.892.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65734-3"},{"key":"2025092509183500000_62.10.892.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64260-5"},{"key":"2025092509183500000_62.10.892.7","unstructured":"Eble JN Sauter G Epstein JI . World Health Organization classification of tumours. Pathology and genetics of tumours of the urinary system and male genital organs. Lyon: IARC Press, 2004."},{"key":"2025092509183500000_62.10.892.8","first-page":"301","article-title":"Parenchymal abnormalities associated with papillary renal cell tumors.","volume":"1","author":"Kovacs","year":"1993","journal-title":"J Urol Pathol"},{"key":"2025092509183500000_62.10.892.9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0065-230X(08)60316-4","article-title":"Molecular cytogenetics of renal cell tumors.","volume":"62","author":"Kovacs","year":"1993","journal-title":"Adv Cancer Res"},{"key":"2025092509183500000_62.10.892.10","unstructured":"Lichter P Cremer T . Chromosome analysis by non-isotopic in situ hybridization. In: Rooney DE Czepulkowski BH , eds. Human Cytogenetics \u2013 a practical approach. 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