{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T03:15:17Z","timestamp":1774667717079,"version":"3.50.1"},"reference-count":15,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2010,8,9]]},"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To investigate the presence of IgG4+ plasma cells in gastric mucosal biopsy samples from patients with atrophic gastritis (AG) and a history of pernicious anaemia (PA) (AG+PA+).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Gastric mucosal biopsy specimens from 46 patients with AG+PA+ were investigated. As controls, we evaluated specimens from patients with AG but no history of PA (AG+ PA\u2013) (n=25), normal histology (n=25), mild chronic inactive gastritis (MCIG) (n=25) or <jats:italic>Helicobacter pylori<\/jats:italic> gastritis (HP) (n=25). IgG4+ plasma cells were detected by two immunohistochemical methods: (1) using a monoclonal antibody, the average of the three most cellular high-power fields was counted in areas with the highest density of IgG4+ plasma cells; (2) using a dual-chromagen stain for both IgG4 and CD138 (plasma cell marker), the number of IgG4+ cells per 200 CD138+ plasma cells was counted. The latter was used to ensure that the number of IgG4+ cells was not simply related to the degree of inflammation (density of plasma cells).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Identical results were obtained with the two staining methods. Increased numbers of IgG4+ plasma cells were present in 37% of patients with AG+PA+, but in none with AG+PA\u2013, MCIG, HP or normal gastric biopsy results (100% specific, p=0.0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>IgG4+ plasma cells may play a role in the pathogenesis of PA and may be a useful marker for its diagnosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jcp.2010.081232","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T23:10:13Z","timestamp":1286320213000},"page":"999-1001","source":"Crossref","is-referenced-by-count":18,"title":["Significant increase in IgG4+ plasma cells in gastric biopsy specimens from patients with pernicious anaemia"],"prefix":"10.1136","volume":"63","author":[{"given":"Ahmed S","family":"Bedeir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard H","family":"Lash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan G","family":"Lash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukunda B","family":"Ray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2010,10,5]]},"reference":[{"key":"2025092501283367000_63.11.999.1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.0954-6820.1969.tb07363.x","article-title":"Morbidity of pernicious anaemia. Incidence, prevalence, and treatment in a Danish county","volume":"185","author":"Pedersen","year":"1969","journal-title":"Acta Med Scand"},{"key":"2025092501283367000_63.11.999.2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1996.00040041097008"},{"key":"2025092501283367000_63.11.999.3","unstructured":"Wintrobe M Lee G Boggs D . Megaloblastic and nonmegaloblastic macrocytic anemias. In: Wintrobe MM Lee GR Boggs DR , eds. Clinical hematology. 8th edn. Philadelphia: Lea & Febiger, 1981:559\u2013604."},{"key":"2025092501283367000_63.11.999.4","unstructured":"Lee E Feldman M . Gastritis and other gastropathies. In: Feldman M Friedman LS Sleisenger MH , eds. Sleisenger & Fordtran's gastrointestinal and liver disease: pathophysiology, diagnosis, management. 7th edn. Philadelphia: Saunders, 2002: 810\u201327."},{"key":"2025092501283367000_63.11.999.5","first-page":"22","article-title":"The association between autoimmune thyroiditis, autoimmune gastritis and type 1 diabetes","volume":"1","author":"Lam-Tse","year":"2003","journal-title":"Pediatr Endocrinol Rev"},{"key":"2025092501283367000_63.11.999.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711133372007"},{"key":"2025092501283367000_63.11.999.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2007.03.015"},{"key":"2025092501283367000_63.11.999.8","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00006676-200408000-00014","article-title":"IgG4-positive plasma cells specifically infiltrate various organs in autoimmune pancreatitis","volume":"29","author":"Kamisawa","year":"2004","journal-title":"Pancreas"},{"key":"2025092501283367000_63.11.999.9","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1862-6"},{"key":"2025092501283367000_63.11.999.10","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800689"},{"key":"2025092501283367000_63.11.999.11","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.5121"},{"key":"2025092501283367000_63.11.999.12","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.1.1"},{"key":"2025092501283367000_63.11.999.13","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-009-0052-8"},{"key":"2025092501283367000_63.11.999.14","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1175-y"},{"key":"2025092501283367000_63.11.999.15","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.5.683"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.2010.081232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:28:45Z","timestamp":1758788925000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.2010.081232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,5]]},"references-count":15,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2010,10,23]]},"published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1136\/jcp.2010.081232"],"URL":"https:\/\/doi.org\/10.1136\/jcp.2010.081232","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,5]]}}}