{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:04:54Z","timestamp":1791266694478,"version":"4.1.0"},"reference-count":19,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The authors have previously reported genomic subtypes of chronic fatigue syndrome\/myalgic encephalomyelitis (CFS\/ME) based on expression of 88 human genes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To attempt to reproduce these findings, determine the specificity of this signature to CFS\/ME, and test for associations between CFS\/ME subtype and infection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Expression levels of 88 human genes were determined in blood of 62 new patients with idiopathic CFS\/ME (according to Fukuda criteria), six patients with Q-fever-associated CFS\/ME from the Birmingham Q-fever outbreak (according to Fukuda criteria), 14 patients with endogenous depression (according to DSM-IV criteria) and 29 normal blood donors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In patients with CFS\/ME, differential expression was confirmed for all 88 genes. Q-CFS\/ME had similar patterns of gene expression to idiopathic CFS\/ME. Gene expression in patients with endogenous depression was similar to that in the normal controls, except for upregulation of five genes (<jats:italic>APP<\/jats:italic>, <jats:italic>CREBBP<\/jats:italic>, <jats:italic>GNAS<\/jats:italic>, <jats:italic>PDCD2<\/jats:italic> and <jats:italic>PDCD6<\/jats:italic>).<\/jats:p>\n                  <jats:p>Clustering of combined gene data in CFS\/ME patients for this and the authors' previous study (117 CFS\/ME patients) revealed genomic subtypes with distinct differences in SF36 scores, clinical phenotypes, severity and geographical distribution. Antibody testing for Epstein\u2013Barr virus, enterovirus, <jats:italic>Coxiella burnetii<\/jats:italic> and parvovirus B19 revealed evidence of subtype-specific relationships for Epstein\u2013Barr virus and enterovirus, the two most common infectious triggers of CFS\/ME.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study confirms the involvement of these genes in CFS\/ME.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jcp.2009.072561","type":"journal-article","created":{"date-parts":[[2009,12,2]],"date-time":"2009-12-02T23:07:38Z","timestamp":1259795258000},"page":"156-164","source":"Crossref","is-referenced-by-count":68,"title":["Microbial infections in eight genomic subtypes of chronic fatigue syndrome\/myalgic encephalomyelitis"],"prefix":"10.1136","volume":"63","author":[{"given":"Lihan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Gough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Christmas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek L","family":"Mattey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selwyn C M","family":"Richards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Main","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Enlander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Honeybourne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon G","family":"Ayres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Nutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R","family":"Kerr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2009,12,2]]},"reference":[{"key":"2025092505512117000_63.2.156.1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-12-199412150-00009"},{"key":"2025092505512117000_63.2.156.2","unstructured":"A report of the CFS\/ME Working Group. Department of Health January 2002. http:\/\/www.dh.gov.uk."},{"key":"2025092505512117000_63.2.156.3","doi-asserted-by":"publisher","DOI":"10.1159\/000075315"},{"key":"2025092505512117000_63.2.156.4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.49.1.1"},{"key":"2025092505512117000_63.2.156.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2006.08.013"},{"key":"2025092505512117000_63.2.156.6","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.025718"},{"key":"2025092505512117000_63.2.156.7","doi-asserted-by":"publisher","DOI":"10.1086\/533453"},{"key":"2025092505512117000_63.2.156.8","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2007.053553"},{"key":"2025092505512117000_63.2.156.9","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-3-25"},{"key":"2025092505512117000_63.2.156.10","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(93)90081-P"},{"key":"2025092505512117000_63.2.156.11","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/18.1.207"},{"key":"2025092505512117000_63.2.156.12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.25.14863"},{"key":"2025092505512117000_63.2.156.13","first-page":"595","article-title":"Chronic fatigue syndrome (CFS) and arthralgia following parvovirus B19 infection","volume":"29","author":"Kerr","year":"2002","journal-title":"J Rheumatol"},{"key":"2025092505512117000_63.2.156.14","doi-asserted-by":"publisher","DOI":"10.1086\/374666"},{"key":"2025092505512117000_63.2.156.15","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2007.051342"},{"key":"2025092505512117000_63.2.156.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92722-5"},{"key":"2025092505512117000_63.2.156.17","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2007.050054"},{"key":"2025092505512117000_63.2.156.18","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-005-3588-2"},{"key":"2025092505512117000_63.2.156.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2006.01.003"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2009.072561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:51:27Z","timestamp":1758804687000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2009.072561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,2]]},"references-count":19,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,2,12]]},"published-print":{"date-parts":[[2010,2]]}},"alternative-id":["10.1136\/jcp.2009.072561"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2009.072561","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,2]]}}}