{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:49:27Z","timestamp":1791301767187,"version":"4.1.0"},"reference-count":17,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2010,3,11]]},"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>Sessile serrated adenomas (SSAs) are recognised as precursors to microsatellite unstable adenocarcinomas. This study attempts to estimate the progression rate of SSAs based upon the epidemiology of a large cohort as well as identify relationships to other colorectal polyps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pathological reports generated at Caris Diagnostics from 290\u2009810 colonoscopic specimens on 179\u2009111 patients were analysed using computerised algorithms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SSAs with or without dysplasia\/carcinoma (SSA+\/\u2013) were identified in 2416 specimens from 2139 patients (54% women). The distribution of SSA+\/\u2013 was: right-sided (81.2%); left-sided (11.2%); both right- and left-sided (3.2%); not specified (4.3%). There were 1816 (85%) patients without dysplasia (SSA\u2013), 257 (12%) with low-grade dysplasia (SSA-LD), 45 (2%) with high-grade dysplasia (SSA-HD) and 21 (1%) with adenocarcinoma (SSA-CA). The difference in median age between almost all groups was significant (SSA\u2013=61\u2005years versus SSA-LD=66\u2005years (p&lt;0.001) vs SSA-HD=72\u2005years (p=0.002) vs SSA-CA=76\u2005years (p=0.07, NS)). Women comprised 53% of the SSA\u2013 group (968\/1816), 57% of the SSA-LD group (147\/257), 69% of the SSA-HD group (31\/45) and 76% of the SSA-CA group (16\/21), being more likely to have high-grade dysplasia (OR 1.94, 95% CI 1.03 to 3.67) and adenocarcinoma (OR 2.80, 95% CI 1.02 to 7.68).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>1.7% of patients with mucosal polyps had SSAs (with and without dysplasia), more commonly in women and primarily in the right colon. Dysplasia or carcinoma was identified in 15% of patients and significantly disproportionately among women. Based on significant age differences between groups, there appears to be a stepwise progression of dysplasia and carcinoma in SSAs over 10 to 15\u2005years, a period two to three times longer than that for conventional adenomas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jcp.2010.075507","type":"journal-article","created":{"date-parts":[[2010,6,14]],"date-time":"2010-06-14T23:39:56Z","timestamp":1276558796000},"page":"681-686","source":"Crossref","is-referenced-by-count":269,"title":["Sessile serrated adenomas: prevalence of dysplasia and carcinoma in 2139 patients"],"prefix":"10.1136","volume":"63","author":[{"given":"Richard H","family":"Lash","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M","family":"Genta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M","family":"Schuler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2010,6,14]]},"reference":[{"key":"2025112108161059000_63.8.681.1","doi-asserted-by":"publisher","DOI":"10.1309\/V2EPTPLJRB3FGHJL"},{"key":"2025112108161059000_63.8.681.2","doi-asserted-by":"publisher","DOI":"10.1309\/V8Q9KDD5AJ9LNBAG"},{"key":"2025112108161059000_63.8.681.3","doi-asserted-by":"publisher","DOI":"10.1309\/C7JE8BVL8420V5VT"},{"key":"2025112108161059000_63.8.681.4","doi-asserted-by":"publisher","DOI":"10.1309\/DRFQ0WFUF1G13CTK"},{"key":"2025112108161059000_63.8.681.5","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(200103)193:3<283::AID-PATH799>3.0.CO;2-9"},{"key":"2025112108161059000_63.8.681.6","doi-asserted-by":"publisher","DOI":"10.1309\/8H7MUH9ET9U21R2E"},{"key":"2025112108161059000_63.8.681.7","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093587"},{"key":"2025112108161059000_63.8.681.8","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8608884"},{"key":"2025112108161059000_63.8.681.9","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.23510"},{"key":"2025112108161059000_63.8.681.10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01301.x"},{"key":"2025112108161059000_63.8.681.11","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1997.03890440019002"},{"key":"2025112108161059000_63.8.681.12","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199006000-00003"},{"key":"2025112108161059000_63.8.681.13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02180.x"},{"key":"2025112108161059000_63.8.681.14","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200301000-00008"},{"key":"2025112108161059000_63.8.681.15","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-200405000-00002"},{"key":"2025112108161059000_63.8.681.16","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0407-7"},{"key":"2025112108161059000_63.8.681.17","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.3461"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2010.075507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:16:17Z","timestamp":1763741777000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2010.075507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,14]]},"references-count":17,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2010,8,11]]},"published-print":{"date-parts":[[2010,8]]}},"alternative-id":["10.1136\/jcp.2010.075507"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2010.075507","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,14]]}}}