{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T03:33:39Z","timestamp":1758944019541,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:sec>\n                  <jats:title>Aim:<\/jats:title>\n                  <jats:p>To determine the clinicopathological properties of ocular adnexal marginal zone B cell lymphomas (MZBLs) with CD5+ B cells.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>This study determined the clinicopathological properties of MZBL samples from 97 patients with ocular adnexal MZBLs and searched for hallmarks of systemic autoimmunity in these patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Two elderly female patients were found to have ocular adnexal MZBLs with CD5+ B cells; flow cytometry analysis suggested that one of these MZBLs had CD5+ B cell clonal proliferation. The levels of anti-single stranded (SS)-DNA and anti-SS-A\/Ro antibodies in these two patients were significantly higher than those in controls that were matched for age, gender and disease (2\/2 versus 0\/14; p\u200a=\u200a0.008) and controls without MZBL (2\/2 versus 0\/30; p\u200a=\u200a0.002). The genes from the immunoglobulin heavy-chain variable region for one of the patients showed a V3-21 segment. In addition, another patient with ocular adnexal reactive lymphoid hyperplasia with CD5+ B cells also had anti-SS-DNA antibodies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>Patients with ocular adnexal MZBLs with CD5+ B cells may have a background of systemic conditions with CD5+ B-cell-related autoantibodies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jcp.2009.067603","type":"journal-article","created":{"date-parts":[[2009,12,21]],"date-time":"2009-12-21T14:00:35Z","timestamp":1261404035000},"page":"79-82","source":"Crossref","is-referenced-by-count":5,"title":["Correlation of autoantibodies and CD5+ B cells in ocular adnexal marginal zone B cell lymphomas"],"prefix":"10.1136","volume":"63","author":[{"given":"T","family":"Kubota","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Moritani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Terasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2009,12,21]]},"reference":[{"key":"2025092504502700000_63.1.79.1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213350.49767.46"},{"key":"2025092504502700000_63.1.79.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)98024-1"},{"key":"2025092504502700000_63.1.79.3","unstructured":"Swerdlow SH Campo E Harris NL . 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