{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:48:26Z","timestamp":1779371306051,"version":"3.53.1"},"reference-count":9,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:p>\n                    Carcinosarcoma of the pancreas is extremely rare and its histogenesis is still unclear. This is a report on a 64-year-old female patient with an intraductal carcinosarcoma arising from intraductal papillary-mucinous carcinoma (IPMC) in the pancreas tail. The carcinosarcoma grew as a polypoid mass within the main pancreatic duct. Histologically, the tumour consisted of adenocarcinoma covering the luminal surface of the lesion with minimal stromal invasion, and osteosarcoma occupying the stroma. Immunohistochemical and gene mutation analyses revealed that both the carcinomatous and sarcomatous tumour cells of the carcinosarcoma, as well as the IPMC cells, expressed TP53 and had identical mutations in\n                    <jats:italic>KRAS<\/jats:italic>\n                    and\n                    <jats:italic>TP53<\/jats:italic>\n                    genes, indicating that these two neoplastic components of the carcinosarcoma shared a common tumorigenesis and arose from the IPMC. This is the first report of a carcinosarcoma originating in IPMC. These findings imply that carcinosarcoma with a heterologous mesenchymal component is of ductal origin.\n                  <\/jats:p>","DOI":"10.1136\/jcp.2009.071613","type":"journal-article","created":{"date-parts":[[2010,3,4]],"date-time":"2010-03-04T11:19:48Z","timestamp":1267701588000},"page":"266-269","source":"Crossref","is-referenced-by-count":14,"title":["Intraductal carcinosarcoma with a heterologous mesenchymal component originating in intraductal papillary-mucinous carcinoma (IPMC) of the pancreas with both carcinoma and osteosarcoma cells arising from IPMC cells"],"prefix":"10.1136","volume":"63","author":[{"given":"Jun","family":"Okamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Sekine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Nara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Ojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yae","family":"Kanai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyoshi","family":"Hiraoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2010,3,4]]},"reference":[{"key":"2025120600435154000_63.3.266.1","first-page":"132","article-title":"Malignant mixed tumor (carcinosarcoma) of the pancreas: A case report supporting organ-induced differentiation of malignancy","volume":"115","author":"Millis","year":"1994","journal-title":"Surgery"},{"key":"2025120600435154000_63.3.266.2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199701000-00008"},{"key":"2025120600435154000_63.3.266.3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/00006676-199708000-00013","article-title":"Mixed osteoclastic\/pleomorphic-type giant cell tumor of the pancreas with ductal adenocarcinoma: Histochemical and immunohistochemical study with review of the literature","volume":"15","author":"Watanabe","year":"1997","journal-title":"Pancreas"},{"key":"2025120600435154000_63.3.266.4","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.5858\/2002-126-1114-COTP","article-title":"Carcinosarcoma of the pancreas: A case report and review of the literature","volume":"126","author":"Darvishian","year":"2002","journal-title":"Arch Pathol Lab Med"},{"key":"2025120600435154000_63.3.266.5","first-page":"343","article-title":"A unique pancreatic ductal adenocarcinoma with carcinosarcomatous histology, immunohistochemical distribution of hCG-beta, and the elevation of serum alpha-feto-protein","volume":"35","author":"Yamazaki","year":"2003","journal-title":"J Submicrosc Cytol Pathol"},{"key":"2025120600435154000_63.3.266.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2008.02289.x"},{"key":"2025120600435154000_63.3.266.7","unstructured":"Hruban RH Pitman MB Klimstra DS . eds. AFIP Atlas of the Tumor Pathology Fourth Series Fascicle 6: Tumors of the Pancreas. Washington, DC: American Registry of Pathology, 2007."},{"key":"2025120600435154000_63.3.266.8","unstructured":"Hamilton SR Aaltonen LA , eds. Pathology and genetics. Tumours of the digestive system. World Health Organization Classification of Tumours. Lyon, France: IARC Press, 2000."},{"key":"2025120600435154000_63.3.266.9","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/jcp.55.5.321","article-title":"Malignant biphasic uterine tumors: carcinosarcomas or metaplastic carcinomas?","volume":"55","author":"McCluggage","year":"2002","journal-title":"J Clin Pathol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2009.071613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:43:58Z","timestamp":1765010638000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2009.071613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,3,4]]},"published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1136\/jcp.2009.071613"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2009.071613","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}