{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:41:43Z","timestamp":1788406903068,"version":"build-2803163510"},"reference-count":41,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2010,7,16]]},"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The assessment of malignant potential of oral submucous fibrosis grades vis-\u00e0-vis their progression towards malignancy is associated with expression of possible multiple molecular markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To analyse p63, E-cadherin and CD105 expression in this premalignant pathosis with a view to unravel and understand the expression of these molecules as markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The oral mucosal biopsies (normal, oral submucous fibrosis with and without dysplasia) were studied with routine H&amp;E, and by immunohistochemistry for p63, E-cadherin and CD105 expression. p63 was assessed as percentage of positive nuclei. E-cadherin expression was estimated through (i) distance between basement membrane and E-cadherin expression initiation point, (ii) ratio between epithelial thickness and epithelial thickness displaying E-cadherin, and (iii) E-cadherin intensity variation along the expression path. CD105 expression was assessed qualitatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The p63+ cells were highest in severely dysplastic tissues followed by other dysplastic grades, normal oral mucosa and non-dysplastic conditions. However, the p63+ cells displayed the feature of progressive maturation only in normal mucosa. There was a loss of membranous E-cadherin in basal layers of all diseased conditions; it was highest in severe dysplasia. There was significant variation (p&lt;0.0001) in E-cadherin intensity within and between the tissues (normal and diseased). CD105 expression increased abruptly in dysplasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The malignant potential of this pre-cancerous condition is likely to be correlated with an increase in p63 and CD105 expression and a concomitant loss of membranous E-cadherin. This may lead to marker identification through greater validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jcp.2010.078964","type":"journal-article","created":{"date-parts":[[2010,9,27]],"date-time":"2010-09-27T12:38:55Z","timestamp":1285591135000},"page":"894-899","source":"Crossref","is-referenced-by-count":41,"title":["Assessment of malignant potential of oral submucous fibrosis through evaluation of p63, E-cadherin and CD105 expression"],"prefix":"10.1136","volume":"63","author":[{"given":"Raunak Kumar","family":"Das","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mousumi","family":"Pal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananya","family":"Barui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjan Rashmi","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandan","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajoy Kumar","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghamitra","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotirmoy","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2010,9,27]]},"reference":[{"key":"2025121407024740000_63.10.894.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.12.008"},{"key":"2025121407024740000_63.10.894.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2008.04.003"},{"key":"2025121407024740000_63.10.894.3","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2008.2355"},{"key":"2025121407024740000_63.10.894.4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990315)80:6<827::AID-IJC6>3.0.CO;2-P"},{"key":"2025121407024740000_63.10.894.5","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.022095"},{"key":"2025121407024740000_63.10.894.6","first-page":"63","article-title":"Comparative epiemiology of oral cancer in Brazil & India","volume":"16","author":"Hamada","year":"1991","journal-title":"Tokai J Exp. 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