{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T17:09:27Z","timestamp":1776272967373,"version":"3.50.1"},"reference-count":24,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2010,5,5]]},"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine the cellular location and expression of MUC17 mucin in specimens of normal, inflamed and neoplastic colon.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Immunohistochemical analysis of human surgical resection specimens (n=106) was performed with a specific antibody to the MUC17 apomucin protein. A semi-quantitative scoring system was used to measure MUC17 expression. In various colon cancer cell lines, the MUC17 expression was examined by immunoblot analysis and normal RT-PCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MUC17 was highly expressed on the surface epithelium and crypts of colonic mucosa. In contrast, the expression of MUC17 was significantly decreased in colonic mucosa of chronic ulcerative colitis (p&lt;0.0001) and ischaemic colitis (p=0.003). Similarly, MUC17 expression was decreased in hyperplastic polyps (p=0.0003), tubular and tubulovillous adenomas (p&lt;0.0001) and colon cancers (p&lt;0.0001). Furthermore, of eight different colon cancer cell lines, MUC17 expression was only detected in LS174T and LS180 cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Results indicate that the potential protective effects of this membrane-bound mucin are primarily or secondarily diminished in inflammatory and neoplastic conditions. Further research is needed to determine the specific role of MUC17 in the pathogenesis of these conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jcp.2010.078717","type":"journal-article","created":{"date-parts":[[2010,8,11]],"date-time":"2010-08-11T05:17:50Z","timestamp":1281503870000},"page":"702-707","source":"Crossref","is-referenced-by-count":45,"title":["Expression of intestinal MUC17 membrane-bound mucin in inflammatory and neoplastic diseases of the colon"],"prefix":"10.1136","volume":"63","author":[{"given":"Shantibhusan","family":"Senapati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel B","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poonam","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srustidhar","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhankar","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukhwinder","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Niehans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surinder K","family":"Batra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2010,8,11]]},"reference":[{"key":"2025120523223770000_63.8.702.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(01)02052-7"},{"key":"2025120523223770000_63.8.702.2","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.1016\/S0021-9258(18)83373-7","article-title":"Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism","volume":"264","author":"Gum","year":"1989","journal-title":"J Biol Chem"},{"key":"2025120523223770000_63.8.702.3","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(90)91408-K"},{"key":"2025120523223770000_63.8.702.4","doi-asserted-by":"crossref","first-page":"15294","DOI":"10.1016\/S0021-9258(18)77255-4","article-title":"Cloning and sequencing of a human pancreatic tumor mucin cDNA","volume":"265","author":"Lan","year":"1990","journal-title":"J Biol Chem"},{"key":"2025120523223770000_63.8.702.5","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1164\/ajrccm\/144.3_pt_2.S15","article-title":"Structural features of the core proteins of human airway mucins ascertained by cDNA cloning","volume":"144","author":"Porchet","year":"1991","journal-title":"Am Rev Respir Dis"},{"key":"2025120523223770000_63.8.702.6","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1251"},{"key":"2025120523223770000_63.8.702.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2009.10.003"},{"key":"2025120523223770000_63.8.702.8","doi-asserted-by":"crossref","first-page":"5733","DOI":"10.4049\/jimmunol.161.10.5733","article-title":"A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis","volume":"161","author":"Panwala","year":"1998","journal-title":"J Immunol"},{"key":"2025120523223770000_63.8.702.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020831"},{"key":"2025120523223770000_63.8.702.10","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1042\/cs0830623","article-title":"Sulphation of colonic and rectal mucin in inflammatory bowel disease: reduced sulphation of rectal mucus in ulcerative colitis","volume":"83","author":"Raouf","year":"1992","journal-title":"Clin Sci (Lond)"},{"key":"2025120523223770000_63.8.702.11","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.1039"},{"key":"2025120523223770000_63.8.702.12","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.04.020"},{"key":"2025120523223770000_63.8.702.13","doi-asserted-by":"publisher","DOI":"10.1038\/ng1096-199"},{"key":"2025120523223770000_63.8.702.14","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.5.572"},{"key":"2025120523223770000_63.8.702.15","doi-asserted-by":"publisher","DOI":"10.1007\/s100380170118"},{"key":"2025120523223770000_63.8.702.16","doi-asserted-by":"publisher","DOI":"10.1177\/002215549904700808"},{"key":"2025120523223770000_63.8.702.17","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2002.6475"},{"key":"2025120523223770000_63.8.702.18","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600302200"},{"key":"2025120523223770000_63.8.702.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2010.03.001"},{"key":"2025120523223770000_63.8.702.20","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.09.006"},{"key":"2025120523223770000_63.8.702.21","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20372"},{"key":"2025120523223770000_63.8.702.22","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604329"},{"key":"2025120523223770000_63.8.702.23","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-006-0100-2"},{"key":"2025120523223770000_63.8.702.24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M206883200"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2010.078717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:22:44Z","timestamp":1765005764000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2010.078717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":24,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2010,8,11]]},"published-print":{"date-parts":[[2010,8]]}},"alternative-id":["10.1136\/jcp.2010.078717"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2010.078717","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}